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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vetpress</journal-id><journal-title-group><journal-title xml:lang="ru">Аграрная наука</journal-title><trans-title-group xml:lang="en"><trans-title>Agrarian science</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-8155</issn><issn pub-type="epub">2686-701X</issn><publisher><publisher-name>Редакция журнала "Аграрная наука"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.32634/0869-8155-2025-394-05-41-47</article-id><article-id custom-type="elpub" pub-id-type="custom">vetpress-3617</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВЕТЕРИНАРИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>VETERINARY MEDICINE</subject></subj-group></article-categories><title-group><article-title>Эффективность терапии высокопродуктивных коров при коморбидном течении акушерско-гинекологической и ортопедической патологии</article-title><trans-title-group xml:lang="en"><trans-title>Efficiency of therapy of highly productive cows with comorbid obstetric-gynecological and orthopedic pathology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-4668-2545</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Луцай</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Lutsaу</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владимир Иванович Луцай, доктор ветеринарных наук, заведующий кафедрой ветеринарной медицины</p><p>Волоколамское шоссе, 11, Москва, 125080</p></bio><bio xml:lang="en"><p>Vladimir Ivanovich Lutsaу, Doctor of Veterinary Sciences, Head of the Department of Veterinary Medicine</p><p>11 Volokolamskoe highway, Moscow, 125080</p></bio><email xlink:type="simple">recaro21@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0418-9918</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Руденко</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudenko</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Павел Анатольевич Руденко, доктор ветеринарных наук, профессор кафедры ветеринарной медицины; профессор департамента ветеринарной медицины</p><p>Волоколамское шоссе, 11, Москва, 125080</p><p>ул. Миклухо-Маклая, 6, Москва, 117198</p></bio><bio xml:lang="en"><p>Pavel Anatolyevich Rudenko, Doctor of Veterinary Sciences, Professor of the Department of Veterinary Medicine; Professor of the Department of Veterinary Medicine</p><p>11 Volokolamskoe highway, Moscow, 125080</p><p>6 Miklukho-Maclay Str., Moscow, 117198</p></bio><email xlink:type="simple">pavelrudenko76@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-5302-3321</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сибирцев</surname><given-names>В. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Sibirtsev</surname><given-names>V. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владимир Дмитриевич Сибирцев, аспирант кафедры ветеринарной медицины</p><p>Волоколамское шоссе, 11, Москва, 125080</p></bio><bio xml:lang="en"><p>Vladimir Dmitrievich Sibirtsev, Рostgraduate Student of the Department of Veterinary Medicine</p><p>11 Volokolamskoe highway, Moscow, 125080</p></bio><email xlink:type="simple">sibircev_vd@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-6908-2895</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нефедов</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Nefedov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Антон Максимович Нефедов, аспирант кафедры ветеринарной медицины</p><p>Волоколамское шоссе, 11, Москва, 125080</p></bio><bio xml:lang="en"><p>Anton Maksimovich Nefedov, Рostgraduate Student of the Department of Veterinary Medicine</p><p>11 Volokolamskoe highway, Moscow, 125080</p></bio><email xlink:type="simple">goose322@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский биотехнологический университет (РОСБИОТЕХ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Biotechnological University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский биотехнологический университет (РОСБИОТЕХ); Российский университет дружбы народов им. Патриса Лумумбы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Biotechnological University; Patrice Lumumba Peoples’ Friendship University of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>16</day><month>05</month><year>2025</year></pub-date><volume>0</volume><issue>5</issue><fpage>41</fpage><lpage>47</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Луцай В.И., Руденко П.А., Сибирцев В.Д., Нефедов А.М., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Луцай В.И., Руденко П.А., Сибирцев В.Д., Нефедов А.М.</copyright-holder><copyright-holder xml:lang="en">Lutsaу V.I., Rudenko P.A., Sibirtsev V.D., Nefedov A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vetpress.ru/jour/article/view/3617">https://www.vetpress.ru/jour/article/view/3617</self-uri><abstract><p>В ветеринарной практике существует проблема коморбидного течения различных заболеваний, которые вызваны ассоциациями условно-патогенной микрофлоры, присутствующей в фермерских биоценозах. Коморбидное течение гинекологических и ортопедических патологий у коров наносит значительный экономический ущерб, что связано с уменьшением молочной продуктивности и увеличением расходов на диагностику, лечение и профилактику ветеринарных мероприятий. Поэтому в связи с высоким уровнем нарушений репродуктивной функции и гнойно-некротических поражений в области копытец у коров необходимо искать эффективные и патогенетически обоснованные методы терапевтического воздействия на эти патологии. Авторами проведен клинико-морфологический контроль эффективности лечения различными схемами высокопродуктивных коров при коморбидном течении послеродового эндометрита и ортопедической патологии. Установлено, что наиболее эффективной схемой терапии высокопродуктивных животных с коморбидным течением послеродового острого гнойно-катарального эндометрита и гнойно-некротических поражений в области пальцев является лечение коров I опытной группы. Об этом свидетельствуют отсутствие осложнений, более быстрое общее клиническое улучшение на 8,67 суток (р &lt; 0,001) и возникновение половой течки на 37,2 суток (р &lt; 0,001) раньше при сравнении с базовым лечением. Эффективность лечения коров I опытной группы подкреплена позитивной динамикой стабилизации в крови уровня показателей HGB, RBC, PLT и WBC при сравнении с показателями животных других опытных групп.</p></abstract><trans-abstract xml:lang="en"><p>In veterinary practice, there is a problem of comorbid course of various diseases, which are caused by associations of opportunistic microflora present in farm biocenoses. Comorbid course of gynecological and orthopedic pathologies in cows causes significant economic damage, which is associated with a decrease in milk productivity and an increase in the cost of diagnostics, treatment and prevention of veterinary measures. Therefore, due to the high level of reproductive dysfunction and purulent-necrotic lesions in the hooves of cows, it is necessary to look for effective and pathogenetically substantiated methods of therapeutic action on these pathologies. In this manuscript, clinical and morphological control of the effectiveness of treatment with various schemes of highly productive cows with comorbid course of postpartum endometritis and orthopedic pathology is carried out. It has been established that the most effective treatment regimen for highly productive animals with comorbid postpartum acute purulent-catarrhal endometritis and purulent-necrotic lesions in the toe area is the treatment of cows in the 1st experimental group. This is evidenced by the absence of complications, faster overall clinical improvement by 8.67 days (p &lt; 0.001) and the occurrence of estrus 37.2 days (p &lt; 0.001) earlier, when compared with the basic treatment. The effectiveness of the treatment of cows in the 1st experimental group is supported by the positive dynamics of stabilization of the blood levels of HGB, RBC, PLT and WBC, when compared with the indicators of animals in other experimental groups.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>высокопродуктивные коровы</kwd><kwd>репродуктивный цикл</kwd><kwd>эндометрит</kwd><kwd>гнойно-некротические поражения конечностей</kwd><kwd>коморбидное течение</kwd><kwd>терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>highly productive cows</kwd><kwd>reproductive cycle</kwd><kwd>endometritis</kwd><kwd>purulent-necrotic lesions of the extremities</kwd><kwd>comorbid course</kwd><kwd>therapy</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено за счет гранта Российского научного фонда № 24-26-00172. https://rscf.ru/project/24-26-00172/</funding-statement><funding-statement xml:lang="en">The research was supported by the Russian Science Foundation grant No. 24-26-00172. https://rscf.ru/project/24-26-00172/</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Rudenko A., Glamazdin I., Lutsay V., Sysoeva N., Tresnitsky S., Rudenko P. 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