Association of the rs8193046 polymorphism of the TLR4 gene with the elemental composition of the blood serum of red steppe cows
https://doi.org/10.32634/0869-8155-2025-399-10-121-132
Abstract
In recent years, the study of genetic factors affecting the immune response, disease resistance and productivity of animals has attracted considerable attention from breeders. One of these factors is the toll-like receptor 4 (TLR4), which plays a key role in the immune response. The receptor responds to lipopolysaccharide components of the bacterial cell wall. Ten functional TLRs (TLR1 to TLR10) have been identified in cattle, each of which has evolved to recognize specific pathogen-associated molecular patterns (PAMPs). Genetic polymorphisms in TLR genes can affect metabolism associated with the absorption and distribution of macro- and microelements, as well as determine differences in their content in tissues and blood serum.
The purpose of this study is to study the effect of the rs8193046 polymorphism of the TLR4 gene on the content of leukocytes and the elemental composition of the blood serum of cows of the red steppe breed.
For the first time, a connection was found between allelic variants of the TLR4 gene and the content of elements in the blood serum and immunity indices in dairy cows of this breed. The GG genotype of the TLR4 gene was associated with a higher content of macroelements, such as calcium and phosphorus, as well as with a lower level of toxic microelements, including cadmium. The presence of carriers of alternative alleles in the herd of the Red Steppe breed opens up opportunities for selection aimed at increasing resistance to infectious diseases.
Supporting agencies: The research was carried out in accordance with the research plan for 2025–2027 of the Federal Scientific Center for Biological Systems and Agricultural Technologies of the Russian Academy of Sciences (No. FNWZ-2025-0001).
About the Authors
E. I. Tarasova
Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences
Russian Federation
Russian Federation
Ekaterina Ivanovna Tarasova - Junior Research Аssistant,
29 9th January Str., Orenburg, 460000
E. A. Sizova
Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences
Russian Federation
Russian Federation
Elena Anatolyevna Sizova - Doctor of Biological Sciences, Associate Professor,
29 9th January Str., Orenburg, 460000
E. V. Yausheva
Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences
Russian Federation
Russian Federation
Elena Vladimirovna Yausheva - Candidate of Biological Sciences,
29 9th January Str., Orenburg, 460000
S. V. Lebedev
Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences
Russian Federation
Russian Federation
Svyatoslav Valerievich Lebedev - Doctor of Biological Sciences, Corresponding Member
Russian Academy of Sciences,
29 9th January Str., Orenburg, 460000
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Tarasova E.I., Sizova E.A., Yausheva E.V., Lebedev S.V. Association of the rs8193046 polymorphism of the TLR4 gene with the elemental composition of the blood serum of red steppe cows. Agrarian science. 2025;(10):121-132. (In Russ.) https://doi.org/10.32634/0869-8155-2025-399-10-121-132
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