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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vetpress</journal-id><journal-title-group><journal-title xml:lang="ru">Аграрная наука</journal-title><trans-title-group xml:lang="en"><trans-title>Agrarian science</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-8155</issn><issn pub-type="epub">2686-701X</issn><publisher><publisher-name>Редакция журнала "Аграрная наука"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.32634/0869-8155-2025-390-01-50-56</article-id><article-id custom-type="elpub" pub-id-type="custom">vetpress-3404</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВЕТЕРИНАРИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>VETERINARY MEDICINE</subject></subj-group></article-categories><title-group><article-title>Цитоархитектоника и морфофункциональные показатели дермальных мастоцитом в области лицевого скелета у собак</article-title><trans-title-group xml:lang="en"><trans-title>Cytoarchitectonics and morphofunctional parameters of dermal mastocytomas in the area of the facial skeleton in dogs</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9322-1464</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Меликова</surname><given-names>Ю. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Melikova</surname><given-names>Ju. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юлия Николаевна Меликова, кандидат ветеринарных наук, доцент кафедры болезней мелких домашних, лабораторных и экзотических животных</p><p>Волоколамское шоссе, 11, Москва, 125080</p></bio><bio xml:lang="en"><p>Julia Nikolaevna Melikova, Candidate of Veterinary Sciences, Associate Professor of the Department of Diseases of Small Domestic, Laboratory and Exotic Animals</p><p>11 Volokolamskoye highway, Moscow, 125080</p></bio><email xlink:type="simple">melikovayn@mgupp.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-4723-1423</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чечнева</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chechneva</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анастасия Вячеславовна Чечнева, кандидат ветеринарных наук, доцент кафедры болезней мелких домашних, лабораторных и экзотических животных</p><p>Волоколамское шоссе, 11, Москва, 125080</p></bio><bio xml:lang="en"><p>Anastasia Vyacheslavovna Chechneva, Candidate of Veterinary Sciences, Associate Professor of the Department of Diseases of Small Domestic, Laboratory and Exotic Animals</p><p>11 Volokolamskoye highway, Moscow, 125080</p></bio><email xlink:type="simple">chechnevaav@mgupp.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-8281-4320</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Верницкая</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vernitskaya</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Людмила Андреевна Верницкая, аспирант кафедры болезней мелких домашних, лабораторных и экзотических животных</p><p>Волоколамское шоссе, 11, Москва, 125080</p></bio><bio xml:lang="en"><p>Liudmila Andreevna Vernitskaya, Postgraduate Student of the Department of Diseases of Small Domestic, Laboratory and Exotic Animals</p><p>11 Volokolamskoye highway, Moscow, 125080</p></bio><email xlink:type="simple">vet_pah_vern@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский биотехнологический университет (РОСБИОТЕХ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Biotechnological University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>28</day><month>01</month><year>2025</year></pub-date><volume>1</volume><issue>1</issue><fpage>50</fpage><lpage>56</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Меликова Ю.Н., Чечнева А.В., Верницкая Л.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Меликова Ю.Н., Чечнева А.В., Верницкая Л.А.</copyright-holder><copyright-holder xml:lang="en">Melikova J.N., Chechneva A.V., Vernitskaya L.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vetpress.ru/jour/article/view/3404">https://www.vetpress.ru/jour/article/view/3404</self-uri><abstract><p>Результаты анализа исследования распространенности первичных спонтанных дермальных мастоцитом у собак в области лицевого скелета были проведены в 2021–2024 году.Объектом исследования являлись 63 собаки с первичными спонтанными дермальными мастоцитомами, подтвержденными гистологически.Цели работы — изучение морфофункциональных показателей дермальных мастоцитом в области лицевого скелета у собак и оценка их степени злокачественности.В ходе исследования определяли степень злокачественности по двум общепринятым классификациям — Kupel и Patnaik — важного прогностического критерия оценки первичных спонтанных мастоцитом в области лицевого скелета у собак. По результатам гистологического исследования первичных спонтанных мастоцитом в области лицевого скелета у собак по классификации Kupel было выявлено, что менее агрессивные опухоли встречаются чаще и составляют 65,08%, тогда как высокоагрессивные мастоцитомы встречаются в 34,92% случаев, по данным авторов, при этом по классификации Patnaik высокодифференцированные мастоцитомы выявлены в 20,63% случаев, умеренно дифференцированные наблюдали в 49,21% случаев, низкодифференцированные — в 30,16% случаев. Из полученных сведений о классификации дермальных мастоцитом следует вывод о том, что большинство умеренно дифференцированных мастоцитом по Patnaik (G2) являются высокодифференцированными по Kupel (G1), что влияет на прогностическую оценку и выбор тактики лечения больных собак.</p></abstract><trans-abstract xml:lang="en"><p>The results of the analysis of the prevalence of primary spontaneous dermal mast cell tumors in dogs in the facial skeleton area study was conducted in 2021–2024. The object of the study were 63 dogs with primary spontaneous dermal mast cell tumors, confirmed histologically.The purpose of the work is to study the morphofunctional indicators of dermal mast cell tumors in the facial skeleton area in dogs and to assess their degree of malignancy.During the study, the degree of malignancy was determined according to two generally accepted classifications, according to Kupel and Patnaik — an important prognostic criterion for assessing primary spontaneous mast cell tumors in the facial skeleton area in dogs.According to the results of histological examination of primary spontaneous mast cell tumors in the facial skeleton area in dogs according to the Kupel classification, it was revealed that less aggressive tumors are more common and account for 65.08%, while highly aggressive mast cell tumors occur in 34.92% of cases according to our data, while according to the Patnaik classification, highly differentiated mast cell tumors were detected in 20.63% of cases, moderately differentiated were observed in 49.21% of cases, and poorly differentiated — in 30.16% of cases. From the obtained information on the classification of dermal mast cell tumors, it follows that the majority of moderately differentiated mast cell tumors according to Patnaik (G2) are highly differentiated according to Kupel (G1), which affects the prognostic assessment and choice of treatment tactics for sick dogs.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>тучные клетки</kwd><kwd>злокачественное новообразование</kwd><kwd>опухоль</kwd><kwd>неоплазия</kwd><kwd>мастоцитома</kwd><kwd>гистология</kwd><kwd>собака</kwd></kwd-group><kwd-group xml:lang="en"><kwd>mast cells</kwd><kwd>malignant neoplasm</kwd><kwd>tumor</kwd><kwd>neoplasia</kwd><kwd>mastocytoma</kwd><kwd>histology</kwd><kwd>dog</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследования проведены при поддержке Министерства науки и высшего образования Российской Федерации (регистрационный № FSMF-2022-0003 темы государственного задания).</funding-statement><funding-statement xml:lang="en">The research was carried out with the support of the Ministry of Science and Higher Education of the Russian Federation (registration No. FSMF-2022-0003 topics of the state assignment).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Vail D.M., Thamm D.H., Liptak J.M. 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