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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vetpress</journal-id><journal-title-group><journal-title xml:lang="ru">Аграрная наука</journal-title><trans-title-group xml:lang="en"><trans-title>Agrarian science</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-8155</issn><issn pub-type="epub">2686-701X</issn><publisher><publisher-name>Редакция журнала "Аграрная наука"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.32634/0869-8155-2020-341-9-22-29</article-id><article-id custom-type="elpub" pub-id-type="custom">vetpress-1283</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВЕТЕРИНАРНАЯ ФАРМАКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>VETERINARY PHARMACOLOGY</subject></subj-group></article-categories><title-group><article-title>Альтернативный подход к схеме лечения некротического энтерита у цыплят-бройлеров без антибиотика-стимулятора роста</article-title><trans-title-group xml:lang="en"><trans-title>An alternative approach to the treatment regimen for necrotic enteritis in broiler chickens without antibiotics-growth stimulants</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дорофеева</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Dorofeeva</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заместитель генерального директора по ветеринарии, к.в.н.</p><p>Егорьевское ш., 3А, Красково, Московская обл., 140051</p></bio><bio xml:lang="en"><p>Deputy Director-General for veterinary medicine, Ph.D in veterinary medicine</p><p>Egoryevskoe highway, 3A, Kraskovo, Moscow region, 140051</p></bio><email xlink:type="simple">dorofeeva@tdvic.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полуночкина</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Polunochkina</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ведущий ветеринарный врач-консультант департамента «Птицеводство»</p><p>Егорьевское ш., 3А, Красково, Московская обл., 140051</p></bio><bio xml:lang="en"><p>learding veterinary consultant of department «Poultry»</p><p>Egoryevskoe highway, 3A, Kraskovo, Moscow region, 140051</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГК ВИК</institution><country>Россия</country></aff><aff xml:lang="en"><institution>VIC group</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>01</day><month>11</month><year>2020</year></pub-date><volume>0</volume><issue>9</issue><fpage>22</fpage><lpage>29</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дорофеева С.Г., Полуночкина Т.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Дорофеева С.Г., Полуночкина Т.В.</copyright-holder><copyright-holder xml:lang="en">Dorofeeva S.G., Polunochkina T.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vetpress.ru/jour/article/view/1283">https://www.vetpress.ru/jour/article/view/1283</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Работа посвящена актуальной проблеме желудочно-кишечных  заболеваний у птицы, так как при возможном запрете введения кормовых антибиотиков в  РФ в корм птице есть вероятность подъема заболеваемости кишечными заболеваниями и, в частности, — некротическим энтеритом, как это было в Европе при запрете на  антибиотики-стимуляторы роста. Целью наших исследований была разработка лечебно-профилактической схемы при некротическом энтерите у цыплят-бройлеров без антибиотика-стимулятора роста.</p></sec><sec><title>Методы</title><p>Методы. Производственный опыт проводили в РФ на одной из птицефабрик крупного холдинга на кроссе РОСС 308 при напольном содержании цыплят-бройлеров. Лабораторные исследования были проведены в Федеральном бюджетном учреждении науки Государственном научном центре прикладной микробиологии и биотехнологии (ФБУН ГНЦ ПМБ). На основании клинических, патолого-анатомических и лабораторных исследований по законченным партиям выращивания бройлеров был поставлен диагноз некротический энтерит и составлена схема лечебных мероприятий для следующих партий цыплят без применения антибиотика-стимулятора роста. В схему вошли  препараты Клиндаспектин®, Соламокс®, Авикер® T SL и Продактив® Ацид Sе.</p></sec><sec><title>Результаты</title><p>Результаты. Производственный опыт показал, что последовательное введение в схему лечения на период откорма цыплят-бройлеров препаратов Клиндаспектин®, Авикер® T  SL, Соламокс®, Продактив® Ацид Se позволило достичь наилучших производственных  показателей без применения антибиотика-стимулятора роста.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. The work is devoted to the urgent problem of gastrointestinal diseases in poultry, since with the prohibition of the introduction of feed antibiotics in the Russian Federation in poultry feed, an increase in the incidence of intestinal diseases and, in particular, necrotic enteritis is possible, as was the case in Europe with the ban on antibiotics-growth stimulants. The aim of our research was to develop a therapeutic and prophylactic regimen for necrotic enteritis in broiler chickens without an antibioticgrowth stimulator.</p></sec><sec><title>Methods</title><p>Methods. Production experience was carried out in the Russian Federation at one of the poultry farms of a large holding company at the cross-country ROSS 308 with the floor content of broiler chickens. Laboratory studies were conducted at the Federal State Institution of Science, State Scientific Center for Applied Microbiology and Biotechnology (FBUN SSC PMB). Based on clinical, pathological, anatomical and laboratory studies on the completed batch of broiler rearing, a necrotic and enteritis diagnosis was made and a treatment plan was drawn up for the next batch of chickens without the use of a feed antibiotic. The drug includes Clindaspectin®, Solamox®, Aviker® T SL and Prodaktiv® Acid Se.</p></sec><sec><title>Results</title><p>Results. Production experience has shown that the consistent introduction of Clindaspectin®, Aviker® T SL, Solamox®, Prodactiv®, Acid Se into the scheme for the complete feeding period allowed achieving the best production indices without the use of a feed antibiotic. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ветеринарная фармакология</kwd><kwd>цыплята-бройлеры</kwd><kwd>птицеводство</kwd><kwd>антибиотики</kwd><kwd>энтерит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>veterinary pharmacology</kwd><kwd>broiler chickens</kwd><kwd>poultry farming</kwd><kwd>antibiotics</kwd><kwd>enteritis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Российская газета, Федеральный выпуск, 09.01.2020, №2 (8056).</mixed-citation><mixed-citation xml:lang="en">Russian newspaper, Federal issue, 09.01.2020, No. 2 (8056) (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">R.M. MC Devitt, John BrookerT. Acamovic, H. C. Sparks, «Necrotic enteritis; a continuing challenge for the poultry industry», World's Poultry Science Journal 62(2), June 2006, 221-247.</mixed-citation><mixed-citation xml:lang="en">R.M. MC Devitt, John BrookerT. Acamovic, H. C. Sparks, «Necrotic enteritis; a continuing challenge for the poultry industry», World's Poultry Science Journal 62(2), June 2006, 221-247.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Маилян Э.С. , «Некротический энтерит кур: современное представление», независимый специалист по птицеводству, ACADEMIA, 2008</mixed-citation><mixed-citation xml:lang="en">Mailian E.S. , “Chicken Necrotizing Enteritis: A Contemporary View,” Independent Poultry Specialist, ACADEMIA, 2008 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Anthony L. Keyburn, Xu-Xia Yan, Trudi L. Bannam, Filip Vfn Immersseel, «Association between avian necrotic enteritis and Clostridium perfringens strains expressing NetB toxin», Julian I. Rood, Robert J. Moore, Vet. Res., 2010, 41:21.</mixed-citation><mixed-citation xml:lang="en">Anthony L. Keyburn, Xu-Xia Yan, Trudi L. Bannam, Filip Vfn Immersseel, «Association between avian necrotic enteritis and Clostridium perfringens strains expressing NetB toxin», Julian I. Rood, Robert J. Moore, Vet. Res., 2010, 41:21.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Joan Smyth,Thomas GMartin, «Disease producing capability of netB positive isolates of C. perfringens recovered from normal chickens and a cow, and netB positive and negative isolates from chickens with necrotic enteritis», J, Veterinary Microbiology November 2010, 146(1-2):76-84.</mixed-citation><mixed-citation xml:lang="en">Joan Smyth,Thomas GMartin, «Disease producing capability of netB positive isolates of C. perfringens recovered from normal chickens and a cow, and netB positive and negative isolates from chickens with necrotic enteritis», J, Veterinary Microbiology November 2010, 146(1-2):76-84.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Dra.Mara Soriano, «Некротический энтерит птицы», инф. журнал,«Veterinaria Digital, 13.03.2019</mixed-citation><mixed-citation xml:lang="en">Dra.Mara Soriano, «Некротический энтерит птицы», инф. журнал,«Veterinaria Digital, 13.03.2019</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Новикова О.Б., «Актуальные болезни птиц бактериальной этиологии», книга: «Организация системы контроля инфекционных болезней, применения антимикробных препаратов и выпуска безопасной продукции», 2018. с. 9-10</mixed-citation><mixed-citation xml:lang="en">Novikova OB, "Actual diseases of birds of bacterial etiology", book: "Organization of the control system of infectious diseases, the use of antimicrobial drugs and the release of safe products", 2018. p. 9-10 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Короткова И.П., «Эпизоотические особенности болезни кур, обусловленной Clostridium perfringens и ее ассоциациями. Разработка рациональных схем лечебно-профилактических мероприятий», Автореферат диссертации на соискание ученой степени кандидата ветеринарных наук, Новосибирск, 2008</mixed-citation><mixed-citation xml:lang="en">Korotkova IP, “Epizootic features of chicken disease caused by Clostridium perfringens and its associations. Development of rational schemes of treatment-and-prophylactic measures ", Abstract of a dissertation for the degree of candidate of veterinary sciences, Novosibirsk, 2008 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Shawkat A. M'Sadeq, Shubiao Wu, Robert A. Swick, Mingan Choct, «Towards the control of necrotic enteritis in broiler chickens with in-feed antibiotics phasing-out worldwide», Anim Nutr .2015 Mar; 1(1): 1–1.Published online 2015 Mar 11.</mixed-citation><mixed-citation xml:lang="en">Shawkat A. M'Sadeq, Shubiao Wu, Robert A. Swick, Mingan Choct, «Towards the control of necrotic enteritis in broiler chickens with in-feed antibiotics phasing-out worldwide», Anim Nutr .2015 Mar; 1(1): 1–1.Published online 2015 Mar 11.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bahram Shojadoost , Andrew R Vince, John F Prescott, «The Successful Experimental Induction of Necrotic Enteritis in Chickens by Clostridium Perfringens: A Critical Review», Vet Res, 2012 Oct 26;43.</mixed-citation><mixed-citation xml:lang="en">Bahram Shojadoost , Andrew R Vince, John F Prescott, «The Successful Experimental Induction of Necrotic Enteritis in Chickens by Clostridium Perfringens: A Critical Review», Vet Res, 2012 Oct 26;43.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
