Preview

Agrarian science

Advanced search

Evaluation of the effectiveness of therapy for compensated intestinal dysbiosis in cats

https://doi.org/10.32634/0869-8155-2022-355-1-24-29

Abstract

Relevance. Despite the constant improvement of methods for correcting the intestinal microbiota, the occurrence of dysbacteriosis in various pathological processes not only does not decrease, but, on the contrary, increases. Therefore, the choice of the optimal therapeutic regimen for the correction of the lightest compensated degree of intestinal dysbiosis in cats, in our opinion, is an urgent direction of scientific research in veterinary medicine.

Methods. Evaluation of the effectiveness of pharmacotherapy in cats with compensated intestinal dysbiosis (n = 15) is given. The animals were divided by the envelope method into two experimental groups: A1 (n = 6) and A2 (n = 9). The dynamics of individual hematological and immunological blood parameters of cats with grade 1 dysbiosis in the course of their therapy (before treatment, on days 7 and 14) is shown.

Results. With compensated intestinal dysbiosis in cats, the appointment of the Purina Pro Plan dietary food shows a therapeutic effect, which leads to an overall clinical improvement as early as after 6.16±0.60 days. However, the use of the probiotic «Lactobifadol» against the background of diet therapy normalizes appetite after 2.39 days, an unpleasant odor from the oral cavity after 0.84 days, feces after 0.89 days, accelerates the overall clinical improvement of animals with intestinal dysbiosis of the 1st degree by 2.16 days earlier, when compared with the indicators of cats of the A1 group.

 

About the Authors

Yu. A. Vatnikov
Peoples’ Friendship University of Russia
Russian Federation

Vatnikov Yuri A., Doctor of Veterinary Sciences, Professor, Director of the Department of Veterinary Medicine

117198, Moscow, st. Miklukho-Maclay, 6



P. A. Rudenko
Peoples’ Friendship University of Russia; Moscow State Academy of Veterinary Medicine and Biotechnology — MVA named after K.I. Scryabin
Russian Federation

Rudenko Pavel A., Doctor of Veterinary Sciences, Associate Professor of the Department of Veterinary Medicine

117198, Moscow, st. Miklukho-Maclay, 6, 

109472, Moscow, Academician Skryabin street, 23



N. S. Bugrov
Peoples’ Friendship University of Russia
Russian Federation

Bugrov Nikolai S., Post-graduate Student of the Department of Veterinary Medicine

117198, Moscow, st. Miklukho-Maclay, 6



A. A. Rudenko
FGBOU VO “Moscow State University of Food Production”
Russian Federation

Rudenko Andrey A., Doctor of Veterinary Sciences, Professor of the Department of Veterinary Medicine

125080, Moscow, Volokolamskoe sh., 11



References

1. Kathrani A., Fascetti A.J., Larsen J.A. et all. Whole-Blood Taurine Concentrations in Cats With Intestinal Disease. J. Vet. Intern. Med. 2017; 31(4): 1067-1073.

2. Rudenko P., Vatnikov Yu., Sachivkina N. et al. Search for Promising Strains of Probiotic Microbiota Isolated from Different Biotopes of Healthy Cats for Use in the Control of Surgical Infections. Pathogens. 2021; 10(6): 667.

3. Rudenko P., Vatnikov Yu., Engashev S. et al. The role of lipid peroxidation products and antioxidant enzymes in the pathogenesis of aseptic and purulent inflammation in cats. J. Adv. Vet. Anim. Res. 2021; 8(2): 210–217.

4. Palikov V.A., Palikova Y.A., Borozdina N.A. et al. A novel view of the problem of Osteoarthritis in experimental rat model. Research Results in Pharmacology. 2020; 6(2): 19–25.

5. Yousefi M., Hoseini S.M., Aydın B. et al. Anesthetic efficacy and hemato-biochemical effects of thymol on juvenile Nile tilapia, Oreochromis niloticus. Aquaculture. 2022; 547: 737540.

6. Rudenko P., Sachivkina N., Vatnikov Y., et al. Role of microorganisms isolated from cows with mastitis in Moscow region in biofilm formation. Veterinary World. 2021; 14(1): 40-48.

7. Vatnikov Y., Shabunin S., Karamyan A., et al. Antimicrobial activity of Hypericum Perforatum L. International Journal of Pharmaceutical Research. 2020; 12(S.1): 723-730.

8. Moon C.D., Young W., Maclean P.H. et all. Metagenomic insights into the roles of Proteobacteria in the gastrointestinal microbiomes of healthy dogs and cats. Microb. Open. 2018; 7(5): e00677.

9. Older C.E., Gomes M.O.S., Hoffmann A.R. et all. Influence of the FIV Status and Chronic Gingivitis on Feline Oral Microbiota. Pathogens. 2020; 9(5): 383.

10. Rudenko P.A., Murashev A.N. Technological process of integrated probiotics sorption drugs «Dilaksil» and «Sorbelact». Russian Journal of Biopharmaceuticals. 2017; 9(3): 49-54.

11. Peirce J.M., Alviña K.J., The role of inflammation and the gut microbiome in depression and anxiety. Neurosci Res. 2019; 97(10): 1223-1241.

12. Vatnikov Yu., Shabunin S., Kulikov E. et al. The efficiency of therapy the piglets gastroenteritis with combination of Enrofloxacin and phytosorbent Hypericum Perforatum L. International Journal of Pharmaceutical Research. 2020; 12(S.2): 3064-3073.

13. Durack J., Lynch S.V., The gut microbiome: Relationships with disease and opportunities for therapy, J. Exp. Med. 2019; 216(1): 20-40.

14. Mohajeri M.H., La Fata G.G., Steinert R.E., Weber P., Relationship between the gut microbiome and brain function, Nutr Rev. 2018; 76(7): 481-496.

15. Weersma R.K., Zhernakova A., Fu J. Interaction between drugs and the gut microbiome. Gut. 2020; 69(8): 1510-1519.

16. Vatnikov Y., Shabunin S., Kulikov E. et al. Effectiveness of biologically active substances from Hypericum Perforatum L. in the complex treatment of purulent wounds. International Journal of Pharmaceutical Research. 2020; 12(4): 1108-1117.


Review

For citations:


Vatnikov Yu.A., Rudenko P.A., Bugrov N.S., Rudenko A.A. Evaluation of the effectiveness of therapy for compensated intestinal dysbiosis in cats. Agrarian science. 2022;(1):24-29. (In Russ.) https://doi.org/10.32634/0869-8155-2022-355-1-24-29

Views: 306


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 0869-8155 (Print)
ISSN 2686-701X (Online)
X