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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vetpress</journal-id><journal-title-group><journal-title xml:lang="ru">Аграрная наука</journal-title><trans-title-group xml:lang="en"><trans-title>Agrarian science</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-8155</issn><issn pub-type="epub">2686-701X</issn><publisher><publisher-name>Редакция журнала "Аграрная наука"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.32634/0869-8155-2025-401-12-44-49</article-id><article-id custom-type="elpub" pub-id-type="custom">vetpress-3934</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВЕТЕРИНАРИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>VETERINARY MEDICINE</subject></subj-group></article-categories><title-group><article-title>Эффективность применения «Авекардита®» у собак с эндокардиозом митрального клапана при анестезии для санации ротовой полости: сравнительное исследование гемодинамики</article-title><trans-title-group xml:lang="en"><trans-title>Effectiveness of “Avecardit®” use in dogs with mitral valve endocardiosis under anesthesia for oral cavity sanitation: a comparative study of hemodynamics</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-6370-6437</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сметанина</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Smetanina</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елизавета Сергеевна Сметанина, аспирант </p><p>ул. Черниговская, 5, Санкт-Петербург, 196084 </p></bio><bio xml:lang="en"><p>Elizaveta Sergeevna Smetanina, Graduate Student </p><p>5 Chernigovskaya Str., St. Petersburg, 196084 </p></bio><email xlink:type="simple">elizawetasmetanina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2195-6752</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ладанова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ladanova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мария Александровна Ладанова, кандидат ветеринарных наук, доцент</p><p>ул. Черниговская, 5, Санкт-Петербург, 196084  </p></bio><bio xml:lang="en"><p>Maria Alexandrovna Ladanova, Candidate of Veterinary Sciences, Associate Professor</p><p>5 Chernigovskaya Str., St. Petersburg, 196084 </p></bio><email xlink:type="simple">Ldnvmr@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Санкт-Петербургский государственный университет ветеринарной медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg State University of Veterinary Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>13</day><month>12</month><year>2025</year></pub-date><volume>0</volume><issue>12</issue><fpage>44</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сметанина Е.С., Ладанова М.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Сметанина Е.С., Ладанова М.А.</copyright-holder><copyright-holder xml:lang="en">Smetanina E.S., Ladanova M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vetpress.ru/jour/article/view/3934">https://www.vetpress.ru/jour/article/view/3934</self-uri><abstract><p> Эндокардиоз митрального клапана является одним из наиболее распространенных заболеваний сердца у собак и представляет значительный риск при проведении стоматологических операций под общей анестезией. Цель исследования — оценка эффективности применения препарата на основе пимобендана «Авекардит®» при удалении зубов у собак с хронической клапанной регургитацией.</p><p>В исследовании участвовали 40 клинически здоровых собак (с точки зрения других органов) с верифицированным эндокардиозом митрального клапана степени В2. Группа I (n = 20) получала «Авекардит®» в дозе 0,25 мг/кг два раза в день за 7 дней до операции и в течение 7 дней после, группа II (n=20) служила контролем без предоперационной медикаментозной поддержки. Для обезболивания использовались регионарная блокада с бупивакаином. Мониторинг включал электрокардиографию, пульсоксиметрию, неинвазивное измерение артериального давления и регистрацию показателей каждые 5 минут. Результаты исследования показали, что предоперационное применение препаратов на основе пимобендана значительно снижает гемодинамические осложнения и обеспечивает более стабильный ход анестезии. Собаки группы I демонстрировали лучшую гемодинамическую стабильность с меньшей степенью снижения артериального давления (14,2% в группе I против 31,8% в группе II). Осложнений, связанных с кардиотоксичностью местных анестетиков, не зарегистрировано.</p><p>Разработанный анестезиологический протокол может быть рекомендован для использования при стоматологических операциях у собак с эндокардиозом митрального клапана. </p></abstract><trans-abstract xml:lang="en"><p>Mitral valve endocardiosis is one of the most common heart diseases in dogs and poses a significant risk during dental surgery under general anesthesia.</p><p>The aim of the study was to evaluate the effectiveness of the pimobendan-based drug “Avecardit®” in tooth extraction in dogs with chronic valvular regurgitation. valve regurgitation. The study involved 40 clinically healthy dogs (from the point of view of other organs) with verified grade B2 mitral valve endocardiosis. Group I (n = 20) received “Avecarditis®” at a dose of 0.25 mg/kg twice daily 7 days before surgery and for 7 days after, group II (n = 20) served as a control without preoperative drug support.</p><p>Regional blockade with bupivacaine was used for anesthesia. Monitoring included electrocardiography, pulse oximetry, noninvasive blood pressure measurement, and recording of readings every 5 minutes.</p><p>The results of the study showed that the preoperative use of pimobendan-based drugs significantly reduces hemodynamic complications and ensures a more stable course of anesthesia. The dogs of group I demonstrated better hemodynamic stability with a lower degree of reduction in blood pressure (14.2% in group I versus 31.8% in group II). No complications related to the cardiotoxicity of local anesthetics have been reported.</p><p>The developed anesthetic protocol can be recommended for use in dental operations in dogs with mitral valve endocardiosis. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>эндокардиоз</kwd><kwd>пимобендан</kwd><kwd>«Авекардит®»</kwd><kwd>санация ротовой полости</kwd><kwd>анестезиология</kwd><kwd>стоматология</kwd><kwd>собаки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>endocardiosis</kwd><kwd>pimobendane</kwd><kwd>avecardit®</kwd><kwd>dental prophylasis</kwd><kwd>anestesiology</kwd><kwd>dentistry</kwd><kwd>dog</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Keene B.W. et al. ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs. 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