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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vetpress</journal-id><journal-title-group><journal-title xml:lang="ru">Аграрная наука</journal-title><trans-title-group xml:lang="en"><trans-title>Agrarian science</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-8155</issn><issn pub-type="epub">2686-701X</issn><publisher><publisher-name>Редакция журнала "Аграрная наука"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.32634/0869-8155-2024-379-2-61-65</article-id><article-id custom-type="elpub" pub-id-type="custom">vetpress-2938</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВЕТЕРИНАРИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>VETERINARY MEDICINE</subject></subj-group></article-categories><title-group><article-title>Влияние ультрадисперсных частиц меди и железа на микробиоценоз кишечника цыплят-бройлеров</article-title><trans-title-group xml:lang="en"><trans-title>Influence of ultrafine particles of copper and iron on the intestinal microbiocenosis of broiler chicken</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0561-7002</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кван</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kvan</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Вилориевна Кван – кандидат биологических наук </p><p>ул. 9 Января, 29, Оренбург, 460000</p></bio><bio xml:lang="en"><p>Olga Vilorievna Kvan</p><p>Сandidate of Biological Sciences</p></bio><email xlink:type="simple">kwan111@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5125-5981</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сизова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sizova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Анатольевна Сизова – доктор биологических наук </p><p>ул. 9 Января, 29, Оренбург, 460000</p></bio><bio xml:lang="en"><p>Elena Anatolyevna Sizova</p><p>Doctor of Biological Sciences</p></bio><email xlink:type="simple">sizova.l78@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9377-7673</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вершинина</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vershinina</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ирина Александровна Вершинина – младший научный сотрудник </p><p>ул. 9 Января, 29, Оренбург, 460000</p></bio><bio xml:lang="en"><p>Irina Alexandrovna Vershinina</p><p>Junior Researcher</p></bio><email xlink:type="simple">gavrish.irina.ogu@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральный научный центр биологических систем и агротехнологий Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center for Biological Systems and Agrotechnologies of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>20</day><month>02</month><year>2024</year></pub-date><volume>0</volume><issue>2</issue><fpage>61</fpage><lpage>65</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кван О.В., Сизова Е.А., Вершинина И.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Кван О.В., Сизова Е.А., Вершинина И.А.</copyright-holder><copyright-holder xml:lang="en">Kvan O.V., Sizova E.A., Vershinina I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vetpress.ru/jour/article/view/2938">https://www.vetpress.ru/jour/article/view/2938</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Изучение бактериального разнообразия кишечника при воздействии различных факторов позволяет исследовать изменения качественного и количественного состава при воздействии различных факторов.</p></sec><sec><title>Методы</title><p>Методы. В работе был изучен бактериальный профиль образцов содержимого слепой кишки цыплят-бройлеров. Для оценки влияния ультрадисперсных частиц Cu и Fe на обмен веществ в организме животных, находящихся на полусинтетическом рационе, было отобрано 120 голов недельных цыплят-бройлеров, которых методом пар-аналогов разделили на 4 группы (n = 30). Во время эксперимента вся птица находилась в одинаковых условиях содержания и кормления. Продолжительность эксперимента составила 28 суток.</p><p>Для решения поставленных задач были использованы цыплята-бройлеры, которым в рацион вносились ультрадисперсные частицы Cu и Fe с целью изучения их влияния на микробиоценоз пищеварительной системы птицы. Методом пар-аналогов было сформировано 4 группы по 30 цыплят-бройлеров в каждой в возрасте 7 дней. Во время проведения исследования условия содержания и кормления были идентичны для всех групп. Исследование было проведено в течение 4 недель. Для кормления готовили полусинтетический рацион (К1) и полусинтетический рацион, дефицитный по микроэлементам, модифицированный авторами (К2).</p></sec><sec><title>Результаты</title><p>Результаты. Было показано, что использование ультрадисперсных частиц меди и железа способствует изменению бактериального сообщества кишечника цыплят-бройлеров. Таким образом, исходя из данных, можно сделать вывод, что облигатные бактерии слепого кишечника птиц могут модулировать уровень накопления химических элементов в теле птицы при внесении различных веществ. Согласно полученным данным ультрадисперсные частицы железа позволили сохранить нормальное разнообразие пищеварительной микробиоты птицы, что было выражено в том числе в уменьшении численности представителей семейства Enterobacteriaceae, в число которых входят представители патогенных и условно-патогенных таксонов, в то время как внесение ультрадисперсных частиц меди способствовало повышению численности представителей данного семейства.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. Studying the bacterial diversity of the intestine under the influence of various factors makes it possible to study changes in the qualitative and quantitative composition under the influence of various factors.</p></sec><sec><title>Methods</title><p>Methods. In our work, we studied the bacterial profile of samples of the contents of the cecum of broiler chickens. To assess the effect of ultrafine particles of Cu and Fe on the metabolism in the body of animals fed a semi-synthetic diet, 120 heads of one-week-old broiler chickens were selected, which were divided into 4 groups (n = 30) using the analog pair method. During the experiment, all birds were under the same housing and feeding conditions. The duration of the experiment was 28 days. To solve the problems, broiler chickens were used, which were supplemented with ultrafine Cu and Fe particles in their diet in order to study their effect on the microbiocenosis of the poultry digestive system. Using the analogue pair method, four groups of 30 broiler chickens each at the age of 7 days were formed. During the study, housing and feeding conditions were identical for all groups. The study was conducted over 4 weeks. For feeding, we prepared a semi-synthetic diet (K1) and a semi-synthetic diet, deficient in microelements, modified by us (K2).</p></sec><sec><title>Results</title><p>Results. The use of ultrafine copper and iron particles has been shown to alter the intestinal bacterial community of broiler chickens. Thus, based on the data, we can conclude that obligate bacteria in the cecum of birds can modulate the level of accumulation of chemical elements in the bird’s body when various substances are introduced. According to the data obtained, ultrafine iron particles made it possible to maintain the normal diversity of the digestive microbiota of poultry, which was expressed, among other things, in a decrease in the number of representatives of the Enterobacteriaceae family, which includes representatives of pathogenic and opportunistic taxa, while the introduction of ultrafine copper particles contributed to an increase in the number of representatives of this family.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>цыплята-бройлеры</kwd><kwd>ультрадисперсные частицы</kwd><kwd>медь</kwd><kwd>железо</kwd><kwd>бактериальный профиль слепой кишки</kwd><kwd>накопление химических элементов</kwd></kwd-group><kwd-group xml:lang="en"><kwd>broiler chickens</kwd><kwd>ultrafine particles</kwd><kwd>copper</kwd><kwd>iron</kwd><kwd>caecum bacterial profile</kwd><kwd>accumulation of chemical elements</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследования выполнены при финансовой поддержке гранта Российского научного фонда № 20-16-00078П. https://rscf.ru/project/23-16-45005/</funding-statement><funding-statement xml:lang="en">The research was carried out with the financial support of the Russian Science Foundation grant No. 20-16-00078P. https://rscf.ru/project/23-16-45005/</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Qi Z., Shi S., Tu J., Li S. 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