Fertility haplotypes of the breeding stock of cattle in the Sverdlovsk region
https://doi.org/10.32634/0869-8155-2025-392-03-62-68
Abstract
The detection of lethal and undesirable mutations in maternal Black Pied cattle populations remains relevant, despite bulls being routinely screened for a wide range of known genetic anomalies. For the first time in Sverdlovsk Oblast, a study has been initiated to investigate the carriage of lethal genes in dairy-oriented maternal cattle. For the study, 48 sexually mature cows born between 2008 and 2013 were selected from four breeding organizations in the region. Genotyping of the sampled individuals was performed using GGP Bovine 150K chips. The genotyping confirmed the latent persistence of mutant allele forms of the CD18, APAF1, SDC2, and GART genes in the herds, which cause BLAD syndrome and fertility haplotypes HH1, HH3, and HH4, respectively. No carriers of syndactyly, citrullinemia, or DUMPS pathologies were identified. The highest proportion of heterozygous individuals was associated with the lethal HH1 haplotype (7%), while the carriage rates for other mutations did not exceed 4%. The distribution of carriers across agricultural enterprises was uneven, reflecting individual farm practices in sourcing semen from breeding organizations for artificial insemination. Statistical analysis identified five carrier bulls with lethal alleles, and genealogical methods demonstrated a high probability of mutation carriage for three of them. Despite the removal of carrier bulls, lethal gene forms may persist in the population through heterozygous cows. The results highlight the widespread prevalence of the studied alleles across most genealogical lines of Holstein-origin bulls.
Supporting agencies: The research was carried out with the financial support of the Russian Science Foundation No. 23-26-00260. https://rscf.ru/project/23-26-00260/
About the Authors
O. E. Lihodeevskaya
Ural State Agrarian University
Russian Federation
Russian Federation
Oksana E. Lihodeevskaya - Candidate of Science in Biology, Associate Professor, Head of the Laboratory of Molecular and Biological Research.
42 Karl Liebknecht Str., Yekaterinburg, 620075
G. A. Lihodeevskiy
Ural State Agrarian University
Russian Federation
Russian Federation
Georgiy A. Lihodeevskiy - Junior Researcher.
42 Karl Liebknecht Str., Yekaterinburg, 620075
P. S. Bogatova
Ural State Agrarian University
Russian Federation
Russian Federation
Polina S. Bogatova - Junior Researcher.
42 Karl Liebknecht Str., Yekaterinburg, 620075
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Review
For citations:
Lihodeevskaya O.E., Lihodeevskiy G.A., Bogatova P.S. Fertility haplotypes of the breeding stock of cattle in the Sverdlovsk region. Agrarian science. 2025;(3):62-68. (In Russ.) https://doi.org/10.32634/0869-8155-2025-392-03-62-68
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