Evaluation of immunity duration following vaccination with a novel subunit marker vaccine against classical swine fever
https://doi.org/10.32634/0869-8155-2022-357-3-23-27
Abstract
The publication outlines the results of antigenic activity trials for experimental samples of a marker vaccine against classical swine fever (CSF) prepared using different types of adjuvants, as well as data on the duration of immunity upon administration of this vaccine to laboratory and naturally susceptible animals. Live vaccine “KS”, widely used for the specific prophylaxis of CSF in Russia, was used as positive control. The data obtained indicate that all experimental samples of the vaccines stimulated a pronounced immune response to CSF viral glycoprotein E2, triggering off production of virus-neutralising antibodies in immunised piglets. Antibodies possessing such specificity were detected in piglets in high concentrations over a period of 96 days after double vaccination up to the final day of the experiment. Experimental samples of the vaccine did not induce synthesis of antibodies to CSF viral glycoprotein ЕRNS, which would allow one to use the vaccine and be able to distinguish vaccinated animals from those naturally infected with field strains. This strategy, by consequence, will be valuable in the implementation of CSF eradication programs.
About the Authors
E. V. Shemelkov
LLC “Vetbiohim”
Russian Federation
Russian Federation
Shemelkov Evgeny Vladimirovich, Ph.D., Head of the quality control department
105120, Moscow, 3rd Syromyatnichesky per., 3/9
A. D. Bulgakov
LLC “Vetbiohim”
Russian Federation
Russian Federation
Bulgakov Alexander Dmitrievich, Microbiologist of the quality control department
105120, Moscow, 3rd Syromyatnichesky per., 3/9
T. S. Kulikova
LLC “Vetbiohim”
Russian Federation
Russian Federation
Kulikova Tatyana Sergeevna, Microbiologist of the quality control department
105120, Moscow, 3rd Syromyatnichesky per., 3/9
O. A. Verkhovsky
Scientific Research Institute for Diagnostics and Prevention of Human and Animal Diseases
Russian Federation
Russian Federation
Verkhovsky Oleg Anatolyevich, Doctor of Biological Sciences, President
123098, Moscow, st. Gamalei, 16-2
K. Y. Kunakov
LLC “Vetbiohim”
Russian Federation
Russian Federation
Kunakov Konstantin Yurievich, Specialist of the Department of Clinical Research and Monitoring
105120, Moscow, 3rd Syromyatnichesky per., 3/9
A. P. Kotelnikov
LLC “Vetbiohim”
Russian Federation
Russian Federation
Kotelnikov Alexander Pavlovich, Head of the department of clinical research and monitoring
105120, Moscow, 3rd Syromyatnichesky per., 3/9
T. I. Aliper
LLC “Vetbiohim”
Russian Federation
Russian Federation
Aliper Taras Ivanovich, Doctor of Biological Sciences, Chairman of the Board of Directors
105120, Moscow, 3rd Syromyatnichesky per., 3/9
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Review
For citations:
Shemelkov E.V., Bulgakov A.D., Kulikova T.S., Verkhovsky O.A., Kunakov K.Y., Kotelnikov A.P., Aliper T.I. Evaluation of immunity duration following vaccination with a novel subunit marker vaccine against classical swine fever. Agrarian science. 2022;(3):23-27. (In Russ.) https://doi.org/10.32634/0869-8155-2022-357-3-23-27
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