<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vetpress</journal-id><journal-title-group><journal-title xml:lang="ru">Аграрная наука</journal-title><trans-title-group xml:lang="en"><trans-title>Agrarian science</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-8155</issn><issn pub-type="epub">2686-701X</issn><publisher><publisher-name>Редакция журнала "Аграрная наука"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.32634/0869-8155-2024-386-9-130-135</article-id><article-id custom-type="elpub" pub-id-type="custom">vetpress-3282</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АГРОИНЖЕНЕРИЯ И ПИЩЕВЫЕ ТЕХНОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>AGROENGINEERING AND FOOD TECHNOLOGIES</subject></subj-group></article-categories><title-group><article-title>Наночастицы селена, стабилизированные хитозаном, для обогащения молочной продукции</article-title><trans-title-group xml:lang="en"><trans-title>Selenium nanoparticles stabilized with chitosan for fortifying dairy products</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4701-8633</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блинов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Blinov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андрей Владимирович Блинов, кандидат технических наук, доцент кафедры физики и технологии наноструктур и материалов</p><p>ул. им. Пушкина, 1, Ставрополь, 355002</p><p>ул. им. Пушкина, 1, Ставрополь, 355002</p></bio><bio xml:lang="en"><p>Andrey Vladimirovich Blinov, Candidate of Technical Sciences, Associate Professor of the Department of Physics and Technology of Nanostructures and Materials</p><p>1 Pushkin Str., Stavropol, 355002</p></bio><email xlink:type="simple">blinov.a@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7763-5520</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гвозденко</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gvozdenko</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексей Алексеевич Гвозденко, ассистент кафедры физики и технологии наноструктур и материалов</p><p>ул. им. Пушкина, 1, Ставрополь, 355002</p></bio><bio xml:lang="en"><p>Alexey Alekseevich Gvozdenko, Assistant at the Department of Physics and Technology of Nanostructures and Materials</p><p>1 Pushkin Str., Stavropol, 355002</p></bio><email xlink:type="simple">gvozdenko.1999a@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9321-550X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блинова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Blinova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анастасия Александровна Блинова, кандидат технических наук, доцент кафедры физики и технологии наноструктур и материалов</p><p>ул. им. Пушкина, 1, Ставрополь, 355002</p></bio><bio xml:lang="en"><p>Anastasia Alexandrovna Blinova, Candidate of Technical Sciences,, Associate Professor at the Department of Physics and Technology of Nanostructures and Materials</p><p>1 Pushkin Str., Stavropol, 355002</p></bio><email xlink:type="simple">nastya_bogdanova_88@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2809-4945</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рехман</surname><given-names>З. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rekhman</surname><given-names>Z. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зафар Абдулович Рехман, ассистент кафедры физики и технологии наноструктур и материалов</p><p>ул. им. Пушкина, 1, Ставрополь, 355002</p></bio><bio xml:lang="en"><p>Zafar Abdulovich Rekhman, Assistant at the Department of Physics and Technology of Nanostructures and Materials</p><p>1 Pushkin Str., Stavropol, 355002</p></bio><email xlink:type="simple">zafrehman1027@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6782-2821</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нагдалян</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nagdalian</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андрей Ашотович Нагдалян, кандидат технических наук, старший научный сотрудник научно-исследовательской лаборатории пищевой и промышленной биотехнологии</p><p>ул. им. Пушкина, 1, Ставрополь, 355002</p></bio><bio xml:lang="en"><p>Andrey Ashotovich Nagdalian, Candidate of Technical Sciences, Senior Researcher at the Research Laboratory of Food and Industrial Biotechnology</p><p>1 Pushkin Str., Stavropol, 355002</p></bio><email xlink:type="simple">geniando@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6532-5816</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Леонтьев</surname><given-names>П. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Leontiev</surname><given-names>P. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Павел Сергеевич Леонтьев, студент кафедры физики и технологии наноструктур и материалов</p><p>ул. им. Пушкина, 1, Ставрополь, 355002</p></bio><bio xml:lang="en"><p>Pavel Sergeevich Leontiev, Student at the Department of Physics and Technology of Nanostructures and Materials</p><p>1 Pushkin Str., Stavropol, 355002</p></bio><email xlink:type="simple">arb.acc@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-9852-3055</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аскерова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Askerova</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алина Салмановна Аскерова, студент кафедры физики и технологии наноструктур и материалов</p><p>ул. им. Пушкина, 1, Ставрополь, 355002</p></bio><bio xml:lang="en"><p>Alina Salmanovna Askerova, Student at the Department of Physics and Technology of Nanostructures and Materials</p><p>1 Pushkin Str., Stavropol, 355002</p></bio><email xlink:type="simple">vikalinka04@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0857-5143</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ребезов</surname><given-names>М. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Rebezov</surname><given-names>M. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Максим Борисович Ребезов, доктор сельскохозяйственных наук, кандидат ветеринарных наук, профессор, главный научный сотрудник; доктор сельскохозяйственных наук, кандидат ветеринарных наук, профессор кафедры биотехнологии и пищевых продуктов</p><p>ул. им. Талалихина, 26, Москва, 109316</p><p>ул. им. Карла Либкнехта, 42, Екатеринбург, 620075</p></bio><bio xml:lang="en"><p>Maksim Borisovich Rebezov, Doctor of Agricultural Sciences, Candidate of Veterinary Sciences, Professor, Chief Researcher; Doctor of Agricultural Sciences, Candidate of Veterinary Sciences, Professor of the Department of Biotechnology and Food Products</p><p>26 Talalikhin Str., Moscow, 109316</p><p>42 Karl Liebknecht Str., Yekaterinburg, 620075</p></bio><email xlink:type="simple">rebezov@ya.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Северо-Кавказский федеральный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North Caucasus Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральный научный центр пищевых систем им. В.М. Горбатова Российской академии наук; Уральский государственный аграрный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Gorbatov Research Center for Food Systems; Ural State Agrarian University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>12</day><month>10</month><year>2024</year></pub-date><volume>1</volume><issue>9</issue><fpage>130</fpage><lpage>135</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Блинов А.В., Гвозденко А.А., Блинова А.А., Рехман З.А., Нагдалян А.А., Леонтьев П.С., Аскерова А.С., Ребезов М.Б., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Блинов А.В., Гвозденко А.А., Блинова А.А., Рехман З.А., Нагдалян А.А., Леонтьев П.С., Аскерова А.С., Ребезов М.Б.</copyright-holder><copyright-holder xml:lang="en">Blinov A.V., Gvozdenko A.A., Blinova A.A., Rekhman Z.A., Nagdalian A.A., Leontiev P.S., Askerova A.S., Rebezov M.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vetpress.ru/jour/article/view/3282">https://www.vetpress.ru/jour/article/view/3282</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Одним из решений проблемы дефицита селена является обогащение биодоступными формами селена социально значимых продуктов питания, в частности молочных продуктов. К подобным формам можно отнести наночастицы селена.</p><p>Цель работы — разработка молочного продукта, обогащенного наночастицами селена, стабилизированными хитозаном.</p></sec><sec><title>Методы</title><p>Методы. По данным спектроскопии динамического рассеяния света, образец наночастиц селена, стабилизированный хитозаном, имеет мономодальное распределение по размерам со средним гидродинамическим радиусом частиц 25 нм.</p></sec><sec><title>Результаты</title><p>Результаты. Квантово-химическое моделирование наночастиц селена, стабилизированных хитозаном, позволило установить, что наиболее энергетически выгодным является взаимодействие поверхности наночастиц селена с гидроксильной группой, присоединенной к C3 остатка глюкозамина хитозана. Проводили исследование влияния технологических параметров на стабильность наночастиц селена, стабилизированных хитозаном. Установлено, что повышение времени экспозиции приводит к увеличению среднего гидродинамического радиуса наночастиц селена, стабилизированных хитозаном. В случае pH наблюдается обратная зависимость: частицы с наибольшим средним гидродинамическим радиусом находятся в образцах, имеющих кислую среду (pH ˂ 5). В рамках исследования влияния технологических параметров на стабильность наночастиц селена, стабилизированных хитозаном, установлено, что наночастицы селена, стабилизированные хитозаном, можно использовать в качестве источника селена для продуктов питания, которые имеют нейтральный pH, однако могут подвергаться тепловой обработке при температуре свыше 70 °С в течение 5–15 минут, в частности пастеризованное молоко. Исследование пастеризованного молока, обогащенного наночастицами селена, стабилизированными хитозаном, показало, что значительных изменений титруемой кислотности, поверхностного натяжения и pH молока, среднего гидродинамического радиуса мицелл казеина после обогащения молока не наблюдается. Значение антиоксидантной активности увеличивает на 0,88% — с 6,50 до 7,38%.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. One solution to the problem of selenium deficiency is the enrichment of socially important food products, in particular dairy products, with bioavailable forms of selenium. Such forms include selenium nanoparticles. The aim of the work is to develop a dairy product enriched with selenium nanoparticles stabilized with chitosan.</p></sec><sec><title>Methods</title><p>Methods. According to dynamic light scattering spectroscopy, a sample of selenium nanoparticles stabilized with chitosan has a monomodal size distribution with an average hydrodynamic particle radius of 25 nm.</p></sec><sec><title>Results</title><p>Results. Quantum chemical modeling of selenium nanoparticles stabilized by chitosan has revealed that the most energetically favorable interaction is the interaction of the surface of selenium nanoparticles with the hydroxo group attached to the C3 glucosamine residue of chitosan. A study was conducted of the influence of technological parameters on the stability of selenium nanoparticles stabilized with chitosan. It was found that increasing the exposure time leads to an increase in the average hydrodynamic radius of selenium nanoparticles stabilized by chitosan. In the case of pH, an inverse relationship is observed: particles with the largest average hydrodynamic radius are found in samples with an acidic environment (pH ˂ 5). As part of a study of the influence of technological parameters on the stability of selenium nanoparticles stabilized by chitosan, it was found that selenium nanoparticles stabilized by chitosan can be used as a source of selenium for food products that have a neutral pH, but can be subjected to heat treatment at temperatures above 70 °C in for 5–15 minutes, in particular pasteurized milk. A study of pasteurized milk fortified with selenium nanoparticles stabilized by chitosan showed that there were no significant changes in titratable acidity, surface tension and pH of milk, as well as the average hydrodynamic radius of casein micelles after milk fortification. The value of antioxidant activity increases by 0.88% — from 6.50 to 7.38%.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>эсенциальный микроэлемент</kwd><kwd>селен</kwd><kwd>молоко</kwd><kwd>обогащение</kwd><kwd>наночастицы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Essential microelement</kwd><kwd>selenium</kwd><kwd>milk</kwd><kwd>enrichment</kwd><kwd>nanoparticles</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено за счет гранта Российского научного фонда № 23-16-00120. https://rscf.ru/project/23-16-00120/</funding-statement><funding-statement xml:lang="en">The study was supported by the grant of the Science Foundation No. 23-16-00120. https://rscf.ru/project/23-16-00120/</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Varlamova E.G., Turovsky E.A., Blinova E.V. Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles. International Journal of Molecular Sciences. 2021; 22(19): 10808. https://doi.org/10.3390/ijms221910808</mixed-citation><mixed-citation xml:lang="en">Varlamova E.G., Turovsky E.A., Blinova E.V. Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles. International Journal of Molecular Sciences. 2021; 22(19): 10808. https://doi.org/10.3390/ijms221910808</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Au A., Mojadadi A., Shao J.-Y., Ahmad G., Witting P.K. Physiological Benefits of Novel Selenium Delivery via Nanoparticles. International Journal of Molecular Sciences. 2023; 24(7): 6068. https://doi.org/10.3390/ijms24076068</mixed-citation><mixed-citation xml:lang="en">Au A., Mojadadi A., Shao J.-Y., Ahmad G., Witting P.K. Physiological Benefits of Novel Selenium Delivery via Nanoparticles. International Journal of Molecular Sciences. 2023; 24(7): 6068. https://doi.org/10.3390/ijms24076068</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьев В.И., Воробьев Д.В., Щербакова Е.Н. Влияние Se, Co и J на продуктивность симментальских коров в биогеохимических условиях региона Нижней Волги. Известия Оренбургского государственного аграрного университета. 2013; (2): 93–94. https://www.elibrary.ru/qaqtwl</mixed-citation><mixed-citation xml:lang="en">Vorobyov V.I., Vorobyov D.V., Shcherbakova Ye.N. Effect of Se, Co, and J on simmental cows performance under biogeochemical conditions of Nizhee Povolzhy. Izvestia Orenburg State Agrarian University. 2013; (2): 93–94 (in Russian). https://www.elibrary.ru/qaqtwl</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang J., Saad R., Taylor E.W., Rayman M.P. Selenium and selenoproteins in viral infection with potential relevance to COVID-19. Redox Biology. 2020; 37: 101715. https://doi.org/10.1016/j.redox.2020.101715</mixed-citation><mixed-citation xml:lang="en">Zhang J., Saad R., Taylor E.W., Rayman M.P. Selenium and selenoproteins in viral infection with potential relevance to COVID-19. Redox Biology. 2020; 37: 101715. https://doi.org/10.1016/j.redox.2020.101715</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Некрасов В.И., Скальный А.В., Дубовой Р.М. Роль микроэлементов в повышении функциональных резервов организма человека. Вестник Российской военно-медицинской академии. 2006; (1): 111–113. https://www.elibrary.ru/kwznxl</mixed-citation><mixed-citation xml:lang="en">Nekrasov V.I., Skalny A.V., Dubovoy R.M. The role of microelements in increasing the functional reserves of the human body. Bulletin of the Russian Military Medical Academy. 2006: (1): 111–113 (in Russian). https://www.elibrary.ru/kwznxl</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kuria A. et al. Does dietary intake of selenium protect against cancer? A systematic review and meta-analysis of population-based prospective studies. Critical Reviews in Food Science and Nutrition. 2020; 60(4): 684–694. https://doi.org/10.1080/10408398.2018.1548427</mixed-citation><mixed-citation xml:lang="en">Kuria A. et al. Does dietary intake of selenium protect against cancer? A systematic review and meta-analysis of population-based prospective studies. Critical Reviews in Food Science and Nutrition. 2020; 60(4): 684–694. https://doi.org/10.1080/10408398.2018.1548427</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kuria A. et al. Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis. Critical Reviews in Food Science and Nutrition. 2021; 61(21): 3616–3625. https://doi.org/10.1080/10408398.2020.1803200</mixed-citation><mixed-citation xml:lang="en">Kuria A. et al. Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis. Critical Reviews in Food Science and Nutrition. 2021; 61(21): 3616–3625. https://doi.org/10.1080/10408398.2020.1803200</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Hu W., Zhao C., Hu H., Yin S. Food Sources of Selenium and Its Relationship with Chronic Diseases. Nutrients. 2021; 13(5): 1739. https://doi.org/10.3390/nu13051739</mixed-citation><mixed-citation xml:lang="en">Hu W., Zhao C., Hu H., Yin S. Food Sources of Selenium and Its Relationship with Chronic Diseases. Nutrients. 2021; 13(5): 1739. https://doi.org/10.3390/nu13051739</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou J., Huang K., Lei X.G. Selenium and diabetes — Evidence from animal studies. Free Radical Biology and Medicine. 2013; 65: 1548–1556. https://doi.org/10.1016/j.freeradbiomed.2013.07.012</mixed-citation><mixed-citation xml:lang="en">Zhou J., Huang K., Lei X.G. Selenium and diabetes — Evidence from animal studies. Free Radical Biology and Medicine. 2013; 65: 1548–1556. https://doi.org/10.1016/j.freeradbiomed.2013.07.012</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Huang Y.-C., Combs G.F., Wu T.-L., Zeng H., Cheng W.-H. Selenium status and type 2 diabetes risk. Archives of Biochemistry and Biophysics. 2022; 730: 109400. https://doi.org/10.1016/j.abb.2022.109400</mixed-citation><mixed-citation xml:lang="en">Huang Y.-C., Combs G.F., Wu T.-L., Zeng H., Cheng W.-H. Selenium status and type 2 diabetes risk. Archives of Biochemistry and Biophysics. 2022; 730: 109400. https://doi.org/10.1016/j.abb.2022.109400</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Steinbrenner H., Duntas L.H., Rayman M.P. The role of selenium in type 2 diabetes mellitus and its metabolic comorbidities. Redox Biology. 2022; 50: 102236. https://doi.org/10.1016/j.redox.2022.102236</mixed-citation><mixed-citation xml:lang="en">Steinbrenner H., Duntas L.H., Rayman M.P. The role of selenium in type 2 diabetes mellitus and its metabolic comorbidities. Redox Biology. 2022; 50: 102236. https://doi.org/10.1016/j.redox.2022.102236</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьев В.И., Воробьев Д.В., Полковниченко А.П., Щербакова Е.Н., Захаркина Н.И. Содержание микроэлементов (Сo, Ni, Cu, Se, Mo и Mn) в почвах, растениях и кормах рационов сельхозживотных в Астраханской области. Естественные науки. 2010; (1): 7–12. https://www.elibrary.ru/muznld</mixed-citation><mixed-citation xml:lang="en">Vorobyov V.I., Vorobyov D.V., Polkovnichenko A.P., Shcherbakova E.N., Zakharkina N.I. The maintenance of microcells (Co, Ni, Cu, Se, Mo and Mn) in soils, plants and forages of diets of agricultural animals in the Astrakhan region. Natural Sciences. 2010; (1): 7–12 (in Russian). https://www.elibrary.ru/muznld</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Егорова Е.А., Гмошинский И.В., Зорин С.И., Мазо В.К. Изучение биодоступности различных пищевых форм микроэлемента селена в эксперименте. Вопросы питания. 2006; 75(3): 45–49. https://www.elibrary.ru/htowvl</mixed-citation><mixed-citation xml:lang="en">Egorova E.A., Gmoshinsky I.V., Zorin S.I., Mazo V.K. Studies of bioavailability of different food sources of selenium in experiment. Problems of nutrition. 2006; 75(3): 45–49 (in Russian). https://www.elibrary.ru/htowvl</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Garza-García J.J.O. et al. The Role of Selenium Nanoparticles in Agriculture and Food Technology. Biological Trace Element Research. 2022; 200(5): 2528–2548. https://doi.org/10.1007/s12011-021-02847-3</mixed-citation><mixed-citation xml:lang="en">Garza-García J.J.O. et al. The Role of Selenium Nanoparticles in Agriculture and Food Technology. Biological Trace Element Research. 2022; 200(5): 2528–2548. https://doi.org/10.1007/s12011-021-02847-3</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Chen N. et al. Selenium nanoparticles: Enhanced nutrition and beyond. Critical Reviews in Food Science and Nutrition. 2023; 63(33): 12360–12371. https://doi.org/10.1080/10408398.2022.2101093</mixed-citation><mixed-citation xml:lang="en">Chen N. et al. Selenium nanoparticles: Enhanced nutrition and beyond. Critical Reviews in Food Science and Nutrition. 2023; 63(33): 12360–12371. https://doi.org/10.1080/10408398.2022.2101093</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Храмцов А.Г. и др. Обогащение молочных продуктов биологически активными формами селена. Молочная промышленность. 2023; (6): 49–51. https://doi.org/10.21603/1019-8946-2023-6-13</mixed-citation><mixed-citation xml:lang="en">Khramtsov A.G. et al. Dairy products fortified with biologically active selenium. Dairy industry. 2023; (6): 49–51 (in Russian). https://doi.org/10.21603/1019-8946-2023-6-13</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Bisht N., Phalswal P., Khanna P.K. Selenium nanoparticles: a review on synthesis and biomedical applications. Materials Advances. 2022; 3(3): 1415–1431. https://doi.org/10.1039/D1MA00639H</mixed-citation><mixed-citation xml:lang="en">Bisht N., Phalswal P., Khanna P.K. Selenium nanoparticles: a review on synthesis and biomedical applications. Materials Advances. 2022; 3(3): 1415–1431. https://doi.org/10.1039/D1MA00639H</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Das J.K. et al. Food fortification with multiple micronutrients: impact on health outcomes in general population. Cochrane Database of Systematic Reviews. 2019; (12): CD011400. https://doi.org/10.1002/14651858.CD011400.pub2</mixed-citation><mixed-citation xml:lang="en">Das J.K. et al. Food fortification with multiple micronutrients: impact on health outcomes in general population. Cochrane Database of Systematic Reviews. 2019; (12): CD011400. https://doi.org/10.1002/14651858.CD011400.pub2</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Блинов А.В., Рехман З.А., Гвозденко А.А., Голик А.Б., Нагдалян А.А., Ребезов М.Б. Молочный продукт, обогащенный тройным марганецсодержащим комплексом. Аграрная наука. 2024; (5): 117–123. https://doi.org/10.32634/0869-8155-2024-382-5-117-123</mixed-citation><mixed-citation xml:lang="en">Blinov A.V., Rekhman Z.A., Gvozdenko A.A., Golik A.B., Nagdalуan A.A., Rebezov M.B. Dairy product enriched with triple manganese complex. Agrarian science. 2024; (5): 117–123 (in Russian). https://doi.org/10.32634/0869-8155-2024-382-5-117-123</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Блинов А.В., Рехман З.А., Голик А.Б., Гвозденко А.А., Нагдалян А.А., Ребезов М.Б. Инновационная форма эссенциального микроэлемента меди для обогащения молочной продукции. Аграрная наука. 2024; (4): 153–159. https://doi.org/10.32634/0869-8155-2024-381-4-153-159</mixed-citation><mixed-citation xml:lang="en">Blinov A.V., Rekhman Z.A., Golik A.B., Gvozdenko A.A., Nagdalyan A.A., Rebezov M.B. An innovative form of the essential trace element copper for fortification of dairy products. Agrarian science. 2024; (4): 153–159 (in Russian). https://doi.org/10.32634/0869-8155-2024-381-4-153-159</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Наумова Н.Л., Ребезов М.Б. Микроэлементный статус челябинцев как обоснование развития производства обогащенных продуктов питания. Фундаментальные исследования. 2012; (4–1): 196–200. https://elibrary.ru/pazfxv</mixed-citation><mixed-citation xml:lang="en">Naumova N.L., Rebezov M.B. Microelement status of the population of Chelyabinsk as basis of production fortified foods. Fundamental research. 2012; (4–1): 196–200 (in Russian). https://elibrary.ru/pazfxv</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Abilmazhinov Y., Rebezov M., Fedoseeva N., Nikolaeva N., Sepiashvili E. Enhancing Nutritional Value and Safety in Horse Meat Cutlets with Pumpkin Additives. IOP Conference Series: Earth and Environmental Science. 2023; 1242(1): 012023. https://doi.org/10.1088/1755-1315/1242/1/012023</mixed-citation><mixed-citation xml:lang="en">Abilmazhinov Y., Rebezov M., Fedoseeva N., Nikolaeva N., Sepiashvili E. Enhancing Nutritional Value and Safety in Horse Meat Cutlets with Pumpkin Additives. IOP Conference Series: Earth and Environmental Science. 2023; 1242(1): 012023. https://doi.org/10.1088/1755-1315/1242/1/012023</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Piskov S. et al. Effects of Various Drying Methods on Some Physico-Chemical Properties and the Antioxidant Profile and ACE Inhibition Activity of Oyster Mushrooms (Pleurotus Ostreatus). Foods. 2020; 9(2): 160. https://doi.org/10.3390/foods9020160</mixed-citation><mixed-citation xml:lang="en">Piskov S. et al. Effects of Various Drying Methods on Some Physico-Chemical Properties and the Antioxidant Profile and ACE Inhibition Activity of Oyster Mushrooms (Pleurotus Ostreatus). Foods. 2020; 9(2): 160. https://doi.org/10.3390/foods9020160</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
