vetpressАграрная наукаAgrarian science0869-81552686-701XРедакция журнала "Аграрная наука"10.32634/0869-8155-2026-405-04-45-54vetpress-4113Research ArticleЗООТЕХНИЯZOOTECHNICSВлияние кормовой добавки на основе биомассы дрожжей Rhodosporidium diobovatum на яичную продуктивность перепеловA feed additive based on the yeast biomass of Rhodosporidium diobovatum for egg production in quailshttps://orcid.org/0000-0002-3679-9155КасановаН. Р.KasanovaN. R.

Надия Радиковна Касанова, кандидат сельскохозяйственных наук, доцент кафедры биологии, генетики, общей и биологической химии 

ул. Карла Маркса, 65, Казань, 420015

Nadiya Radikovna Kasanova, Candidate of Agriculture Sciences, Associate Professor of Biology, Genetics, General and Biological Chemistry 

65 Karl Marx st., Kazan, 420015

nadia-kasanova@mail.ruhttps://orcid.org/0000-0003-3539-4065ГайнуллинаМ. К.GainullinaM. K.

Мунира Кабировна Гайнуллина, доктор сельскохозяйственных наук, профессор, заведующая кафедрой технологии производства и переработки сельскохозяйственной продукции

ул. Карла Маркса, 65, Казань, 420015

Munira Kabirovna Gainullina, Doctor of Agricultural Sciences, Professor, Head of the Department of Technology of Production and Processing of agricultural Products

65 Karl Marx st., Kazan, 420015

gainullinamun@yandex.ruПросвирниковД. Б.ProsvirnikovD. B.

Дмитрий Богданович Просвирников, доктор технических наук, профессор кафедры химической кибернетики

ул. Карла Маркса, д. 68, Казань, 420015

Dmitry Bogdanovich Prosvirnikov, Doctor of Technical Sciences, Professor of the Department of Chemical Cybernetics

68 Karl Marx st., Kazan, 420015

prosvirnikov_dmi@mail.ruhttps://orcid.org/0000-0003-1842-5771ТунцевД. В.TuntsevD. V.

Денис Владимирович Тунцев, доктор технических наук, профессор,заведующий кафедрой химической кибернетики, ведущий научный сотрудник

ул. Карла Маркса, д. 68, Казань, 420015

Denis Vladimirovich Tuntsev, Doctor of Technical Sciences, Professor,Head of the Department of Chemical Cybernetics, Leading Researcher

68 Karl Marx st., Kazan, 420015

tuncev_d@mail.ruhttps://orcid.org/0000-0002-8086-1788КрупинЕ. О.KrupinE. O.

Евгений Олегович Крупин, доктор ветеринарных наук, ведущий научный сотрудник отдела физиологии, биохимии, генетики и питания животных 

Оренбургский тракт, д. 48, Казань, 420059

Evgeny Olegovich Krupin, Doctor of Veterinary Sciences, Leading Researcher of the Department of Physiology, Biochemistry, Genetics and Animal Nutrition

48 Orenburgsky Trakt, Kazan, 420059

evgeny.krupin@gmail.comhttps://orcid.org/0000-0001-6054-5764СаляховА. Ш.SalakhovA. S.

Алмаз Шамилевич Саляхов, кандидат сельскохозяйственных наук, доцент кафедры технологии производства и переработки сельхозпродукции

ул. Карла Маркса, 65, Казань, 420015

Almaz Shamilevich Salakhov, Candidate of Agricultural Sciences, Associate Professor of the Department of Technology of Production and Processing of agricultural Products

65 Karl Marx st., Kazan, 420015

almaz61sh@mail.ruhttps://orcid.org/0000-0002-8040-6750ЯкимовО. А.YakimovO. A.

Олег Алексеевич Якимов, доктор биологических наук, профессор кафедры технологии производства и переработки сельхозпродукции

ул. Карла Маркса, 65, Казань, 420015

Oleg Alekseevich Yakimov, Doctor of Biological Sciences, Professor of the Department of Technology of Production and Processing of agricultural Products

65 Karl Marx st., Kazan, 420015

nikita.korolev.1984@mail.ruhttps://orcid.org/0009-0007-5608-576XГоловковаЕ. Е.GolovkovaE. E.

Екатерина Евгеньевна Головкова, студент

ул. Карла Маркса, 65, Казань, 420015

Ekaterina Evgenievna Golovkova, student

65 Karl Marx st., Kazan, 420015

kate.miller.26@bk.ruКазанский государственный аграрный университетРоссияKazan State Agrarian UniversityRussian FederationКазанский национальный исследовательский технологический университетРоссияKazan National Research Technological UniversityRussian FederationКазанский государственный аграрный университетРоссияTatar Research Institute of Agriculture is a separate structural subdivision of the Federal State Budgetary Scientific Institution “Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”Russian FederationТатарский научно-исследовательский институт сельского хозяйства — обособленное структурное подразделение ФГБНУ «Федеральный исследовательский центр «Казанский научный центр Российской академии наук»РоссияKazan State Agrarian UniversityRussian Federation202621042026044554Copyright © Касанова Н.Р., Гайнуллина М.К., Просвирников Д.Б., Тунцев Д.В., Крупин Е.О., Саляхов А.Ш., Якимов О.А., Головкова Е.Е., 20262026Касанова Н.Р., Гайнуллина М.К., Просвирников Д.Б., Тунцев Д.В., Крупин Е.О., Саляхов А.Ш., Якимов О.А., Головкова Е.Е.Kasanova N.R., Gainullina M.K., Prosvirnikov D.B., Tuntsev D.V., Krupin E.O., Salakhov A.S., Yakimov O.A., Golovkova E.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vetpress.ru/jour/article/view/4113Актуальность

Актуальность. Большое влияние на продуктивность сельскохозяйственной птицы оказывает обеспеченность высококачественным протеиновыми кормами и биологически активными веществами. Высокая биологическая активность каротиноидов вызывает интерес и обуславливает поиск эффективных способов их получения и применения. Экспериментальные данные о применении астаксантина в питании теплокровных животных ограничены.

Методы

Методы. В рационы перепелов 2, 3 и 4 групп дополнительно вводили кормовую добавку, полученную путем культивирования дрожжей Rodosporidium diobovatum, из расчета 0,4; 0,8 и 1,2 г/кг живой массы соответственно. Отбор проб комбикорма проводили по ГОСТ 13496.0-2016, отбор проб и оценку качества полученных яиц — по ГОСТ 31655-2012. Химический анализ яиц включал определение сухого вещества, сырого протеина, сырого жира, сырой золы, кальция, фосфора с предварительной пробоподготовкой. Оценку яичной продуктивности проводили с начала яйцекладки. Определяли массу яиц, белка, желтка, индексы формы яиц, белка, желтка, единицу ХАУ по общепринятым методикам, содержание каротиноидов в яичном желтке — по ГОСТ Р 54058-2010.

Результаты

Результаты. Скармливание перепелам-несушкам кормовой добавки, полученной путем культивирования дрожжей Rhodosporidium diobovatum, способствовало повышению яйценоскости на 28,9%, 13,9% и 4,8%, интенсивности яйценоскости на 20,8%, 10,0% и 3,5%, улучшению морфологических показателей, инкубационных качеств и пищевой ценности перепелиных яиц, а также содержанию каротиноидов в желтке на 36,4%, 30,9% и 3,6% соответственно. Наилучшие показатели яичной продуктивности были получены у птицы 2 и 3 групп.

Relevance

Relevance. The availability of high-quality protein feed and biologically active substances has a significant impact on the productivity of poultry. The high biological activity of carotenoids is of interest and leads to the search for effective ways to obtain and use them. Experimental data on the use of astaxanthin in the diet of warm-blooded animals are limited.

Methods

Methods. A feed additive obtained by cultivating the yeast Rodosporidium diobovatum was additionally introduced into the diets of quails in groups 2, 3 and 4 at the rate of 0,4; 0,8 and 1,2 g/kg of live weight, respectively. Sampling of compound feed was carried out in accordance with GOST 13496.0-2016, sampling and quality assessment of the obtained eggs — in accordance with GOST 31655-2012. The chemical analysis of eggs included the determination of dry matter, crude protein, crude fat, crude ash, calcium, phosphorus with preliminary sample preparation. Egg productivity was assessed from the beginning of oviposition. The weight of eggs, protein, yolk, the shape indices of eggs, protein, yolk, and the HAU unit were determined using generally accepted methods, and the content of carotenoids in egg yolk was determined according to GOST R 54058-2010.

Results

Results. Feeding protein-vitamin feed additives to laying quails obtained by cultivating Rhodosporidium diobovatum yeast increased egg production by 28.9%, 13.9% and 4.8%, egg production intensity by 20.8%, 10.0% and 3.5%, improved morphological parameters, incubation qualities and nutritional value of quail eggs, as well as the carotenoid content in the yolk by 36.4%, 30.9% and 3.6%, respectively. The best egg production rates were obtained in birds of groups 2 and 3.

дрожжибелоккаротиноидыастаксантинперепелаяичная продуктивностьяйцакачествоyeastproteincarotenoidsastaxanthinquailegg productioneggsqualityРабота выполнена за счет предоставленного в 2025 году Фондом науки и технологий Республики Татарстан гранта на осуществление фундаментальных и поисковых исследований в научных и образовательных организациях, предприятиях и организациях реального сектора экономики Республики Татарстан (соглашение №2 от 01.12.2025 г).The research was carried out at the expense of a grant provided in 2025 by the Foundation for Science and Technology of the Republic of Tatarstan for the implementation of fundamental and exploratory research in scientific and educational organizations, enterprises and organizations of the real sector of the economy of the Republic of Tatarstan (agreement No. 2 dated 01.12.2025)ReferencesАндрианова Е.Н. Егоров И.А., Григорьева Е.Н., Шевяков А.Н., Пронин В.В. Люпин в кормлении кур-несушек родительского стада. Сельскохозяйственная биология. 2019; 54(2): 326–336. https://doi.org/10.15389/agrobiology.2019.2.326rusAndrianova E.N. Egorov I.A., Grigoryeva E.N., Shevyakov A.N., Pronin V.V. Lupine is applicable in diets for layer chicken of parental flock. Agricultural Biology. 2019; 54(2): 326–336 (in Russian). https://doi.org/10.15389/agrobiology.2019.2.326engВолкова С.В., Белокурова Е.С., Рубанов Д.А. Дрожжи рода Rhodotorula — перспективный источник каротиноидов для кормопроизводства. Пищевая индустрия в современных условиях: тренды и инновации. Сборник научных статей Международной научно-практической конференции. Орел: ОрелГАУ. 2023; 2: 298–302. EDN FSTSFXVolkova S.V., Belokurova E.S., Rubanov D.A. Genus Rhodotorula is a promising source of carotenoids for forage production. The food industry in modern conditions: trends and innovations. Collection of scientific articles of the International scientific and practical conference. Orel: Orel State Agrarian University. 2023; 2: 298–302 (in Russian). EDN FSTSFXМифтахутдинов А.В., Дихтярук И.Н. Влияние антистрессового фармакологического комплекса «СПАО» на эффективность профилактической иммунизации кур против болезни Ньюкасла. Аграрная наука. 2020; (3): 13–16. https://doi.org/10.32634/0869-8155-2020-336-3-13-16Miftakhutdinov A.V., Dikhtyaruk I.N. The influence of the anti-stress pharmacological complex “SPAO” on the effectiveness of preventive immunization of chickens against Newcastle disease. Agrarian science. 2020; (3): 13–16 (in Russian). https://doi.org/10.32634/0869-8155-2020-336-3-13-16Pagels F., Vasconcelos V., Guedes A.C. Carotenoids from Cyanobacteria: Biotechnological Potential and Optimization Strategies. Biomolecules. 2021; 11(5): 735. https://doi.org/10.3390/biom11050735Pagels F., Vasconcelos V., Guedes A.C. Carotenoids from Cyanobacteria: Biotechnological Potential and Optimization Strategies. Biomolecules. 2021; 11(5): 735. https://doi.org/10.3390/biom11050735Maoka T. Carotenoids as natural functional pigments. Journal of Natural Medicines. 2020; 74(1): 1–16. https://doi.org/10.1007/s11418-019-01364-xMaoka T. Carotenoids as natural functional pigments. Journal of Natural Medicines. 2020; 74(1): 1–16. https://doi.org/10.1007/s11418-019-01364-xAshokkumar V. et al. Technological advances in the production of carotenoids and their applications — A critical review. Bioresource Technology. 2023; 367: 128215. https://doi.org/10.1016/j.biortech.2022.128215Ashokkumar V. et al. Technological advances in the production of carotenoids and their applications — A critical review. Bioresource Technology. 2023; 367: 128215. https://doi.org/10.1016/j.biortech.2022.128215Foong L.C., Loh C.W.L., Ng H.S., Lan J.C.-W. Recent development in the production strategies of microbial carotenoids. World Journal of Microbiology and Biotechnology. 2021; 37(1): 12. https://doi.org/10.1007/s11274-020-02967-3Foong L.C., Loh C.W.L., Ng H.S., Lan J.C.-W. Recent development in the production strategies of microbial carotenoids. World Journal of Microbiology and Biotechnology. 2021; 37(1): 12. https://doi.org/10.1007/s11274-020-02967-3Novoveská L., Ross M.E., Stanley M.S., Pradelles R., Wasiolek V., Sassi J.-F. Microalgal Carotenoids: A Review of Production, Current Markets, Regulations, and Future Direction. Marine Drugs. 2019; 17(11): 640. https://doi.org/10.3390/md17110640Novoveská L., Ross M.E., Stanley M.S., Pradelles R., Wasiolek V., Sassi J.-F. Microalgal Carotenoids: A Review of Production, Current Markets, Regulations, and Future Direction. Marine Drugs. 2019; 17(11): 640. https://doi.org/10.3390/md17110640Bhosale P., Jogdand V.V., Gadre R.V. Stability of β-carotene in spray dried preparation of Rhodotorula glutinis mutant 32. Journal of Applied Microbiology. 2003; 95(3): 584–590. https://doi.org/10.1046/j.1365-2672.2003.02018.xBhosale P., Jogdand V.V., Gadre R.V. Stability of β-carotene in spray dried preparation of Rhodotorula glutinis mutant 32. Journal of Applied Microbiology. 2003; 95(3): 584–590. https://doi.org/10.1046/j.1365-2672.2003.02018.xКолпакова В.В. и др. Использование экологически безопасного микромицета рода Rhodotorula для получения кормового каротинсодержащего концентрата. Юг России: экология, развитие. 2022; 17(4): 61–78. https://doi.org/10.18470/1992-1098-2022-4-61-78Kolpakova V.V. et al. Use of environmentally safe micromycetes of the genus Rhodotorula to obtain fodder carotene‐containing concentrate. South of Russia: ecology, development. 2022; 17(4): 61–78 (in Russian). https://doi.org/10.18470/1992-1098-2022-4-61-78Shashikala K.B., Hemalatha B.N., Pooja S., Patil S.J. Nutraceutical Antioxidants and Their Influence on Reproduction. Keservani R.K., Patil S.J., Aranha I. (eds.). Nutraceuticals for the Treatment and Prevention of Sexual Disorders. Apple Academic Press. 2025; 399 421. https://doi.org/10.1201/9781003503774-21Shashikala K.B., Hemalatha B.N., Pooja S., Patil S.J. Nutraceutical Antioxidants and Their Influence on Reproduction. Keservani R.K., Patil S.J., Aranha I. (eds.). Nutraceuticals for the Treatment and Prevention of Sexual Disorders. Apple Academic Press. 2025; 399 421. https://doi.org/10.1201/9781003503774-21Surai P.F., Speake B.K., Sparks N.H.C. Carotenoids in Avian Nutrition and Embryonic Development. 1. Absorption, Availability and Levels in Plasma and Egg Yolk. The Journal of Poultry Science. 2001; 38(1): 1–27. https://doi.org/10.2141/jpsa.38.1Surai P.F., Speake B.K., Sparks N.H.C. Carotenoids in Avian Nutrition and Embryonic Development. 1. Absorption, Availability and Levels in Plasma and Egg Yolk. The Journal of Poultry Science. 2001; 38(1): 1–27. https://doi.org/10.2141/jpsa.38.1Surai P.F., Speake B.K., Sparks N.H.C. Carotenoids in Avian Nutrition and Embryonic Development. 2. Antioxidant Properties and Discrimination in Embryonic Tissues. The Journal of Poultry Science. 2001; 38(2): 117–145. https://doi.org/10.2141/jpsa.38.117Surai P.F., Speake B.K., Sparks N.H.C. Carotenoids in Avian Nutrition and Embryonic Development. 2. Antioxidant Properties and Discrimination in Embryonic Tissues. The Journal of Poultry Science. 2001; 38(2): 117–145. https://doi.org/10.2141/jpsa.38.117Surai P.F., Bortolotti G.R., Fidgett A.L., Blount J.D., Speake B.K. Effects of piscivory on the fatty acid profiles and antioxidants of avian yolk: studies on eggs of the gannet, skua, pelican and cormorant. Journal of Zoology. 2001; 255(3): 305–312. https://doi.org/10.1017/S0952836901001406Surai P.F., Bortolotti G.R., Fidgett A.L., Blount J.D., Speake B.K. Effects of piscivory on the fatty acid profiles and antioxidants of avian yolk: studies on eggs of the gannet, skua, pelican and cormorant. Journal of Zoology. 2001; 255(3): 305–312. https://doi.org/10.1017/S0952836901001406Garamszegi L.Z., Biard C., Eens M., Møller A.P., Saino N., Surai P. Maternal effects and the evolution of brain size in birds: Overlooked developmental constraints. Neuroscience & Biobehavioral Reviews. 2007; 31(4): 498–515. https://doi.org/10.1016/j.neubiorev.2006.11.008Garamszegi L.Z., Biard C., Eens M., Møller A.P., Saino N., Surai P. Maternal effects and the evolution of brain size in birds: Overlooked developmental constraints. Neuroscience & Biobehavioral Reviews. 2007; 31(4): 498–515. https://doi.org/10.1016/j.neubiorev.2006.11.008Surai P.F. Natural Antioxidants in Avian Nutrition and Reproduction. Nottingham: Nottingham University Press. 2002; xvi, 615. ISBN 1-897676-95-6Surai P.F. Natural Antioxidants in Avian Nutrition and Reproduction. Nottingham: Nottingham University Press. 2002; xvi, 615. ISBN 1-897676-95-6Nair A. et al. Astaxanthin as a King of Ketocarotenoids: Structure, Synthesis, Accumulation, Bioavailability and Antioxidant Properties. Marine Drugs. 2023; 21(3): 176. https://doi.org/10.3390/md21030176Nair A. et al. Astaxanthin as a King of Ketocarotenoids: Structure, Synthesis, Accumulation, Bioavailability and Antioxidant Properties. Marine Drugs. 2023; 21(3): 176. https://doi.org/10.3390/md21030176Колдаев В.М., Кропотов А.В. Каротиноиды в практической медицине. Тихоокеанский медицинский журнал. 2022; (1): 65–71. https://doi.org/10.34215/1609-1175-2022-1-65-71Koldaev V.M., Kropotov A.V. Carotenoids in practical medicine. Pacific Medical Journal. 2022; (1): 65–71 (in Russian). https://doi.org/10.34215/1609-1175-2022-1-65-71Møller A.P. et al. Carotenoid-dependent Signals: Indicators of Foraging Efficiency, Immunocompetence or Detoxification Ability?. Avian and Poultry Biology Reviews. 2000; 11(3): 137–159.Møller A.P. et al. Carotenoid-dependent Signals: Indicators of Foraging Efficiency, Immunocompetence or Detoxification Ability?. Avian and Poultry Biology Reviews. 2000; 11(3): 137–159.Blount J.D., Metcalfe N.B., Birkhead T.R., Surai P.F. Carotenoid Modulation of Immune Function and Sexual Attractiveness in Zebra Finches. Science. 2003; 300(5616): 125–127. https://doi.org/10.1126/science.1082142Blount J.D., Metcalfe N.B., Birkhead T.R., Surai P.F. Carotenoid Modulation of Immune Function and Sexual Attractiveness in Zebra Finches. Science. 2003; 300(5616): 125–127. https://doi.org/10.1126/science.1082142Reboul E. Mechanisms of Carotenoid Intestinal Absorption: Where Do We Stand?. Nutrients. 2019; 11(4): 838. https://doi.org/10.3390/nu11040838Reboul E. Mechanisms of Carotenoid Intestinal Absorption: Where Do We Stand?. Nutrients. 2019; 11(4): 838. https://doi.org/10.3390/nu11040838Phelan D., Prado-Cabrero A., Nolan J.M. Analysis of Lutein, Zeaxanthin, and Meso-Zeaxanthin in the Organs of Carotenoid Supplemented Chickens. Foods. 2018; 7(2): 20. https://doi.org/10.3390/foods7020020Phelan D., Prado-Cabrero A., Nolan J.M. Analysis of Lutein, Zeaxanthin, and Meso-Zeaxanthin in the Organs of Carotenoid Supplemented Chickens. Foods. 2018; 7(2): 20. https://doi.org/10.3390/foods7020020Ren T., Xu M., Lin W., Luo W., Zhang X. Transcriptome sequencing reveals the potential mechanisms of dietary lutein regulation on chicken leg muscle development. Poultry Science. 2024; 103(12): 104265. https://doi.org/10.1016/j.psj.2024.104265Ren T., Xu M., Lin W., Luo W., Zhang X. Transcriptome sequencing reveals the potential mechanisms of dietary lutein regulation on chicken leg muscle development. Poultry Science. 2024; 103(12): 104265. https://doi.org/10.1016/j.psj.2024.104265Liao Y. et al. Metabolism, Function, Molecular Mechanism, and Application of Carotenoids in Coloration of Aquatic Animals. Reviews in Aquaculture. 2025; 17(2): e70016. https://doi.org/10.1111/raq.70016Liao Y. et al. Metabolism, Function, Molecular Mechanism, and Application of Carotenoids in Coloration of Aquatic Animals. Reviews in Aquaculture. 2025; 17(2): e70016. https://doi.org/10.1111/raq.70016Николаевич Л.Н., Згировская А.А., Борисовец Д.С. Биологические свойства каротиноидов и их применение в рационе питания сельскохозяйственных животных (обзор). Эпизоотология, иммунобиология, фармакология, санитария. 2023; (1): 53–59. EDN NFJGKONikolaevich L.N., Zgirovskaya A.A., Borisovets D.S. Biological properties of carotenoids and their application in the diet of farm animals (review). Epizootology, Immunobiology, Pharmacology, Sanitation. 2023; (1): 53–59 (in Russian). EDN NFJGKOChang J.-H., Chen Y., Holland D., Grabowski J. Estimating spatial distribution of American lobster Homarus americanus using habitat variables. Marine Ecology Progress Series. 2010; 420: 145–156. https://doi.org/10.3354/meps08849Chang J.-H., Chen Y., Holland D., Grabowski J. Estimating spatial distribution of American lobster Homarus americanus using habitat variables. Marine Ecology Progress Series. 2010; 420: 145–156. https://doi.org/10.3354/meps08849Ambati R.R., Phang S.-M., Ravi S., Aswathanarayana R.G. Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review. Marine Drugs. 2014; 12(1): 128–152. https://doi.org/10.3390/md12010128Ambati R.R., Phang S.-M., Ravi S., Aswathanarayana R.G. Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review. Marine Drugs. 2014; 12(1): 128–152. https://doi.org/10.3390/md12010128European Food Safety Authority (EFSA). Opinion of the Scientific Panel on additives and products or substances used in animal feed (FEEDAP) on the safety of use of colouring agents in animal nutrition — PART I. General Principles and Astaxanthin. EFSA Journal. 2005; 3(12): 291. https://doi.org/10.2903/j.efsa.2005.291European Food Safety Authority (EFSA). Opinion of the Scientific Panel on additives and products or substances used in animal feed (FEEDAP) on the safety of use of colouring agents in animal nutrition — PART I. General Principles and Astaxanthin. EFSA Journal. 2005; 3(12): 291. https://doi.org/10.2903/j.efsa.2005.291Rizzardi N. et al. Natural Astaxanthin Is a Green Antioxidant Able to Counteract Lipid Peroxidation and Ferroptotic Cell Death. International Journal of Molecular Sciences. 2022; 23(23): 15137. https://doi.org/10.3390/ijms232315137Rizzardi N. et al. Natural Astaxanthin Is a Green Antioxidant Able to Counteract Lipid Peroxidation and Ferroptotic Cell Death. International Journal of Molecular Sciences. 2022; 23(23): 15137. https://doi.org/10.3390/ijms232315137Edge R., Gaikwad P., Navaratnam S., Rao B.S.M., Truscott G.T. Reduction of oxidized guanosine by dietary carotenoids: A pulse radiolysis study. Archives of Biochemistry and Biophysics. 2010; 504(1): 100–103. https://doi.org/10.1016/j.abb.2010.07.026Edge R., Gaikwad P., Navaratnam S., Rao B.S.M., Truscott G.T. Reduction of oxidized guanosine by dietary carotenoids: A pulse radiolysis study. Archives of Biochemistry and Biophysics. 2010; 504(1): 100–103. https://doi.org/10.1016/j.abb.2010.07.026Abdol Wahab N.R., Meor Mohd Affandi M.M.R., Fakurazi S., Alias E., Hassan H. Nanocarrier System: State-of-the-Art in Oral Delivery of Astaxanthin. Antioxidants. 2022; 11(9): 1676. https://doi.org/10.3390/antiox11091676Abdol Wahab N.R., Meor Mohd Affandi M.M.R., Fakurazi S., Alias E., Hassan H. Nanocarrier System: State-of-the-Art in Oral Delivery of Astaxanthin. Antioxidants. 2022; 11(9): 1676. https://doi.org/10.3390/antiox11091676Ciaraldi T.P., Boeder S.C., Mudaliar S.R., Giovannetti E.R., Henry R.R., Pettus J.H. Astaxanthin, a natural antioxidant, lowers cholesterol and markers of cardiovascular risk in individuals with prediabetes and dyslipidaemia. Diabetes, Obesity and Metabolism. 2023; 25(7): 1985–1994. https://doi.org/10.1111/dom.15070Ciaraldi T.P., Boeder S.C., Mudaliar S.R., Giovannetti E.R., Henry R.R., Pettus J.H. Astaxanthin, a natural antioxidant, lowers cholesterol and markers of cardiovascular risk in individuals with prediabetes and dyslipidaemia. Diabetes, Obesity and Metabolism. 2023; 25(7): 1985–1994. https://doi.org/10.1111/dom.15070Eldessouki E.A.A. et al. Influence of astaxanthin-enriched Haematococcus pluvialis microalgae on the growth efficacy, immune response, antioxidant capacity, proinflammatory cytokines, and tissue histomorphology of hybrid red tilapia. Aquaculture International. 2024; 32(6): 7447–7468. https://doi.org/10.1007/s10499-024-01524-1Eldessouki E.A.A. et al. Influence of astaxanthin-enriched Haematococcus pluvialis microalgae on the growth efficacy, immune response, antioxidant capacity, proinflammatory cytokines, and tissue histomorphology of hybrid red tilapia. Aquaculture International. 2024; 32(6): 7447–7468. https://doi.org/10.1007/s10499-024-01524-1Nakagawa K. et al. Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes. British Journal of Nutrition. 2011; 105(11): 1563–1571. https://doi.org/10.1017/S0007114510005398Nakagawa K. et al. Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes. British Journal of Nutrition. 2011; 105(11): 1563–1571. https://doi.org/10.1017/S0007114510005398Остапчук П.С., Зубоченко Д.В., Куевда Т.А. Роль антиоксидантов и использование их в животноводстве и птицеводстве (обзор). Аграрная наука Евро-Северо-Востока. 2019; 20(2): 103–117. https://doi.org/10.30766/2072-9081.2019.20.2.103-117Ostapchuk P.S., Zubochenko D.V., Kuevda T.A. The role of antioxidants and their use in animal breeding and poultry farming (review). Agricultural Science Euro-North-East. 2019; 20(2): 103–117 (in Russian). https://doi.org/10.30766/2072-9081.2019.20.2.103-117Довыденкова М.В., Колодина Е.Н., Никанова Д.А., Логвинова Т.И., Артемьева О.А. Эффективность использования каротинсинтезирующих дрожжей Rhodotorula spp. в кормлении сельскохозяйственных животных. Животноводство и кормопроизводство. 2024; 107(2): 149–169. https://doi.org/10.33284/2658-3135-107-2-149Dovydenkova M.V., Kolodina E.N., Nikanova D.A., Logvinova T.I., Artemieva O.A. The effectiveness of using carotene-synthesizing yeast Rhodotorula spp. in feeding farm animals (review). Animal Husbandry and Fodder Production. 2024; 107(2): 149–169 (in Russian). https://doi.org/10.33284/2658-3135-107-2-149El-Banna A., El-Razek A., El-Mahdy A. Some Factors Affecting the Production of Carotenoids by Rhodotorula glutinis var. Glutinis. Food and Nutrition Sciences. 2012; 3(1): 64–71. https://doi.org/10.4236/fns.2012.31011El-Banna A., El-Razek A., El-Mahdy A. Some Factors Affecting the Production of Carotenoids by Rhodotorula glutinis var. Glutinis. Food and Nutrition Sciences. 2012; 3(1): 64–71. https://doi.org/10.4236/fns.2012.31011Ge Y., Huang K., Xie W., Xu C., Yao Q., Liu Y. Effects of Rhodotorula mucilaginosa on the Immune Function and Gut Microbiota of Mice. Frontiers in Fungal Biology. 2021; 2: 705696. https://doi.org/10.3389/ffunb.2021.705696Ge Y., Huang K., Xie W., Xu C., Yao Q., Liu Y. Effects of Rhodotorula mucilaginosa on the Immune Function and Gut Microbiota of Mice. Frontiers in Fungal Biology. 2021; 2: 705696. https://doi.org/10.3389/ffunb.2021.705696Elwan H.A.M., Elnesr S.S., Abdallah Y., Hamdy A., El-Bogdady A.H. Red yeast (Phaffia rhodozyma) as a source of Astaxanthin and its impacts on productive performance and physiological responses of poultry. World’s Poultry Science Journal. 2019; 75(2): 273–284. https://doi.org/10.1017/S0043933919000187Elwan H.A.M., Elnesr S.S., Abdallah Y., Hamdy A., El-Bogdady A.H. Red yeast (Phaffia rhodozyma) as a source of Astaxanthin and its impacts on productive performance and physiological responses of poultry. World’s Poultry Science Journal. 2019; 75(2): 273–284. https://doi.org/10.1017/S0043933919000187Wang L., Xie J., Wu W., Li B., Ou J. Excellent microbial cultivation for astaxanthin production and its extraction by Rhodotorula benthica. Med. Res. 2018; 2(4): 180015. https://doi.org/10.21127/yaoyimr20180015Wang L., Xie J., Wu W., Li B., Ou J. Excellent microbial cultivation for astaxanthin production and its extraction by Rhodotorula benthica. Med. Res. 2018; 2(4): 180015. https://doi.org/10.21127/yaoyimr20180015Dávila-Ramírez J.L. et al. Effect of yeast culture (Saccharomyces cerevisiae) supplementation on growth performance, blood metabolites, carcass traits, quality, and sensorial traits of meat from pigs under heat stress. Animal Feed Science and Technology. 2020; 267: 114573. https://doi.org/10.1016/j.anifeedsci.2020.114573Dávila-Ramírez J.L. et al. Effect of yeast culture (Saccharomyces cerevisiae) supplementation on growth performance, blood metabolites, carcass traits, quality, and sensorial traits of meat from pigs under heat stress. Animal Feed Science and Technology. 2020; 267: 114573. https://doi.org/10.1016/j.anifeedsci.2020.114573Haddad S.G., Goussous S.N. Effect of yeast culture supplementation on nutrient intake, digestibility and growth performance of Awassi lambs. Animal Feed Science and Technology. 2005; 118(3–4): 343–348. https://doi.org/10.1016/j.anifeedsci.2004.10.003Haddad S.G., Goussous S.N. Effect of yeast culture supplementation on nutrient intake, digestibility and growth performance of Awassi lambs. Animal Feed Science and Technology. 2005; 118(3–4): 343–348. https://doi.org/10.1016/j.anifeedsci.2004.10.003Lei Y., Kim I.H. Effect of Phaffia rhodozyma on performance, nutrient digestibility, blood characteristics, and meat quality in finishing pigs. Journal of Animal Science. 2014; 92(1): 171–176. https://doi.org/10.2527/jas.2013-6749Lei Y., Kim I.H. Effect of Phaffia rhodozyma on performance, nutrient digestibility, blood characteristics, and meat quality in finishing pigs. Journal of Animal Science. 2014; 92(1): 171–176. https://doi.org/10.2527/jas.2013-6749Song B. et al. Dietary Supplementation of Yeast Culture Into Pelleted Total Mixed Rations Improves the Growth Performance of Fattening Lambs. Frontiers in Veterinary Science. 2021; 8: 657816. https://doi.org/10.3389/fvets.2021.657816Song B. et al. Dietary Supplementation of Yeast Culture Into Pelleted Total Mixed Rations Improves the Growth Performance of Fattening Lambs. Frontiers in Veterinary Science. 2021; 8: 657816. https://doi.org/10.3389/fvets.2021.657816Ayiku S., Shen J.-f., Tan B.-p., Dong X.-h., Liu H.-y. Effects of dietary yeast culture on shrimp growth, immune response, intestinal health and disease resistance against Vibrio harveyi. Fish & Shellfish Immunology. 2020; 102: 286–295. https://doi.org/10.1016/j.fsi.2020.04.036Ayiku S., Shen J.-f., Tan B.-p., Dong X.-h., Liu H.-y. Effects of dietary yeast culture on shrimp growth, immune response, intestinal health and disease resistance against Vibrio harveyi. Fish & Shellfish Immunology. 2020; 102: 286–295. https://doi.org/10.1016/j.fsi.2020.04.036Srinual O. et al. Can Red Yeast (Sporidiobolus pararoseus) Be Used as a Novel Feed Additive for Mycotoxin Binders in Broiler Chickens?. Toxins. 2022; 14(10): 678. https://doi.org/10.3390/toxins14100678Srinual O. et al. Can Red Yeast (Sporidiobolus pararoseus) Be Used as a Novel Feed Additive for Mycotoxin Binders in Broiler Chickens?. Toxins. 2022; 14(10): 678. https://doi.org/10.3390/toxins14100678Ядерец В.В., Карпова Н.В., Глаголева Е.В., Петрова К.С., Шибаева А.С., Джавахия В.В. Каротиноиды: обзор основных биотехнологических способов и условий получения. Известия вузов. Прикладная химия и биотехнология. 2024; 14(1): 41–54. https://doi.org/10.21285/achb.905Yaderets V.V., Karpova N.V., Glagoleva E.V., Petrova K.S., Shibaeva A.S., Dzhavakhiya V.V. Carotenoids: Overview of the main methods and conditions of their preparation. Proceedings of Universities. Applied Chemistry and Biotechnology. 2024; 14(1): 41–54 (in Russian). https://doi.org/10.21285/achb.905Оздемиров А.А., Крупин Е.О. Регионально ориентированные стратегии повышения эффективности мясного и молочного животноводства в России: опыт Дагестана и Татарстана (2011 2022 гг.). Аграрный вестник Северного Кавказа. 2025; 15(3): 37–52. https://doi.org/10.31279/2949-4796-2025-15-3-35-50Ozdemirov A.A., Krupin E.O. Comparative Analysis of Livestock Production Indicators in the Republic of Dagestan and the Republic of Tatarstan (2011–2022). Agrarian Bulletin of the North Caucasus. 2025; 15(3): 37–52 (in Russian). https://doi.org/10.31279/2949-4796-2025-15-3-35-50Крупин Е.О., Шакиров Ш.К., Тагиров М.Ш. О некоторых результатах использования нового кормового концентрата в рационах дойных коров. Молочное и мясное скотоводство. 2017; (6): 22–25. EDN ZSIEQNKrupin E.O., Shakirov S.K., Tagirov M.Sh. Some results of the use of a new fodder concentrate in feeding of dairy cows. Dairy and beef cattle farming. 2017; (6): 22–25 (in Russian). EDN ZSIEQNТеребова С.В., Никулин Ю.П., Никулина О.А., Черепанова Е.К. Использование кормовой добавки «Левибио» при выращивании молодняка овец. Аграрная наука. 2025; (7): 62–70. https://doi.org/10.32634/0869-8155-2025-396-07-62-70.Terebova S.V., Nikulin Yu.P., Nikulina O.A., Cherepanova Е.K. Use of the feed additive “Levibio” in growing young sheep. Agrarian science. 2025; (7): 62–70 (in Russian). https://doi.org/10.32634/0869-8155-2025-396-07-62-70

The authors declare that there are no conflicts of interest present.