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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vetpress</journal-id><journal-title-group><journal-title xml:lang="ru">Аграрная наука</journal-title><trans-title-group xml:lang="en"><trans-title>Agrarian science</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-8155</issn><issn pub-type="epub">2686-701X</issn><publisher><publisher-name>Редакция журнала "Аграрная наука"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.32634/0869-8155-2025-399-10-8-16</article-id><article-id custom-type="elpub" pub-id-type="custom">vetpress-3857</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВЕТЕРИНАРИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>VETERINARY MEDICINE</subject></subj-group></article-categories><title-group><article-title>Изучение отдельных морфометрических особенностей стенки тонкой кишки у цыплят-бройлеров в условиях технологических стрессов в промышленном птицеводстве и на фоне их фармакологической профилактики</article-title><trans-title-group xml:lang="en"><trans-title>Study of individual morphometric features of the small intestine wall in broiler chickens under conditions of technological stress in industrial poultry farming and against the background of their pharmacological prevention</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8496-2810</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мифтахутдинов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Miftakhutdinov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алевтин Викторович Мифтахутдинов - доктор биологических наук, профессор, заведующий кафедрой морфологии, физиологии и фармакологии,</p><p>ул. им. Гагарина, 13, Троицк, 457100</p></bio><bio xml:lang="en"><p>Alevtin Viktorovich Miftakhutdinov - Doctor of Biological Sciences, Professor, Head of theDepartment of Morphology, Physiology and Pharmacology,</p><p>13 Gagarin Str., Troitsk, 457100</p></bio><email xlink:type="simple">nirugavm@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ноговицина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nogovitsina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Александровна Ноговицина - кандидат биологических наук, доцент кафедры морфологии, физиологии и фармакологии,</p><p>ул. им. Гагарина, 13, Троицк, 457100</p></bio><bio xml:lang="en"><p>Elena Aleksandrovna Nogovitsina - Candidate of Biological Sciences, Associate Professor of the Department of Morphology, Physiology and Pharmacology,</p><p>13 Gagarin Str., Troitsk, 457100</p></bio><email xlink:type="simple">madzuga74@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Акентьева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Akentieva</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елизавета Викторовна Акентьева - студент,</p><p>ул. им. Гагарина, 13, Троицк, 457100</p></bio><bio xml:lang="en"><p>Elizaveta Viktorovna Akentieva - Student,</p><p>13 Gagarin Str., Troitsk, 457100</p></bio><email xlink:type="simple">akenteva02@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шакирова</surname><given-names>Ю. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Shakirova</surname><given-names>Yu. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юлия Сабирьяновна Шакирова - студент,</p><p>ул. им. Гагарина, 13, Троицк, 457100</p></bio><bio xml:lang="en"><p>Yulia Sabiryanovna Shakirova - Student,</p><p>13 Gagarin Str., Troitsk, 457100</p></bio><email xlink:type="simple">t.kmpt@sursau.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Южно-Уральский государственный аграрный университет<country>Россия</country></aff><aff xml:lang="en">South Ural State Agrarian University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>02</day><month>11</month><year>2025</year></pub-date><volume>0</volume><issue>10</issue><fpage>8</fpage><lpage>16</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мифтахутдинов А.В., Ноговицина Е.А., Акентьева Е.В., Шакирова Ю.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Мифтахутдинов А.В., Ноговицина Е.А., Акентьева Е.В., Шакирова Ю.С.</copyright-holder><copyright-holder xml:lang="en">Miftakhutdinov A.V., Nogovitsina E.A., Akentieva E.V., Shakirova Y.S.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vetpress.ru/jour/article/view/3857">https://www.vetpress.ru/jour/article/view/3857</self-uri><abstract><p>В работе приведены данные морфометрических исследований структур стенки тонкой кишки цыплят-бройлеров, особенно слоев ее слизистой оболочки в условиях действия стрессоров, а также на фоне фармакологической его профилактики фармакологическим средством «Пик-антистресс». Первая группа (контрольная) получала полнорационный комбикорм, вторая (1-я опытная) — полнорационный комбикорм, включающий антистрессовую кормовую добавку «Пик-антистресс» в дозе 1,27 кг на 1 т корма за 5 суток до убоя, третья (2-я опытная) — кормовую добавку «Пик-антистресс» с включением в состав L-карнитина в общей дозе 1,7 кг на 1 т корма за 5 суток до убоя. При непродолжительном действии технологических стрессов на организм экспериментальной птицы наблюдали изменение морфометрических показателей стенки тонкой кишки, сопровождающееся уменьшением толщины слизистой оболочки, величины (высоты и ширины) ворсинок. Под влиянием фармакологической профилактики — кормовой добавки «Пикантистресс» — и в сочетании с L-карнитином в опытных группах отмечали увеличение толщины оболочек стенки тонкой кишки, особенно слизистой и мышечной, что дает синергетический эффект, L-карнитин потенцирует действие фармацевтических субстанций, включенных в состав средства «Пик-антистресс». Под действием антистрессовой терапии происходит значительное увеличение слизистой оболочки, особенно двенадцатиперстной кишки и тощей кишки за счет увеличения высоты ворсинок и уменьшения диаметра крипт и высоты эпителия.</p></abstract><trans-abstract xml:lang="en"><p>The paper presents data from morphometric studies of the structures of the wall of the small intestine of broiler chickens, especially the layers of its mucous membrane under the influence of stressors, as well as against the background of pharmacological prophylaxis with the pharmacological agent “Peak-antistress”. The first group (control) received complete compound feed, the second (1st experimental) received complete compound feed, including the anti-stress feed additive “Peak-antistress” at a dose of 1.27 kg per 1 ton of feed 5 days before slaughter, the third (2nd experimental) received the feed additive “Peak-antistress” with the inclusion of It contains L-carnitine in a total dose of 1.7 kg per 1 ton of feed 5 days before slaughter. Under the short-term effect of technological stresses on the body of the experimental bird, a change in the morphometric parameters of the small intestine wall was observed, accompanied by a decrease in the thickness of the mucous membrane, the size (height and width) of the villi. Under the influence of pharmacological prophylaxis — the feed additive “Peak-antistress” — and in combination with L-carnitine in the experimental groups, an increase in the thickness of the membranes of the wall of the small intestine, especially mucosa and muscle, was noted, which gives a synergistic effect, L-carnitine potentiates the action of pharmaceutical substances included in the composition of the drug “Peakantistress”. Under the influence of anti-stress therapy, a significant increase in the mucous membrane occurs, especially the duodenum and jejunum due to an increase in the height of the villi and a decrease in the diameter of the crypts and the height of the epithelium.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>стресс</kwd><kwd>цыплята-бройлеры</kwd><kwd>морфометрия</kwd><kwd>тонкая кишка</kwd><kwd>кормовая добавка «Пик-антистресс»</kwd><kwd>L-карнитин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>stress</kwd><kwd>broiler chickens</kwd><kwd>morphometry</kwd><kwd>small intestine</kwd><kwd>feed additive “PIKantistress”</kwd><kwd>L-carnitine</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Исследование выполнено за счет гранта Российского научного фонда № 24-26-20039. https://rscf.ru/project/24-26-20039.</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>The study was funded by the Russian Science Foundation grant No. 24-26-20039. https://rscf.ru/project/24-26-20039.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гласкович М.А. Стрессы в условиях интенсивного выращивания птицы. Наше сельское хозяйство. 2024; 2(322): 18–21. https://elibrary.ru/ruywoo</mixed-citation><mixed-citation xml:lang="en">Glaskovich M.A. Stress in conditions of intensive poultry farming. Nashe sel’skoye khozyaystvo. 2024; 2(322): 18–21 (in Russian). https://elibrary.ru/ruywoo</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Смирнова В.И. Рационализация системы содержания животных для снижения стрессовых факторов и повышения продуктивности. Ресурсосберегающие технологии и технические средства для производства продукции растениеводства и животноводства: Сборник статей X Международной научно-практической конференции. Пенза: Пензенский государственный аграрный университет. 2025; 236–239. https://elibrary.ru/mniics</mixed-citation><mixed-citation xml:lang="en">Smirnova V.I. Rationalization of the animal husbandry system to reduce stress factors and increase productivity. Resource-saving technologies and technical means for the production of crop and livestock products: Collection of articles of the X International scientific and practical conference. Penza: Penza State Agrarian University. 2025; 236–239 (in Russian). https://elibrary.ru/mniics</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Пергамент А.Д., Фалынскова Н.П. Влияние стресса на биохимические показатели крови у животных. Современные научные тенденции в ветеринарии: Сборник статей IV Международной научно-практической конференции. Пенза: Пензенский государственный аграрный университет. 2025; 156–160. https://elibrary.ru/rcgicg</mixed-citation><mixed-citation xml:lang="en">Pergament A.D., Falynskova N.P. Influence of stress on biochemical indicators in animals. Modern scientific trends in veterinary medicine: Collection of articles of the IV International scientific and practical conference. Penza: Penza State Agrarian University. 2025; 156–160 (in Russian). https://elibrary.ru/rcgicg</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Фисинин В.И., Кавтарашвили А.Ш. Тепловой стресс у птицы. Сообщение I. Опасность, физиологические изменения в организме, признаки и проявления (обзор). Сельскохозяйственная биология. 2015; 50(2): 162–171. https://doi.org/10.15389/agrobiology.2015.2.162rus</mixed-citation><mixed-citation xml:lang="en">Fisinin V.I., Kavtarashvili A.Sh. Heat stress in poultry. I. Danger, related physiological changes and symptoms (review). Agricultural Biology. 2015; 50(2): 162–171 (in Russian). https://doi.org/10.15389/agrobiology.2015.2.162eng</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Кавтарашвили А.Ш. Колокольникова Т.Н. Физиология и продуктивность птицы при стрессе (обзор). Сельскохозяйственная биология. 2010; 45(4): 25–37. https://elibrary.ru/mukcuf</mixed-citation><mixed-citation xml:lang="en">Kavtarashvili A.Sh., Kolokolnikova T.N. Physiology and productivity of poultry under stress (review). Agricultural Biology. 2010; 45(4): 25–37 (in Russian). https://elibrary.ru/mukcuf</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gorelik O.V. et al. Dynamics of Hematological Indicators of Chickens under Stress-Inducing Influence. Ukrainian Journal of Ecology. 2020; 10(2): 264–267. https://elibrary.ru/xvhtey</mixed-citation><mixed-citation xml:lang="en">Gorelik O.V. et al. Dynamics of Hematological Indicators of Chickens under Stress-Inducing Influence. Ukrainian Journal of Ecology. 2020; 10(2): 264–267. https://elibrary.ru/xvhtey</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Gorelik O.V. et al. Influence of Transport Stress on the Adaptation Potential of Chicken. Ukrainian Journal of Ecology. 2020; 10(2): 260–263. https://elibrary.ru/leezaj</mixed-citation><mixed-citation xml:lang="en">Gorelik O.V. et al. Influence of Transport Stress on the Adaptation Potential of Chicken. Ukrainian Journal of Ecology. 2020; 10(2): 260–263. https://elibrary.ru/leezaj</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Харлап С.Ю., Лоретц О.Г., Горелик О.В., Ребезов М.Б., Максимюк Н.Н. Изменение лейкоцитарных индексов при оценке воздействия стресс-фактора. Актуальные проблемы биотехнологии и ветеринарной медицины: Материалы Международной научно-практической конференции молодых ученых. Иркутск: Иркутский государственный аграрный университет им. А.А. Ежевского. 2017; 419–429. https://elibrary.ru/xzgikl</mixed-citation><mixed-citation xml:lang="en">Kharlap S.Yu., Loretts O.G., Gorelik O.V., Rebezov M.B., Maksimyuk N.N. Changes in leukocyte indices when assessing the impact of a stress factor. Actual problems of biotechnology and veterinary medicine: Proceedings of the International scientific and practical conference of young scientists. Irkutsk: Irkutsk State Agrarian University named after A.A. Ezhevsky. 2017; 419–429 (in Russian). https://elibrary.ru/xzgikl</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Дроздова Л.И., Кундрюкова У.И. Печень птицы — живая лаборатория оценки качества кормления и содержания. Аграрный вестник Урала. 2010; (5): 68–70. https://elibrary.ru/msxwtz</mixed-citation><mixed-citation xml:lang="en">Drozdova L.I., Kundryukova U.I. Poultry liver — a living laboratory for assessing the quality of feeding and maintenance. Agrarian Bulletin of the Urals. 2010; (5): 68–70 (in Russian). https://elibrary.ru/msxwtz</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Громов И.Н., Сафонов Д.Н., Левкина В.А., Сенченкова А.С. Роль гистологического исследования в диагностике вирусных респираторных и кишечных болезней птиц. Агропромышленный комплекс: проблемы и перспективы развития: Материалы Международной научно-практической конференции. Благовещенск: Дальневосточный государственный аграрный университет, 2024; 10–16. https://doi.org/10.22450/978-5-9642-0629-3-10-16</mixed-citation><mixed-citation xml:lang="en">Gromov I.N., Safonov D.N., Levkina V.A., Senchenkova A.S. The role of histological examination in the diagnosis of avian viral respiratory and intestinal diseases. Agro-industrial complex: problems and development prospects: Proceedings of the International scientific and practical conference. Blagoveshchensk: Far Eastern State Agrarian University. 2024; 10–16 (in Russian). https://doi.org/10.22450/978-5-9642-0629-3-10-16</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Громов И. Роль патоморфологического исследования в диагностике болезней органов пищеварения, обмена веществ и токсикозов птиц. Ветеринарное дело (Минск). 2025; (2): 13–21. https://elibrary.ru/wijbqs.</mixed-citation><mixed-citation xml:lang="en">Gromov I. The role of pathomorphological research in the diagnosis of diseases of the digestive organs, metabolism and toxicosis of birds. Veterinary business (Veterinarnoye delo (Minsk). 2025; (2): 13–21 (in Russian). https://elibrary.ru/wijbqs</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Фисинин В.И., Коноплева А.П. О физиологических и морфологических процессах в организме птицы при естественной и принудительной линьке. Сельскохозяйственная биология. 2015; 50(6): 719–728. https://doi.org/10.15389/agrobiology.2015.6.719rus</mixed-citation><mixed-citation xml:lang="en">Fisinin V.I., Konopleva A.P. About physiological and morphological processes in poultry at natural and induced molting. Agricultural Biology. 2015; 50(6): 719–728 (in Russian). https://doi.org/10.15389/agrobiology.2015.6.719eng</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">He X. et al. Effects of chronic heat exposure on growth performance, intestinal epithelial histology, appetite-related hormones and genes expression in broilers. Journal of the Science of Food and Agriculture. 2018; 98(12): 4471–4478. https://doi.org/10.1002/jsfa.8971</mixed-citation><mixed-citation xml:lang="en">He X. et al. Effects of chronic heat exposure on growth performance, intestinal epithelial histology, appetite-related hormones and genes expression in broilers. Journal of the Science of Food and Agriculture. 2018; 98(12): 4471–4478. https://doi.org/10.1002/jsfa.8971</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Awad W., Ghareeb K., Böhm J. Intestinal Structure and Function of Broiler Chickens on Diets Supplemented with a Synbiotic Containing Enterococcus faecium and Oligosaccharides. International Journal of Molecular Sciences. 2008; 9(11): 2205–2216. https://doi.org/10.3390/ijms9112205</mixed-citation><mixed-citation xml:lang="en">Awad W., Ghareeb K., Böhm J. Intestinal Structure and Function of Broiler Chickens on Diets Supplemented with a Synbiotic Containing Enterococcus faecium and Oligosaccharides. International Journal of Molecular Sciences. 2008; 9(11): 2205–2216. https://doi.org/10.3390/ijms9112205</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Yang P.-C., He S.-H., Zheng P.-Y. Investigation into the signal transduction pathway via which heat stress impairs intestinal epithelial barrier function. Journal of Gastroenterology and Hepatology. 2007; 22(11): 1823–1831. https://doi.org/10.1111/j.1440-1746.2006.04710.x</mixed-citation><mixed-citation xml:lang="en">Yang P.-C., He S.-H., Zheng P.-Y. Investigation into the signal transduction pathway via which heat stress impairs intestinal epithelial barrier function. Journal of Gastroenterology and Hepatology. 2007; 22(11): 1823–1831. https://doi.org/10.1111/j.1440-1746.2006.04710.x</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Abdelqader A., Al-Fataftah A.-R. Thermal acclimation of broiler birds by intermittent heat exposure. Journal of Thermal Biology. 2014; 39: 1–5. https://doi.org/10.1016/j.jtherbio.2013.11.001</mixed-citation><mixed-citation xml:lang="en">Abdelqader A., Al-Fataftah A.-R. Thermal acclimation of broiler birds by intermittent heat exposure. Journal of Thermal Biology. 2014; 39: 1–5. https://doi.org/10.1016/j.jtherbio.2013.11.001</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Mazzoni M., Zampiga M., Clavenzani P., Lattanzio G., Tagliavia C., Sirri F. Effect of chronic heat stress on gastrointestinal histology and expression of feed intake-regulatory hormones in broiler chickens. Animal. 2022; 16(8): 100600. https://doi.org/10.1016/j.animal.2022.100600</mixed-citation><mixed-citation xml:lang="en">Mazzoni M., Zampiga M., Clavenzani P., Lattanzio G., Tagliavia C., Sirri F. Effect of chronic heat stress on gastrointestinal histology and expression of feed intake-regulatory hormones in broiler chickens. Animal. 2022; 16(8): 100600. https://doi.org/10.1016/j.animal.2022.100600</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">He X. et al. Effects of dietary taurine supplementation on growth performance, jejunal morphology, appetite-related hormones, and genes expression in broilers subjected to chronic heat stress. Poultry Science. 2019; 98(7): 2719–2728. https://doi.org/10.3382/ps/pez054</mixed-citation><mixed-citation xml:lang="en">He X. et al. Effects of dietary taurine supplementation on growth performance, jejunal morphology, appetite-related hormones, and genes expression in broilers subjected to chronic heat stress. Poultry Science. 2019; 98(7): 2719–2728. https://doi.org/10.3382/ps/pez054</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Фисинин В.И., Сайфульмулюков Э.Р., Мифтахутдинов А.В. Специализированные фармакологические препараты и кормовые добавки, применяемые в птицеводстве для профилактики технологических стрессов: стрессы различной этиологии. Достижения науки и техники АПК. 2023; 37(11): 75–90. https://elibrary.ru/dwpmzv</mixed-citation><mixed-citation xml:lang="en">Fisinin V.I., Saifulmulyukov E.R., Miftakhutdinov A.V. Specialised pharmacological preparations and feed additives used in poultry farming to prevent technology stress: stress of various aetiologies review). Achievements of science and technology in agribusiness. 2023; 37(11): 75–90 (in Russian). https://elibrary.ru/dwpmzv</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Фисинин В.И., Сайфульмулюков Э.Р., Мифтахутдинов А.В. Специализированные фармакологические препараты и кормовые добавки, применяемые в птицеводстве для профилактики технологических стрессов: тепловой стресс (обзор). Достижения науки и техники АПК. 2023; 37(4): 31–47. https://elibrary.ru/ouvjlk</mixed-citation><mixed-citation xml:lang="en">Fisinin V.I., Saifulmulyukov E.R., Miftakhutdinov A.V. Specialized pharmacological preparations and feed additives used in poultry farming for the prevention of technological stress: heat stress (review). Achievements of science and technology in agribusiness. 2023; 37(4): 31–47 (in Russian). https://elibrary.ru/ouvjlk</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Sahin K., Sahin N., Kucuk O., Hayirli A., Prasad A.S. Role of dietary zinc in heat-stressed poultry: A review. Poultry Science. 2009; 88(10): 2176–2183. https://doi.org/10.3382/ps.2008-00560</mixed-citation><mixed-citation xml:lang="en">Sahin K., Sahin N., Kucuk O., Hayirli A., Prasad A.S. Role of dietary zinc in heat-stressed poultry: A review. Poultry Science. 2009; 88(10): 2176–2183. https://doi.org/10.3382/ps.2008-00560</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Мифтахутдинов А.В., Ноговицина Е.А., Лазарева М.П., Акентьева Е.В. Изучение отдельных адаптационных механизмов и морфологических закономерностей у цыплят-бройлеров на фоне фармакологической профилактики сочетанного предубойного, теплового и транспортного стрессов в промышленном птицеводстве. Российская сельскохозяйственная наука. 2024; (4): 53–60. https://doi.org/10.31857/S2500262724040109</mixed-citation><mixed-citation xml:lang="en">Miftakhutdinov A.V., Nogovitsina E.A., Lazareva M.P., Akentyeva E.V. Study of special adaptation mechanisms and morphological regularities of broiler chickens against the background of pharmacological prevention combined pre-slaughter, heat and transport stress in industrial poultry farming. Russian Agricultural Sciences. 2024; (4): 53–60 (in Russian). https://doi.org/10.31857/S2500262724040109</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Сурай П., Фисинин В.И. Современные методы борьбы со стрессами в птицеводстве: от антиоксидантов к витагенам. Сельскохозяйственная биология. 2012; 47(4): 3–13. https://doi.org/10.15389/agrobiology.2012.4.3rus</mixed-citation><mixed-citation xml:lang="en">Surai P., Fisinin V.I. The modern anti-stress technologies in poultry: from antioxidants to vitagenes. Agricultural Biology. 2012; 47(4): 3–13 (in Russian). https://doi.org/10.15389/agrobiology.2012.4.3eng</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Gilani S., Chrystal P.V., Barekatain R. Current experimental models, assessment and dietary modulations of intestinal permeability in broiler chickens. Animal Nutrition. 2021; 7(3): 801–811. https://doi.org/10.1016/j.aninu.2021.03.001</mixed-citation><mixed-citation xml:lang="en">Gilani S., Chrystal P.V., Barekatain R. Current experimental models, assessment and dietary modulations of intestinal permeability in broiler chickens. Animal Nutrition. 2021; 7(3): 801–811. https://doi.org/10.1016/j.aninu.2021.03.001</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Abdel Aziz A.A.M., Abdel Aziz E.-S.A., Khairy M.H., Fadel C., Giorgi M., Abdelaziz A.S. The effect of butyric acid and nucleotides supplementation on broiler (Gallus gallus domesticus) growth performance, immune status, intestinal histology, and serum parameters. Open Veterinary Journal. 2024; 14(1): 324–334. https://doi.org/10.5455/OVJ.2024.v14.i1.29</mixed-citation><mixed-citation xml:lang="en">Abdel Aziz A.A.M., Abdel Aziz E.-S.A., Khairy M.H., Fadel C., Giorgi M., Abdelaziz A.S. The effect of butyric acid and nucleotides supplementation on broiler (Gallus gallus domesticus) growth performance, immune status, intestinal histology, and serum parameters. Open Veterinary Journal. 2024; 14(1): 324–334. https://doi.org/10.5455/OVJ.2024.v14.i1.29</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Bahrampour H., Mohammadzadeh S., Amiri M. Impact of dietary L-carnitine supplementation on blood parameters and duodenal alterations in laying hens at the end of production. Tissue and Cell. 2024; 91: 102585. https://doi.org/10.1016/j.tice.2024.102585</mixed-citation><mixed-citation xml:lang="en">Bahrampour H., Mohammadzadeh S., Amiri M. Impact of dietary L-carnitine supplementation on blood parameters and duodenal alterations in laying hens at the end of production. Tissue and Cell. 2024; 91: 102585. https://doi.org/10.1016/j.tice.2024.102585</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Yousefi J., Taherpour K., Ghasemi H.A., Akbari Gharaei M., Mohammadi Y., Rostami F. Effects of emulsifier, betaine, and L-carnitine on growth performance, immune response, gut morphology, and nutrient digestibility in broiler chickens exposed to cyclic heat stress. British Poultry Science. 2023; 64(3): 384–397. https://doi.org/10.1080/00071668.2022.2160626</mixed-citation><mixed-citation xml:lang="en">Yousefi J., Taherpour K., Ghasemi H.A., Akbari Gharaei M., Mohammadi Y., Rostami F. Effects of emulsifier, betaine, and L-carnitine on growth performance, immune response, gut morphology, and nutrient digestibility in broiler chickens exposed to cyclic heat stress. British Poultry Science. 2023; 64(3): 384–397. https://doi.org/10.1080/00071668.2022.2160626</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Lien T.-F., Horng Y.-M. The effect of supplementary dietary L-carnitine on the growth performance, serum components, carcase traits and enzyme activities in relation to fatty acid beta-oxidation of broiler chickens. British Poultry Science. 2001; 42(1): 92–95. https://doi.org/10.1080/713655014</mixed-citation><mixed-citation xml:lang="en">Lien T.-F., Horng Y.-M. The effect of supplementary dietary L-carnitine on the growth performance, serum components, carcase traits and enzyme activities in relation to fatty acid beta-oxidation of broiler chickens. British Poultry Science. 2001; 42(1): 92–95. https://doi.org/10.1080/713655014</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Longo N., Frigeni M., Pasquali M. Carnitine transport and fatty acid oxidation. Biochimica et Biophysica Acta (BBA) — Molecular Cell Research. 2016; 1863(10): 2422–2435. https://doi.org/10.1016/j.bbamcr.2016.01.023</mixed-citation><mixed-citation xml:lang="en">Longo N., Frigeni M., Pasquali M. Carnitine transport and fatty acid oxidation. Biochimica et Biophysica Acta (BBA) — Molecular Cell Research. 2016; 1863(10): 2422–2435. https://doi.org/10.1016/j.bbamcr.2016.01.023</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Choi J., Shakeri M., Bowker B., Zhuang H., Kong B. Differentially abundant proteins, metabolites, and lipid molecules in spaghetti meat compared to normal chicken breast meat: Multiomics analysis. Poultry Science. 2025; 104(7): 105165. https://doi.org/10.1016/j.psj.2025.105165</mixed-citation><mixed-citation xml:lang="en">Choi J., Shakeri M., Bowker B., Zhuang H., Kong B. Differentially abundant proteins, metabolites, and lipid molecules in spaghetti meat compared to normal chicken breast meat: Multiomics analysis. Poultry Science. 2025; 104(7): 105165. https://doi.org/10.1016/j.psj.2025.105165</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Fujimoto H., Matsumoto K., Koseki M., Yamashiro H., Yamada T., Takada R. Effects of rice feeding and carnitine addition on growth performance and mRNA expression of protein metabolism-related genes in broiler grower chicks. Animal Science Journal. 2020; 91(1): e13390. https://doi.org/10.1111/asj.13390</mixed-citation><mixed-citation xml:lang="en">Fujimoto H., Matsumoto K., Koseki M., Yamashiro H., Yamada T., Takada R. Effects of rice feeding and carnitine addition on growth performance and mRNA expression of protein metabolism-related genes in broiler grower chicks. Animal Science Journal. 2020; 91(1): e13390. https://doi.org/10.1111/asj.13390</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Pardo Z., Seiquer I. Supplemental Zinc exerts a positive effect against the heat stress damage in intestinal epithelial cells: Assays in a Caco-2 model. Journal of Functional Foods. 2021; 83: 104569. https://doi.org/10.1016/j.jff.2021.104569</mixed-citation><mixed-citation xml:lang="en">Pardo Z., Seiquer I. Supplemental Zinc exerts a positive effect against the heat stress damage in intestinal epithelial cells: Assays in a Caco-2 model. Journal of Functional Foods. 2021; 83: 104569. https://doi.org/10.1016/j.jff.2021.104569</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Сабирзянова Л.И., Лунегов А.М., Коновалова Г.В., Токарь В.В. L-карнитин: применение в животноводстве (обзор литературы). Актуальные вопросы ветеринарной биологии. 2023; (1): 25–31. https://doi.org/10.24412/2074-5036-2023-1-25-31</mixed-citation><mixed-citation xml:lang="en">Sabirzyanova L.I., Lunegov A.M., Konovalova G.V., Tokar V.V. L-carnitine: application in animal husbandry (literature review). Actual questions of veterinary biology. 2023; (1): 25–31 (in Russian). https://doi.org/10.24412/2074-5036-2023-1-25-31</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Остренко К.С., Галочкина В.П., Колоскова Е.М., Галочкин В.А. Органические соли лития — эффективные антистрессовые препараты нового поколения. Проблемы биологии продуктивных животных. 2017; (2): 5–28. https://elibrary.ru/yrtrwz</mixed-citation><mixed-citation xml:lang="en">Ostrenko K.S., Galochkina V.P., Koloskova E.M., Galochkin V.A. Organic lithium salt are effective anti-stress preparations of a new generation. Problems of Productive Animal Biology. 2017; (2): 5–28 (in Russian). https://elibrary.ru/yrtrwz</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
