Study of the clinical and immunological status of animals during immunocorrection of thermal injury in animals in an experiment

Abstract

In these studies, the main goals were to improve methods for diagnosing toxemia in burns in animals and to develop methods for immunologically overcoming burn autointoxication, which may be a pathogenetic justification for the development of methods for treating animals with burns. As a result of experiments conducted on 5 dogs in which thermal burns were simulated by contact, it was found that the formation and development of burn disease had a negative effect on physical parameters. Thus, respiration rates were higher on day 1 by 27.8% of the norm, by day 5 the indicators increased by another 3.9% compared to the primary indicators, by day 10 the respiratory rates decreased by 8%, by the 20th — by another 5% compared to the primary data, and by the 30th day they were already making up the physiological norm. After the application of autoserum, the data of immunobiochemical parameters leveled off relatively quickly — by the 20th day of the experiment, which indicated a high therapeutic effect of the applied treatment method. When studying the healing of simulated wounds, accelerated recovery of wound areas on the extremities in dogs was observed by an average of 7–10 days.