vetpressАграрная наукаAgrarian science0869-81552686-701XРедакция журнала "Аграрная наука"10.32634/0869-8155-2026-407-06-66-78vetpress-4214Research ArticleВЕТЕРИНАРИЯVETERINARY MEDICINEРазработка комбинированного энтеросорбента на основе диоксида кремния с иммобилизованными антитоксическими антителами для специфической профилактики и лечения эшерихиоза молодняка сельскохозяйственных животныхDevelopment of a Combined Enterosorbent Based on Silicon Dioxide with Immobilized Antitoxic Antibodies for Specific Prophylaxis of Escherichiosis in Young AnimalsМежиеваЗ. Х.MezhievaZ. Kh.

Зарина Хамзатовна Межиева, кандидат ветеринарных наук, главный специалист

Звенигородское шоссе, д. 5, Москва, 123022

Zarina Khamzatovna Mezhieva, Candidate of Veterinary Sciences, Chief Specialist 

5 Zvenigorodskoe highway, Moscow, 123022

zarina@vgnki.ruМоторыгинА. В.MotoryginA. V.

Антон Валерьевич Моторыгин, кандидат ветеринарных наук, заведующий научно-технологической лабораторией

Звенигородское шоссе, д. 5, Москва, 123022

Anton Valerievich Motorygin, Candidate of Veterinary Sciences, Head of the scientific and technological laboratory

5 Zvenigorodskoe highway, Moscow, 123022

avmotorygin@vgnki.ruАбросимоваН. С.AbrosimovaN. S.

Надежда Сергеевна Абросимова, старший научный сотрудник

Звенигородское шоссе, д. 5, Москва, 123022

Nadezhda Sergeevna Abrosimova, Senior researcher 

5 Zvenigorodskoe highway, Moscow, 123022

n.abrosimova@vgnki.ruПанинА. Н.PaninA. N.

Александр Николаевич Панин, доктор ветеринарных наук, профессор, академик Российской академии наук

Звенигородское шоссе, д. 5, Москва, 123022

Alexander Nikolaevich Panin, Doctor of Veterinary Sciences, Professor, Academician of the Russian Academy of Sciences

5 Zvenigorodskoe highway, Moscow, 123022

alexanderpanin5083@gmail.comВсероссийский государственный центр качества и стандартизации лекарственных средств для животных и кормовРоссияThe Russian State Center for Animal Feed and Drug Standardization and Quality — VGNKIRussian Federation202604072026066678Copyright © Межиева З.Х., Моторыгин А.В., Абросимова Н.С., Панин А.Н., 20262026Межиева З.Х., Моторыгин А.В., Абросимова Н.С., Панин А.Н.Mezhieva Z.K., Motorygin A.V., Abrosimova N.S., Panin A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vetpress.ru/jour/article/view/4214Актуальность

Актуальность. Настоящий обзор посвящен актуальной проблеме профилактики и лечения бактериальных желудочно-кишечных инфекций у молодняка сельскохозяйственных животных, в частности эшерихиоза. Традиционная терапия, включая парентеральное введение гипериммунных сывороток, имеет ограниченную эффективность из-за недостаточной доставки антитоксических антител в просвет кишечника. В качестве перспективной альтернативы рассматривается разработка комбинированных энтеросорбентов нового поколения, совмещающих свойства носителя и специфического антитоксина.

Методы

Методы. В работе проведен анализ современных подходов к модификации поверхности сорбентов для иммобилизации биологически активных молекул. Особое внимание уделено химической функционализации на основе силанизации с использованием 3-аминопропилтриэтоксисилана (APTES) как методу, обеспечивающему формирование стабильных ковалентных связей между поверхностью диоксида кремния и антителами. Обобщены сведения о существующих классах энтеросорбентов, применяемых в животноводстве, и обоснован выбор высокодисперсного диоксида кремния в качестве оптимальной платформы для создания таргетного препарата.

Результаты

Результаты. Практическая значимость работы заключается в научном обосновании подхода к созданию инновационного средства для специфической профилактики эшерихиоза, которое обеспечит направленную доставку и пролонгированную активность антитоксических антител непосредственно в очаге инфекции, что позволит снизить экономический ущерб в животноводстве.

Relevance

Relevance. This review addresses the current challenge of preventing and treating bacterial gastrointestinal infections in young farm animals, specifically escherichiosis. Conventional therapy, including the parenteral administration of hyperimmune sera, has limited efficacy due to insufficient delivery of antitoxic antibodies to the intestinal lumen. The development of next-generation combined enterosorbents, which integrate the properties of a carrier and a specific antitoxin, is considered a promising alternative.

Methods

Methods. The work presents an analysis of modern approaches to modifying sorbent surfaces for the immobilization of biologically active molecules. Particular attention is paid to chemical functionalization based on silanization using 3-aminopropyltriethoxysilane (APTES) as a method that ensures the formation of stable covalent bonds between the silicon dioxide surface and antibodies. Information on existing classes of enterosorbents used in animal husbandry is summarized, and the choice of highly dispersed silicon dioxide as an optimal platform for creating a targeted drug is justified.

Results

Results. The practical significance of the work lies in the scientific rationale for an approach to creating an innovative agent for the specific prophylaxis of escherichiosis. This agent will provide targeted delivery and prolonged activity of antitoxic antibodies directly at the site of infection, thereby helping to reduce economic losses in animal husbandry.

комбинированный энтеросорбентэшерихиоз молоднякаантитоксические антителадиоксид кремния (SiO₂)иммобилизация белковсиланизация (APTES)специфическая профилактикаcombined enterosorbentescherichiosis in young animalsantitoxic antibodiessilicon dioxide (SiO₂)protein immobilizationsilanization (APTES)specific prophylaxisИсследование выполнено при финансовой поддержке Российского научного фонда № 24-26-00202 https://rscf.ru/project/24-26-00202 / Авторы благодарят сотрудников кафедры микробиологии, вирусологии, эпизоотологии и ветеринарно-санитарной экспертизы Ульяновский ГАУ за помощь в редактировании и корректуре рукописи.This research was funded by Russian Science Foundation No. 24-26-00202 https://rscf.ru/project/24-26-00202 / The authors thank the staff of the Department of Microbiology, Virology, Epizootology and Veterinary-Sanitary Expertise of the Ulyanovsk State Agrarian University for their assistance in editing and proofreading the manuscript.ReferencesPeraro MD, van der Goot F.G. 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The authors declare that there are no conflicts of interest present.