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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vetpress</journal-id><journal-title-group><journal-title xml:lang="ru">Аграрная наука</journal-title><trans-title-group xml:lang="en"><trans-title>Agrarian science</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-8155</issn><issn pub-type="epub">2686-701X</issn><publisher><publisher-name>Редакция журнала "Аграрная наука"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.32634/0869-8155-2025-396-07-23-28</article-id><article-id custom-type="elpub" pub-id-type="custom">vetpress-3736</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВЕТЕРИНАРИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>VETERINARY MEDICINE</subject></subj-group></article-categories><title-group><article-title>Медикаментозная терапия открытой формы пиометры у собак: сравнительная оценка эффективности применения «Эстрофантина» в виде монотерапии и в комбинации с «Ализином»</article-title><trans-title-group xml:lang="en"><trans-title>Drug therapy of the open pyometra in dogs: a comparative assessment of the effectiveness of “Estrophanthin” in monotherapy and in combination with “Alizine”</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-3467-2495</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Салагаева</surname><given-names>Е. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Salagaeva</surname><given-names>E. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елизавета Кирилловна Салагаева, ассистент</p><p>ул. Тимирязевская, 49, Москва, 127550</p></bio><bio xml:lang="en"><p>Elizaveta Kirillovna Salagaeva, Аssistant</p><p>49 Timiryazevskaya Str., Moscow, 127434</p></bio><email xlink:type="simple">e.salagaeva@rgaumcxa.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2501-1235</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дюльгер</surname><given-names>Г. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Dyulger</surname><given-names>G. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Георгий Петрович Дюльгер, доктор ветеринарных наук, профессор</p><p>ул. Тимирязевская, 49, Москва, 127550</p></bio><bio xml:lang="en"><p>Georgе Petrovich Dyulger, Doctor of Veterinary Sciences, Professor</p><p>49 Timiryazevskaya Str., Moscow, 127434</p></bio><email xlink:type="simple">dulger@rgau-msha.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский государственный аграрный университет — Московская&#13;
сельскохозяйственная академия им. К.А. Тимирязева</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian State Agrarian University — Moscow Timiryazev Agricultural&#13;
Academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>31</day><month>07</month><year>2025</year></pub-date><volume>0</volume><issue>7</issue><fpage>23</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Салагаева Е.К., Дюльгер Г.П., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Салагаева Е.К., Дюльгер Г.П.</copyright-holder><copyright-holder xml:lang="en">Salagaeva E.K., Dyulger G.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vetpress.ru/jour/article/view/3736">https://www.vetpress.ru/jour/article/view/3736</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Пиометра — распространенная и потенциально опасная для жизни и здоровья собак патология матки. Основным методом лечения пиометры у собак признана пановариогистерэктомия с системной антибиотикотерапией. Органосохранный подход у молодых и ценных в племенном отношении животных обеспечивается при медикаментозном лечении сук с неосложненной формой заболевания.</p></sec><sec><title>Методы</title><p>Методы. Исследование проведено на собаках с открытой формой пиометры, разделенных на две сопоставимые группы согласно схеме медикаментозной терапии: I группу составили больные собаки (n = 6), которым применялся «Эстрофантин®» (д. в. клопростенол), II группу — больные собаки (n = 6), получавшие наряду с «Эстрофантином» антигестагенный препарат «Ализин®» (д. в. аглепристон). В обеих группах применялась системная антибиотикотерапия. Диагноз на пиометру ставили совокупно, исходя из данных анамнеза, клинико-гинекологического осмотра, трансабдоминального ультразвукового исследования (УЗИ) внутренних половых органов, ультразвуковой допплерографии (УЗДГ) сосудов матки и результатов клинического и биохимического анализа крови.</p></sec><sec><title>Результаты</title><p>Результаты. При комплексном клинико-эхографическом обследовании подопытных собак на 21–28-е сутки опыта полная ремиссии симптомов пиометры в группе комбинированной терапии составила 100% (против 66,67% в группе монотерапии «Эстрофантином»). Восстановление половой цикличности отмечено в группе комбинированной простагландин-антигестагенной терапии (II группа) выше на 33,3% (83,3% против 50,0%), чем при монотерапии «Эстрофантином» (I группа). Рецидивирование пиометры зафиксировали в I группе только у одной собаки (16,67%), тогда как во II группе частота рецидива пиометры была в 2 раза выше и составила 33,33%.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. Pyometra is a common and potentially life–threatening pathology of the uterus in dogs. Panovariohysterectomy with systemic antibiotic therapy is recognized as the main method of treating pyometra in dogs. An organ-preserving approach in young and valuable breeding animals is provided by the drug treatment of bitches with an uncomplicated form of the disease.</p></sec><sec><title>Methods</title><p>Methods. The study was conducted on dogs with an open pyometra, divided into 2 comparable groups according to the scheme of drug therapy: I group consisted of sick dogs (n = 6) who received “Estrophanthin®” (a. s. cloprostenol), II group — sick dogs (n = 6) who received the antigestagenic drug “Estrophanthin®” along with “Alizine®” (a. s. aglepriston). Systemic antibiotic therapy was also used in both groups. The diagnosis on the pyometer was made collectively, based on the data of anamnesis, clinical and gynecological examination, transabdominal ultrasound (ultrasound) of the internal genitalia, ultrasound Dopplerography (ultrasound) of the uterine vessels and the results of clinical and biochemical blood tests.</p></sec><sec><title>Results</title><p>Results. During a comprehensive clinical and echographic examination of experimental dogs on days 21–28 of the experiment, complete remission of pyometra symptoms in the combination therapy group was 100% (versus 66.67% in the “Estrophantine” monotherapy group). Recovery of sexual cyclicity was noted in the group of combined prostaglandin-antigestogen therapy (II group) by 33.3% higher (83.3% versus 50.0%) than with Estrophantine monotherapy (I group). Pyometra recurrence was recorded in I group in only one dog (16.67%), whereas in II group the frequency of pyometra recurrence was twice as high and amounted to 33.33%.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>собаки</kwd><kwd>пиометра</kwd><kwd>медикаментозное лечение</kwd><kwd>клопростенол</kwd><kwd>аглепристон</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dogs</kwd><kwd>pyometra</kwd><kwd>drug treatment</kwd><kwd>cloprostenol</kwd><kwd>aglepriston</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Дюльгер Г.П., Колядина Н.И., Салагаева Е.К., Крамарь Н.Н. Современные аспекты диагностики и терапии пиометры у домашних плотоядных. В.И. Трухачев (ред.). Сохранение породного разнообразия, репродуктивного и продуктивного долголетия собак в условиях современного общества. М.: Российский государственный аграрный университет — МСХА им. К.А. 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