Relevance. Mastitis of cattle should be considered as one of the most important and serious problems in dairy cattle breeding. Antibiotic therapy is traditionally considered the most effective method of treatment, however,  despite  the  observed  therapeutic  effect,  relapses  often  occur.  Therefore,  the  search  for  new methods of treatment and prevention of mastitis is extremely relevant.

Methods.  The  objects  of  research  were  black-and-white  cows.  In  the  first  series  of  tests,  according to  the  principle  of  analog  groups,  four  groups  of  cows  of  10  heads  were  selected:  one  control  and three  experimental,  in  the  second  series  –  three  experimental  groups  of  15  heads.  In  the  first  series  of experiments,  we  carried  out  the  prevention  of  cow  mastitis  using  the  immunotropic  drugs  “Prevention-N-A-M” and “Prevention-N-B-S” developed in the Chuvash State Agrarian University, as well as the drug “Mastinol”  used  on  the  farm.  The  drugs  were  applied  to  animals  of  the  experimental  groups  at  a  dose of  10  ml  45–40,  25–20,  15–10  days  before  calving,  in  the  control  group  the  drugs  were  not  used.  In  the second series of experiments, mastitis therapy was carried out according to the following scheme: in the 1st experimental group, “Prevention-N-A-M” was administered to animals, in the 2nd experimental group “Prevention-N-B-S” 40 ml every 24 hours, in the 3rd experimental group “Amoxicillin” 40 ml twice with 48 hours apart.

Results.  It  has  been  established  that  immunotropic  drugs  contribute  to  the  prevention  and  treatment  of cow mastitis, improve hematopoiesis, metabolism, activate factors of nonspecific resistance, reproductive and productive qualities of the body, with a more pronounced — “Prevention-N-A-M” effect.