Pathogenetic factors of occurrence and progression of cardiorenal syndrome in cats

This article examines the issues of studying pathogenetic correlative links between various clinical and laboratory parameters in cats with cardiorenal syndrome. A significant correlation was found between the level of creatininemia and the pulse rate (r = 0.4), respiratory rate (r = 0.7), sleep breathing rate (r = 0.6), systolic (r = 0.3), diastolic (r = 0.3), mean arterial pressure (r = 0.3), QRS complex duration (r = 0.5), QT interval (r = 0.3), P wave voltage (r = 0.3) and R in the second standard lead (r = 0.4), left atrium size (r = 0.7), interventricular septum thickness in diastole (r = 0.7), left ventricular free wall thickness in diastole (r = 0.6), end-diastolic size (r = -0.6; p ≤ 0.05), end-systolic size of the left ventricular chamber (r = -0.5), serum alanine aminotransferase (r = 0.5), lactate dehydrogenase (r = 0.6), aspartic aminotransferase (r = 0.7), creatinine phosphokinase (r = 0.7), cardiac troponin (r = 0.5), serum concentration of urea (r = 0.7), ketone bodies (r = 0.7), malondialdehyde (r = 0.7), diene conjugates (r = 0.7), ceruloplasmin (r = 0.6), superoxide dismutase activity (r = -0.5), catalase (r = -0.7), glutathione peroxidase (r = -0.6). In the body of cats with cardiorenal syndrome, there is an activation of the sympathoadrenal system, myocardial remodeling processes in the form of concentric hypertrophy, oxidative stress and damage to the cell membranes of cardiomyocytes and other cells of the body, while there is an increase in the mass and number of cardiomyocytes, a violation of the diastolic function of the myocardium, a syndrome of damage to the cell membranes of cardiac cells occurs, progressive prerenal azotemia develops against the background of chronic decompensation of the circulatory organs. Changes in the correlative pathogenetic relationships between clinical and laboratory parameters in cats with cardiorenal syndrome can be considered as predictors of a more malignant course of the pathological process.

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