Some aspects of lipid metabolism in rat brain and heart tissues against the background of acute hemic hypoxia

Studies to assess the effect of acute hemic hypoxia on lipid metabolism in rat brain and heart tissues were performed on 60 white outbred rats weighing 240–260 g.

Black currant extract, medicinal raspberry extract and their mixture in the ratio 1:1 and cytochrome C were used as antihypoxants. It was found that against the background of acute hemic hypoxia, lipid metabolism disorders developed, characterized by a decrease in the proportion of total phospholipids, a decrease in the concentrations of PHH, PHEA, PHS, KL, HDL and an increase in the concentrations of S, LPH, LDL, LDONP, triglycerides and total cholesterol in brain and heart tissues of rats and calculation of atherogenicity and Castelli 1 and 2 indices confirm the development of pronounced dyslipoproteinemia, which indicates the violation of compensatory-adaptive functions of the organism and deep metabolic disorders. The use of antihypoxants levels the negative effect of hemic hypoxia on lipid metabolism in brain and heart tissues of rats, stabilizing the concentrations of lipids and phospholipids in the studied tissues and the most pronounced positive effect is observed when using a mixture of extracts of medicinal raspberry and black currant in the ratio of 1:1.

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