Hepatoprotective effect of Oxymethyluracil on experimental toxic hepatitis
https://doi.org/10.32634/0869-8155-2021-348-4-17-20
Abstract
The article presents the results of a study of Oxymethyluracil effect on toxic liver damage with carbon tetrachloride. As a result of the induced toxic hepatitis in laboratory rats, a malfunction of the free radical lipid oxidation system is observed: the content of diene conjugates increases by 1.93 times and malondialdehyde — by 1.8 times in the blood serum compared to the intact group. There is a change in the indicators of liver pigmentation: the indicators of total bilirubin increased by 3.06 times, direct bilirubin — by 5.63 times, indirect bilirubin — by 2.8 times compared to the control group. After therapy with Legalon and Oxymethyluracil lipid peroxidation is inhibited and the antioxidant status of the body increases, and bilirubin indicators improve. When comparing the hepatoprotective properties of drugs in conditions of liver damage with carbon tetrachloride, the use of Oxymethyluracil is less effective than Legalon.
About the Authors
T. M. Prokhorova
Saratov State Agrarian University named after N.I. Vavilov
Russian Federation
Russian Federation
Teatralnaya pl., 1, Saratov, 410012, Russia
E. V. Popova
Saratov State Agrarian University named after N.I. Vavilov
Russian Federation
Russian Federation
Teatralnaya pl., 1, Saratov, 410012, Russia
O. A. Gurkina
Saratov State Agrarian University named after N.I. Vavilov
Russian Federation
Russian Federation
Teatralnaya pl., 1, Saratov, 410012, Russia
P. V. Smutnev
Saratov State Agrarian University named after N.I. Vavilov
Russian Federation
Russian Federation
Teatralnaya pl., 1, Saratov, 410012, Russia
M. E. Rubanova
Saratov State Agrarian University named after N.I. Vavilov
Russian Federation
Russian Federation
Teatralnaya pl., 1, Saratov, 410012, Russia
References
1. Barkova D. A., Pudovkin N. A., Salautin V. V. Features of free radical lipid oxidation in chronic liver cirrhosis//Scientific notes of the Kazan State Academy of Veterinary Medicine named after N. E. Bauman, 2018, vol. 234. No. 2, p. 40-44.
2. Skupnevsky S. V., Kaboeva B. N., Batagova F. E., Dzhioev I. G. Influence of seasonal biorhythms on lipid peroxidation in rats with carbon tetrachloride intoxication//International Journal of Applied and Fundamental Research, 2014, no. 11-5, pp. 843-846.
3. Myshkin V. A., Enikeev D. A. Oxymethyluracil and liver pathology: experimental aspect / / Medical Bulletin of Bashkortostan, 2009, vol. 4, no. 2, pp. 147-151.
4. Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes (Text with EEA relevance): European Commission: Brussels. 2010.
5. Koroljuk M.A. Metod opredelenija aktivnosti katalazy / M.A. Koroljuk, L.I. Ivanova, I.N. Majorova // Laboratornoe delo. 1988. no . pp. 16–18.
6. Stal'naya I. D., Garishvili T. G. Methods for determining the diene conjugation of unsaturated higher fatty acids / I. D. Stal'naya, T. G. Garishvili / / Modern methods in biochemistry. - M.: Meditsina. - 1977. p. 63-64.
7. Stal'naya I. D., Garishvili T. G. Method for the determination of malondialdehyde using thiobarbituric acid // Modern methods in biochemistry / Edited by V. N. Orekhovich. - Moscow: Meditsina, 1977. - p. 66 -68.
8. Prokhorova T. M., Alekseev A. A. Change in behavior and indicators of bilirubin in laboratory rats with chronic toxic hepatitis / / Bulletin of the Buryat Agricultural Academy. Filippova. - 2020. - No. 1. - From 121-126.
9. Pudovkin N. A., Salautin V. V., Prokhorova T. M. Influence of various stress factors on free-radical lipid oxidation and behavior of white rats. 2017, No. 3 (35). pp. 3-7.
10. Poperechneva T. Yu., Kutepova I. Yu. Pudovkin N. A. Kutepov A. Yu. Physiological and toxic effect of various doses of DAFS-25 on the antioxidant system of protection of the body of white rats// Voprosy normativno-pravovogo regulirovaniya veterinarii, 2010, No. 4, pp. 110-112.
Review
For citations:
Prokhorova T.M., Popova E.V., Gurkina O.A., Smutnev P.V., Rubanova M.E. Hepatoprotective effect of Oxymethyluracil on experimental toxic hepatitis. Agrarian science. 2021;(4):17-20. (In Russ.) https://doi.org/10.32634/0869-8155-2021-348-4-17-20
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