Preview

Agrarian science

Advanced search

Endogenous losses of minerals in the animal body and factors affecting their availability (review)

https://doi.org/10.32634/0869-8155-2025-399-10-91-101

Abstract

Endogenous nutrient losses in farm animals play a key role in regulating metabolism and maintaining homeostasis in the animal body. To reduce them, it is necessary to carry out nutritional support — to introduce minerals into the feed, which are necessary to restore the metabolism of animals.

The purpose of the study is to analyze the publications of scientific research on the state of micronutrient supply of diets, their role for farm animals and to identify factors affecting the endogenous loss of essential elements from the body from 2010 to 2025.

When searching for literature sources, traditional and mixed methods were used, as well as automated search. Knowledge of the mechanisms of endogenous losses and their biological significance will not only increase animal productivity, but also improve the environmental sustainability of agriculture. Modern feeding methods, the use of enzymes, mineral additives and proper breeding will significantly reduce nutrient losses, which is an important step towards more efficient and sustainable animal husbandry. Thus, maintaining a stable level of minerals in the body of animals is possible only by providing nutrients to each cell. This is achieved either by increasing the daily intake of these elements or by using forms with improved absorption, such as nano- and organometallic compounds.

About the Authors

V. V. Grechkina
Federal Scientific Center of Biological Systems and Agrotechnologies of the Russian Academy of Sciences; Orenburg State Agrarian University
Russian Federation

Viktoria Vladimirovna Grechkina - Candidate of Biological Sciences, 29 January 9th Str., Orenburg, 460000;

18 Chelyuskintsev Str., Orenburg, 460014



E. V. Sheida
Federal Scientific Center of Biological Systems and Agrotechnologies of the Russian Academy of Sciences; Orenburg State University
Russian Federation

Elena Vladimirovna Sheida - Doctor of Biological Sciences, 29 January 9th Str., Orenburg, 460000;

13 Pobedy Ave., Orenburg, 460018



O. V. Kvan
Federal Scientific Center of Biological Systems and Agrotechnologies of the Russian Academy of Sciences; Orenburg State University
Russian Federation

Olga Vilorievna Kvan - Doctor of Biological Sciences, 29 January 9th Str., Orenburg, 460000;

13 Pobedy Ave., Orenburg, 460018



M. A. Desyatkov
Federal Scientific Center of Biological Systems and Agrotechnologies of the Russian Academy of Sciences; Orenburg State Agrarian University
Russian Federation

Mikhail Alexandrovich Desyatkov - Laboratory Researcher, 29 January 9th Str., Orenburg, 460000;

18 Chelyuskintsev Str., Orenburg, 460014



N. V. Soboleva
Orenburg State Agrarian University
Russian Federation

Natalia Vladimirovna Soboleva - Candidate of Agricultural Sciences, 

18 Chelyuskintsev Str., Orenburg, 460014



References

1. Zhao J., Li Z., Lyu M., Liu L., Piao X., Li D. Evaluation of available energy and total tract digestibility of acid-hydrolyzed ether extract of cottonseed oil for growing pigs by the difference and regression methods. Asian-Australasian Journal of Animal Sciences. 2017; 30(5): 712–719. https://doi.org/10.5713/ajas.16.0546

2. Sidelnikova V.I., Chernitsky A.E., Retsky M.I. Endogenous intoxication and inflammation: reaction sequence and informativity of the markers (review). Agricultural Biology. 2015; 50(2): 152–161. https://doi.org/10.15389/agrobiology.2015.2.152eng

3. Jaworski N.W., Stein H.H. Disappearance of nutrients and energy in the stomach and small intestine, cecum, and colon of pigs fed cornsoybean meal diets containing distillers dried grains with solubles, wheat middlings, or soybean hulls. Journal of Animal Science. 2017; 95(2): 727–739. https://doi.org/10.2527/jas.2016.0752

4. Lyu Z.Q. et al. Adaptation duration for net energy determination of high fiber diets in growing pigs. Animal Feed Science and Technology. 2018; 241: 15–26. https://doi.org/10.1016/j.anifeedsci.2018.04.008

5. Araújo C.S.S. et al. Different dietary trace mineral sources for broiler breeders and their progenies. Poultry Science. 2019; 98(10): 4716–4721. https://doi.org/10.3382/ps/pez182

6. Kvan O.V. Endogenous losses of substances: optimization of micronutrient supply of farm animal diets (review). Animal Husbandry and Fodder Production. 2023; 106(4): 148–163 (in Russian). https://doi.org/10.33284/2658-3135-106-4-148

7. Gamko L.N., Gulakov A.N., Novikova E.V., Ryazhnov A.A. Influence of natural mineral additiveson productivity of young cattle. Tavricheskiy nauchnyy obozrevatel’. 2016; (5–2): 106–110 (in Russian). https://www.elibrary.ru/wckxlv

8. Sabitov M.T., Farkhutdinova A.R., Farkhutdinov I.M., Malikova M.G. Economic efficiency of complex mineral and vitamin feed supplement «Nadezhda» in the diet of calves. Vestnik Bashkir State Agrarian University. 2020; (1): 106–110 (in Russian). https://doi.org/10.31563/1684-7628-2020-53-1-106-110

9. Bogdanovich D.M., Razumovsky N.P. Natural microbial complex in feeding young cattle. Innovative development of agro-food technologies. Proceedings of the International scientific and practical conference. Moscow: Sfera. 2020; 22–26 (in Russian). https://www.elibrary.ru/bmqjai

10. Arylov Yu.N., Ubushaev B.S., Moroz N.N. The influence of the concentration of minerals in the feeding regime on nutrient utilization by ruminants. Agrarian science. 2017; (11–12): 50–52 (in Russian). https://www.elibrary.ru/qimnjv

11. Jiao L. et al. Preparation, characterization, antimicrobial and cytotoxicity studies of copper/zinc- loaded montmorillonite. Journal of Animal Science and Biotechnology. 2017; 8: 27. https://doi.org/10.1186/s40104-017-0156-6

12. Marques R.S. et al. Effects of organic or inorganic cobalt, copper, manganese, and zinc supplementation to late-gestating beef cows on productive and physiological responses of the offspring. Journal of Animal Science. 2016; 94(3): 1215–1226. https://doi.org/10.2527/jas.2015-0036

13. Vorontsov G.P., Antonov V.N. Trace element status influence on reproductive function in cattle. StudNet. 2022; 5(2): 956–971 (in Russian). https://www.elibrary.ru/tmhfih

14. Karimova M.O., Irgashev T.A., Baygenov F.N., Kosilov V.I., Rebezov M.B. Metabolism of essential amino acids in the calf body under the influence of the fodder additive. Izvestia Orenburg State Agrarian University. 2020; (4): 302–306 (in Russian). https://www.elibrary.ru/iujjpa

15. Kostomakhin N.M., Ivanova A.S. The influence of bioplexes of zinc and copper on morphological and biochemical blood parameters and milk productivity of cows. Feeding of agricultural animals and feed production. 2019; (6): 23–28 (in Russian). https://www.elibrary.ru/azxynl

16. Razumovsky N.P. How to normalize rumen digestion in cows. Nashe sel’skoye khozyaystvo. 2020; (2): 22–29 (in Russian). https://www.elibrary.ru/lealvy

17. Espinosa C.D., Stein H.H. Digestibility and metabolism of copper in diets for pigs and influence of dietary copper on growth performance, intestinal health, and overall immune status: a review. Journal of Animal Science and Biotechnology. 2021; 12: 13. https://doi.org/10.1186/s40104-020-00533-3

18. Ebbing M.A. et al. An investigation on iron sources fed to broiler breeder hens and the corresponding color of laid eggshells on the performance of the resulting progeny. Journal of Applied Poultry Research. 2019; 28(1): 184–193. https://doi.org/10.3382/japr/pfy064

19. Byrne L., Murphy R.A. Relative Bioavailability of Trace Minerals in Production Animal Nutrition: A Review. Animals. 2022; 12(15): 1981. https://doi.org/10.3390/ani12151981

20. Sai Kumar B.A.A. Hormonal Regulation of Metabolism, Water, and Minerals. Das P.K., Sejian V., Mukherjee J., Banerjee D. (eds.). Textbook of Veterinary Physiology. Singapore: Springer. 2023; 391–415. https://doi.org/10.1007/978-981-19-9410-4_16

21. De Grande A. et al. Dietary zinc source impacts intestinal morphology and oxidative stress in young broilers. Poultry Science. 2020; 99(1): 441–453. https://doi.org/10.3382/ps/pez525

22. Lv G. et al. Effects of Different Trace Elements and Levels on Nutrients and Energy Utilization, Antioxidant Capacity, and Mineral Deposition of Broiler Chickens. Agriculture. 2023; 13(7): 1369. https://doi.org/10.3390/agriculture13071369

23. Karimova A.M., Sizova E.A. Use of nitrogen and metabolic energy in polygastric animals when feeding the diet with microelements in the ultradispersed form. Collection of Scientific Papers of KRCAHVM. 2022; 11(1): 51–54 (in Russian). https://doi.org/10.48612/sbornik-2022-1-10

24. Kurilkina M.Ya., Kholodilina T.N., Muslyumova D.M., Atlanderova K.N., Zavyalov O.A. The effect of finely dispersed metal particles on the digestibility of nutrients and energy exchange in the body of young cattle. Herald of beef cattle breeding. 2017; (4): 197–203 (in Russian). https://www.elibrary.ru/kasrfi

25. Abramov S.S., Goridovets E.V., Sobolev D.T. Dynamics of some indices of mineral and vitamin metabolism at high-yielding cows in the treatment of polimorbid internal pathology. Scientific notes of the educational institution «Vitebsk Order “Badge of Honor” State Academy of Veterinary Medicine». 2017; 53(3): 3–6 (in Russian). https://www.elibrary.ru/zqnwej

26. Fisinin V.I., Miroshnikov S.A., Sizova E.A., Ushakov A.S., Miroshnikova E.P. Metal particles as trace-element sources: current state and future prospects. World’s Poultry Science Journal. 2018; 74(3): 523–540. https://doi.org/10.1017/S0043933918000491

27. Prasad R., Bhattacharyya A., Nguyen Q.D. Nanotechnology in Sustainable Agriculture: Recent Developments, Challenges, and Perspectives. Frontiers in Microbiology. 2017; 8: 1014. https://doi.org/10.3389/fmicb.2017.01014

28. Sizova Е.А., Korolev V.L., Makaev Sh.A., Miroshnikova E.P., Shakhov V.A. Morphological and biochemical blood parameters in broilers at correction with dietary copper salts and nanoparticles. Agricultural Biology. 2016; 51(6): 903–911. https://doi.org/10.15389/agrobiology.2016.6.903eng

29. Brown K. et al. Microbiota alters the metabolome in an age- and sex- dependent manner in mice. Nature Communications volume. 2023; 14: 1348. https://doi.org/10.1038/s41467-023-37055-1

30. Shoshin D.E., Erofeev N.G., Sizova E.A., Pavlova M.Yu. Stress as a limiting factor in animal husbandry (review). Animal Husbandry and Fodder Production. 2024; 107(3): 138–162 (in Russian). https://doi.org/10.33284/2658-3135-107-3-138

31. Speshilova N.V., Kosilov V.I., Andrienko D.A. Production potential of dairy cattle breeding in the Southern Urals. Herald of beef cattle breeding. 2014; (3): 69–75. https://www.elibrary.ru/ssyior

32. Kaplanov M.T., Isyakaeva R.R. Optimizing technologies of feeding laboratory animals with the experimental compound feed. Modern Issues of Biomedicine. 2023; 7(4): 11 (in Russian). https://doi.org/10.24412/2588-0500-2023_07_04_11

33. Chrystal P.V., Moss A.F., Khoddami A., Naranjo V.D., Selle P.H., Liu S.Y. Effects of reduced crude protein levels, dietary electrolyte balance, and energy density on the performance of broiler chickens offered maize-based diets with evaluations of starch, protein, and amino acid metabolism. Poultry Science. 2020; 99(3): 1421–1431. https://doi.org/10.1016/j.psj.2019.10.060

34. Usmanova E.N., Zubochenko D.V., Ostapchuk P.S., Kuevda T.A. Breeding of beef cattle to increase the efficiency of feed intake. Proceedings of Nizhnevolzskiy agrouniversity complex: science and higher vocational education. 2022; (4): 270–286 (in Russian). https://www.elibrary.ru/usetwo

35. Mion B. et al. Effects of replacing inorganic salts of trace minerals with organic trace minerals in pre- and postpartum diets on feeding behavior, rumen fermentation, and performance of dairy cows. Journal of Dairy Science. 2022; 105(8): 6693–6709. https://doi.org/10.3168/jds.2022-21908

36. Li J. et al. Zinc Intakes and Health Outcomes: An Umbrella Review. Frontiers in Nutrition. 2022; 9: 798078. https://doi.org/10.3389/fnut.2022.798078

37. Molenda M., Kolmas J. The Role of Zinc in Bone Tissue Health and Regeneration — a Review. Biological Trace Element Research. 2023; 201(12): 5640‒5651. https://doi.org/10.1007/s12011-023-03631-1

38. Roeber F., Jex A.R., Gasser R.B. Impact of gastrointestinal parasitic nematodes of sheep, and the role of advanced molecular tools for exploring epidemiology and drug resistance — an Australian perspective. Parasites & Vectors. 2013; 6: 153. https://doi.org/10.1186/1756-3305-6-153

39. Reed R.G., Raison C.L. Stress and the Immune System. Esser C. (ed.). Environmental Influences on the Immune System. Vienna: Springer. 2016; 97–126. https://doi.org/10.1007/978-3-7091-1890-0_5

40. Li W., Angel R., Plumstead P.W., Enting H. Effects of limestone particle size, phytate, calcium source, and phytase on standardized ileal calcium and phosphorus digestibility in broilers. Poultry Science. 2021; 100(2): 900‒909. https://doi.org/10.1016/j.psj.2020.10.075

41. Beane K.E. et al. Effects of dietary fibers, micronutrients, and phytonutrients on gut microbiome: a review. Applied Biological Chemistry. 2021; 64: 36. https://doi.org/10.1186/s13765-021-00605-6

42. Yang Z. et al. Preliminary analysis showed country-specific gut resistome based on 1267 feces samples. Gene. 2016; 581(2): 178‒182. https://doi.org/10.1016/j.gene.2016.01.043

43. Scherzad A., Meyer T., Kleinsasser N., Hackenberg S. Molecular Mechanisms of Zinc Oxide Nanoparticle-Induced Genotoxicity. Materials. 2017; 10(12): 1427. https://doi.org/10.3390/ma10121427

44. Uerlings J. et al. in vitro prebiotic potential of agricultural byproducts on intestinal fermentation, gut barrier and inflammatory status of piglets. British Journal of Nutrition. 2020; 123(3): 293‒307. https://doi.org/10.1017/S0007114519002873

45. Fan X., Yang F., Nie C., Ma L., Cheng C., Haag R. Biocatalytic Nanomaterials: A New Pathway for Bacterial Disinfection. Advanced Materials. 2021; 33(33): 2100637. https://doi.org/10.1002/adma.202100637

46. Patra A., Lalhriatpuii M. Progress and Prospect of Essential Mineral Nanoparticles in Poultry Nutrition and Feeding — a Review. Biological Trace Element Research. 2020; 197(1): 233‒253. https://doi.org/10.1007/s12011-019-01959-1

47. Adegbeye M.J. et al. Nanoparticles in Equine Nutrition: Mechanism of Action and Application as Feed Additives. Journal of Equine Veterinary Science. 2019; 78: 29‒37. https://doi.org/10.1016/j.jevs.2019.04.001

48. Bhagat S., Singh S. Nanominerals in nutrition: Recent developments, present burning issues and future perspectives. Food Research International. 2022; 160: 111703. https://doi.org/10.1016/j.foodres.2022.111703

49. Mohd Yusof H., Mohamad R., Zaidan U.H., Abdul Rahman N.A. Microbial synthesis of zinc oxide nanoparticles and their potential application as an antimicrobial agent and a feed supplement in animal industry: a review. Journal of Animal Science and Biotechnology. 2019; 10: 57. https://doi.org/10.1186/s40104-019-0368-z

50. Sheida E.V., Miroshnikov S.A., Duskaev G.K., Ryazanov V.A., Grechkina V.V. Changes in the parameters of ruminal digesta in vitro when using sunflower husk and zinc in ultrafine form. Agrarian science. 2022; (6): 43–47 (in Russian). https://doi.org/10.32634/0869-8155-2022-360-6-43-47

51. Kvan O.V., Sizova E.A., Vershinina I.A. Influence of ultrafine particles of copper and iron on the intestinal microbiocenosis of broiler chicken. Agrarian science. 2024; (2): 61–65 (in Russian). https://doi.org/10.32634/0869-8155-2024-379-2-61-65


Review

For citations:


Grechkina V.V., Sheida E.V., Kvan O.V., Desyatkov M.A., Soboleva N.V. Endogenous losses of minerals in the animal body and factors affecting their availability (review). Agrarian science. 2025;(10):91-101. (In Russ.) https://doi.org/10.32634/0869-8155-2025-399-10-91-101

Views: 14


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 0869-8155 (Print)
ISSN 2686-701X (Online)