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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vetpress</journal-id><journal-title-group><journal-title xml:lang="ru">Аграрная наука</journal-title><trans-title-group xml:lang="en"><trans-title>Agrarian science</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-8155</issn><issn pub-type="epub">2686-701X</issn><publisher><publisher-name>Редакция журнала "Аграрная наука"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.32634/0869-8155-2026-407-06-156-172</article-id><article-id custom-type="elpub" pub-id-type="custom">vetpress-4225</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АГРОИНЖЕНЕРИЯ И ПИЩЕВЫЕ ТЕХНОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>AGROENGINEERING AND FOOD TECHNOLOGIES</subject></subj-group></article-categories><title-group><article-title>Лактоферрин в пищевых системах: функциональные свойства, технологии производства и нормативное регулирование</article-title><trans-title-group xml:lang="en"><trans-title>Lactoferrin in Food Systems: Functional Properties, Manufacturing Technologies, and Regulatory Aspects</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1121-8139</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ребезов</surname><given-names>Я. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Rebezov</surname><given-names>Ya. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ярослав Максимович Ребезов, кандидат биологических наук, научный сотрудник,  Сектор прикладной биотехнологии;  учебно-научная исследовательская лаборатория  химико-технологического института</p><p>ул. Большая Санкт-Петербургская, 41, Великий Новгород, 173003</p></bio><bio xml:lang="en"><p>Yaroslav Maksimovich Rebezov, Candidate of biological sciences,Research Fellow, Applied Biotechnology Sector; Educational and scientific research laboratory of the Institute of Chemical Technology</p><p>41 Bolshaya Sankt-Peterburgskaya st., Veliky Novgorod, 173003</p></bio><email xlink:type="simple">yaroslavreb@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0857-5143</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ребезов</surname><given-names>М. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Rebezov</surname><given-names>M. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Максим Борисович Ребезов, доктор сельскохозяйственных наук, профессор, главный научный сотрудник</p><p>ул. им. Талалихина, 26, Москва, 109316</p></bio><bio xml:lang="en"><p>Maksim Borisovich Rebezov, Doctor of Agricultural Sciences, Professor, Chief Researcher</p><p>26 Talalikhin st., Moscow, 109316</p></bio><email xlink:type="simple">m.rebezov@fncps.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-0253-4447</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Медведева</surname><given-names>У. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Medvedeva</surname><given-names>U. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ульяна Юрьевна Медведева, кандидат сельскохозяйственных наук, доцент кафедры технологии производства и переработки сельскохозяйственной продукции химико-технологического института</p><p>ул. Большая Санкт-Петербургская, 41, Великий Новгород, 173003</p></bio><bio xml:lang="en"><p>Ulyana Yuryevna Medvedeva, Candidate of agricultural sciences, Associate Professor of the Department of technology of production and processing of agricultural products at the Institute of chemical technology</p><p>41 Bolshaya Sankt-Peterburgskaya st., Veliky Novgorod, 173003</p></bio><email xlink:type="simple">medvedevau@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Новгородский государственный университет имени Ярослава Мудрого</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Yaroslav-the-Wise Novgorod State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральный научный центр пищевых систем им. В.М. Горбатова Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Gorbatov Federal Research Center for Food Systems</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>04</day><month>07</month><year>2026</year></pub-date><volume>0</volume><issue>6</issue><fpage>156</fpage><lpage>172</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ребезов Я.М., Ребезов М.Б., Медведева У.Ю., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Ребезов Я.М., Ребезов М.Б., Медведева У.Ю.</copyright-holder><copyright-holder xml:lang="en">Rebezov Y.M., Rebezov M.B., Medvedeva U.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vetpress.ru/jour/article/view/4225">https://www.vetpress.ru/jour/article/view/4225</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Лактоферрин — это природный катионный железосвязывающий гликопротеин, естественным образом присутствующий в организме животных и человека, особенно в молозиве и молоке человека и коровы. Его многофункциональные свойства, включая антимикробную, иммуномодулирующую и антиоксидантную активность, обуславливают значительный интерес к его применению в качестве пищевого ингредиента, биологически активной добавки и компонента функциональных продуктов питания.</p></sec><sec><title>Методы</title><p>Методы. Поиск потенциально релевантных статей проводили по ключевым словаv в электронных базах данных и в открытом доступе сети Internet.</p></sec><sec><title>Результаты</title><p>Результаты. Применение лактоферрина является потенциально перспективным направлением для пищевой промышленности из-за усиления им иммуномодулирующего и антиоксидантного действия, а также увеличения сроков годности продуктов. Сегодня лактоферрин наиболее активно используется как биологически активная добавка для детских смесей, специализированных молочные продуктов на основе молока и сыворотки, продуктов переработки мяса, а также пищевых добавок. На мировом рынке лактоферрина есть определенные трудности: разработка новых, более эффективных способов очистки и производства лактоферрина, также открыт вопрос о правовом характере применения лактоферрина (в том числе рекомбинантного).</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. Lactoferrin is a natural cationic iron-binding glycoprotein naturally present in animals and humans, particularly in human and bovine colostrum and milk. Its multifunctional properties, including antimicrobial, immunomodulatory, and antioxidant activity, have generated significant interest in its use as a food ingredient, dietary supplement, and component of functional foods.</p></sec><sec><title>Methods</title><p>Methods. A keyword search for potentially relevant articles was conducted in electronic databases and open-access internet searches.</p></sec><sec><title>Results</title><p>Results. The use of lactoferrin is a potentially promising area for the food industry due to its enhanced immunomodulatory and antioxidant effects, as well as its extended shelf life. Today, lactoferrin is most actively used as a dietary supplement for infant formulas, specialized milk- and whey-based dairy products, processed meat products, and dietary supplements. The global lactoferrin market faces certain challenges: the development of new, more efficient methods for purifying and producing lactoferrin, as well as the open question of the legal nature of the use of lactoferrin (including recombinant).</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>лактоферрин</kwd><kwd>продукты питания</kwd><kwd>биологически активная добавка</kwd><kwd>йогурт</kwd><kwd>производство лактоферрина</kwd><kwd>трансгенез</kwd></kwd-group><kwd-group xml:lang="en"><kwd>lactoferrin</kwd><kwd>food</kwd><kwd>dietary supplement</kwd><kwd>yogurt</kwd><kwd>lactoferrin production</kwd><kwd>transgenesis</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Научный обзор подготовлен в рамках выполнения исследований по государственному заданию Научно-исследовательских работ № FGUS-2024-0002 Федерального научного центра пищевых систем им. В.М. Горбатова Российской академии наук.</funding-statement><funding-statement xml:lang="en">This scientific review was prepared as part of the research carried out under the state assignment for scientific research work No. FGUS-2024-0002 of the V. M. Gorbatov Federal Scientific Center for Food Systems of the Russian Academy of Sciences.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Мамонтова Т.В., Шринивас П.П. Лактоферрин — будущее пищевой промышленности. Материалы IV Ежегодных международных научно-практических чтений Ставропольского института кооперации (филиала) БУКЭП: Сборник IV международных конференций профессорско преподавательского состава и аспирантов Ставропольского института кооперации (филиала) БУКЭП. Ставрополь: Общество с ограниченной ответственностью «Издательско информационный центр «Фабула». 2018; 194–196. 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