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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vetpress</journal-id><journal-title-group><journal-title xml:lang="ru">Аграрная наука</journal-title><trans-title-group xml:lang="en"><trans-title>Agrarian science</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-8155</issn><issn pub-type="epub">2686-701X</issn><publisher><publisher-name>Редакция журнала "Аграрная наука"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.32634/0869-8155-2022-359-5-27-31</article-id><article-id custom-type="elpub" pub-id-type="custom">vetpress-2088</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЗООТЕХНИЯ И ВЕТЕРИНАРИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ZOOTECHNICS AND VETERINARY MEDICINE</subject></subj-group></article-categories><title-group><article-title>Показатели антиоксидантной защиты организма молочных коров в зависимости от фазы лактации и физиологического состояния</article-title><trans-title-group xml:lang="en"><trans-title>Indicators of antioxidant protection of the body of dairy cows depending on the phase of lactation and physiological state</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0520-7022</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Боголюбова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogolyubova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Боголюбова Н.В., кандидат биологических наук, ведущий научный сотрудник, заведующая отдела физиологии и биохимии сельскохозяйственных животных</p><p>142132, Московская обл., городской округ Подольск, п. Дубровицы, д. 60</p></bio><bio xml:lang="en"><p>Bogolyubova N.V., Candidate of Biological Sciences, LeadingResearcher</p><p>142132, Moscow region, Podolsk city district, Dubrovitsyvillage, 60</p></bio><email xlink:type="simple">652202@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0228-8901</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рыков</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rykov</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рыков Р.А., старший научный сотрудник отдела физиологии ибиохимии сельскохозяйственных животных</p><p>142132, Московская обл., городской округ Подольск, п. Дубровицы, д. 60</p></bio><bio xml:lang="en"><p>Rykov R.A., Senior Researcherof the Department of Physiologyand Biochemistry of Agricultural Animals</p><p>142132, Moscow region, Podolsk city district, Dubrovitsyvillage, 60</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр животноводства — ВИЖ имени академика Л.К. Эрнста» (ФГБНУ ФИЦ ВИЖ им. Л.К. Эрнста)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center for Animal Husbandry named after Academy Member L.K. Ernst</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>17</day><month>06</month><year>2022</year></pub-date><volume>0</volume><issue>5</issue><fpage>27</fpage><lpage>31</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Боголюбова Н.В., Рыков Р.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Боголюбова Н.В., Рыков Р.А.</copyright-holder><copyright-holder xml:lang="en">Bogolyubova N.V., Rykov R.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vetpress.ru/jour/article/view/2088">https://www.vetpress.ru/jour/article/view/2088</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Научный интерес представляют исследования по оценке про- и антиоксидантного статуса организма продуктивных животных, поскольку они взаимосвязаны со здоровьем, состоянием иммунной и репродуктивной системы.</p></sec><sec><title>Методы</title><p>Методы. С целью изучения показателей антиоксидантной защиты в организме молочных коров в зависимости от месяца лактации и физиологического состояния, в условиях ПЗ «Ладожский» (Краснодарский край) в зимний период 2021 года были сформированы следующие группы коров: сухостойные; лактирующие: 1-го месяца; 2-го месяца; 3-го месяца; 4-го месяца; 5-го месяца; 6–7-го месяца. В крови исследуемых животных определены следующие показатели: концентрация церулоплазмина, продуктов, реагирующих с тиобарбитуровой кислотой, суммарное содержание водорастворимых антиоксидантов, общий антиоксидантный статус, антиокислительная активность сыворотки крови.</p></sec><sec><title>Результаты</title><p>Результаты. Полученные результаты указывают на изменения антиоксидантного статуса в организме коров в зависимости от физиологического состояния и месяца лактации. К 5–6-му месяцам лактации в крови коров наблюдаются максимальные уровни накопления продуктов ПОЛ и снижается уровень церулоплазмина, а поддержание общего антиоксидантного статуса осуществляется за счет других водорастворимых антиоксидантов. Наиболее значимые изменения в изучаемых показателях наблюдаются между сухостойными и лактирующими коровами. Полученные результаты позволят проводить мониторинг состояния здоровья животных и послужат накоплению базы данных для разработки референтных значений показателей антиоксидантного статуса в организме молочных коров в зависимости от физиологического состояния и фазы лактации.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. Studies on the assessment of the pro- and antioxidant status of the body of productive animalsare relevant, since they are interconnected with health, the state of the immune and reproductive systems. There is a steadily growing body of information in the field of oxidative stress in animal husbandry and veterinary medicine, which indicates the general importance of antioxidant defense of the body with impaired health and productivity of ruminants. There is a growing need to translate this knowledge into practical proposals for livestock specialists and veterinarians.</p></sec><sec><title>Methods</title><p>Methods. In order to study the indicators of antioxidant protection in the body of dairy cows depending on the month of lactation and the physiological state, the following groups of cows were formed in the conditions of the PZ Ladozhsky (Krasnodar district) in the winter period of 2021: dry; lactating: 1 month; 2 months; 3 months; 4 months; 5 months; 6–7 months. The following indicators were determined in the blood of the studied animals: the concentration of ceruloplasmin, products reacting with thiobarbituric acid, the total content of water-soluble antioxidants, the general antioxidant status, and the antioxidant activity of blood serum.</p></sec><sec><title>Results</title><p>Results. The results obtained indicate changes in the antioxidant status in the body of cows, depending on the physiological state and month of lactation. By 5–6 months of lactation in the blood of cows the maximum levels of accumulation of LPO products are observed and the level of ceruloplasmin decreases, and the maintenance of the overall antioxidant status is carried out at the expense of other water-soluble antioxidants. The most significant changes in the studied parameters are observed between dry and lactating cows. The results obtained will allow monitoring the health status of animals and will serve as the accumulation of a database for the development of reference values for indicators of the antioxidant status in the body of dairy cows, depending on the physiological state and phase of lactation.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>молочные коровы</kwd><kwd>сухостой</kwd><kwd>месяц лактации</kwd><kwd>антиоксидантный статус</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dairy cows</kwd><kwd>dry cowbane</kwd><kwd>lactation month</kwd><kwd>antioxidant status</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Santos AL, Sinha S, Lindner AB The good, the bad, and the ugly of ROS: New Insights on Aging and Aging-Related Diseases from Eukaryotic and Prokaryotic Model Organisms. Oxid. Med. Cell. 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