vetpressАграрная наукаAgrarian science0869-81552686-701XРедакция журнала "Аграрная наука"10.32634/0869-8155-2024-386-9-34-39vetpress-3266Research ArticleВЕТЕРИНАРИЯVETERINARY MEDICINEУровень прооксидантно-антиоксидантного статуса у высокопродуктивных коров при коморбидном течении акушерско-гинекологической и ортопедической патологииLevel of prooxidant-antioxidant status in highly productive cows with comorbid obstetric, gynecological and orthopedic pathologyhttps://orcid.org/0009-0003-4668-2545ЛуцайВ. И.LutsaуV. I.

Владимир Иванович Луцай, доктор ветеринарных наук, заведующий кафедрой ветеринарной медицины

Волоколамское шоссе, 11, Москва, 125080

Vladimir Ivanovich Lutsaу, Doctor of Veterinary Sciences, Head of the Department of Veterinary Medicine

11 Volokolamskoe highway, Moscow, 125080

recaro21@bk.ruhttps://orcid.org/0009-0002-5302-3321СибирцевВ. Д.SibirtsevV. D.

Владимир Дмитриевич Сибирцев, аспирант кафедры ветеринарной медицины

Волоколамское шоссе, 11, Москва, 125080

Vladimir Dmitrievich Sibirtsev, Postgraduate Student of the Department of Veterinary Medicine

11 Volokolamskoe highway, Moscow, 125080

sibircev_vd@mail.ruhttps://orcid.org/0009-0002-6908-2895НефедовА. М.NefedovA. M.

Антон Максимович Нефедов, аспирант кафедры ветеринарной медицины

Волоколамское шоссе, 11, Москва, 125080

Anton Maksimovich Nefedov, Postgraduate Student of the Department of Veterinary Medicine

11 Volokolamskoe highway, Moscow, 125080

goose322@mail.ruhttps://orcid.org/0000-0002-0418-9918РуденкоП. А.RudenkoP. A.

Павел Анатольевич Руденко, доктор ветеринарных наук, профессор Департамента ветеринарной медицины

Волоколамское шоссе, 11, Москва, 125080

ул. им. Миклухо-Маклая, 6, Москва, 117198

Pavel Anatolyevich Rudenko, Doctor of Veterinary Sciences, Professor of the Department of Veterinary Medicine

11 Volokolamskoe highway, Moscow, 125080

6 Miklukho-Maclay Str., Moscow, 117198

pavelrudenko76@yandex.ruРоссийский биотехнологический университет (РОСБИОТЕХ)РоссияRussian Biotechnological UniversitRussian FederationРоссийский биотехнологический университет (РОСБИОТЕХ); Российский университет дружбы народов им. Патриса ЛумумбыРоссияRussian Biotechnological Universit; Peoples’ Friendship University of Russia named after Patrice LumumbaRussian Federation202411102024193439Copyright © Луцай В.И., Сибирцев В.Д., Нефедов А.М., Руденко П.А., 20242024Луцай В.И., Сибирцев В.Д., Нефедов А.М., Руденко П.А.Lutsaу V.I., Sibirtsev V.D., Nefedov A.M., Rudenko P.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vetpress.ru/jour/article/view/3266

Перекисное окисление липидов и антиоксидантная система защиты — это сбалансированная система, отвечающая за обработку и утилизацию липидов в клетках организма. Она играет важную роль в обмене липидов, защите клеток и поддержании здоровья организма в целом. Ее правильное функционирование необходимо для обеспечения оптимальной работы клеток и органов всего организма.

В статье клинико-экспериментально обоснована патогенетическая роль продуктов перекисного окисления липидов и уровня антиоксидантной защиты у коров при эндометритах и гнойнонекротических процессах в области пальца, при коморбидном течении эндометрита и ортопедической патологии. Показано, что полиморбидная манифестация сопровождается более тяжелым течением, чем отдельные заболевания. Установлено, что развитие послеродового эндометрита и гнойнонекротических поражений конечностей у коров сопровождается высокодостоверным увеличением в сыворотке крови продуктов ПОЛ на фоне снижения количества антиоксидантных ферментов, за исключением церулоплазмина. При этом указанные изменения сопровождаются резким скачком при коморбидном течении эндометрита и ортопедической патологии у высокопродуктивных животных.

The lipid peroxidation and antioxidant defense system is a balanced system responsible for the processing and utilization of lipids in the body’s cells. It plays an important role in lipid metabolism, cell protection and overall health of the body. Its proper functioning is necessary to ensure optimal functioning of cells and organs throughout the body. The article clinically and experimentally substantiates the pathogenetic role of lipid peroxidation products and the level of antioxidant protection in cows with endometritis and purulent-necrotic processes in the finger area, as well as with the comorbid course of endometritis and orthopedic pathology. It has been shown that multimorbid manifestation is accompanied by a more severe course than individual diseases. It has been established that the development of postpartum endometritis and purulent-necrotic lesions of the limbs in cows is accompanied by a highly significant increase in lipid peroxidation products in the blood serum against the background of a decrease in the amount of antioxidant enzymes, with the exception of ceruloplasmin. Moreover, these changes are accompanied by a sharp jump in the comorbid course of endometritis and orthopedic pathology in highly productive animals.

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The authors declare that there are no conflicts of interest present.