Experimental study of the use of mesh implants in perineal hernias in laboratory animals

The problem of choosing the optimal mesh implant for hernioplasty remains relevant due to the risk of postoperative complications, in particular, wrinkling of the graft. The article presents studies on the comparative study of tissue reaction, inflammatory response and degree of wrinkling after implantation of polypropylene mesh «ESFIL» and titanium mesh «Titanovy Shelk» in simulated hernias in laboratory rats. The experiment was conducted on 30 nonlinear male rats with a model of perineal hernia. The animals are divided into three groups: control (n = 6, suturing hernia), 1st experimental (n = 12, implantation of «Titanovy Shelk» mesh) and 2nd experimental (n = 12, implantation of «ESFIL» mesh). Wrinkling was assessed by measuring the area of implants on the 30th and 90th day and by hematological indicators. The degree of wrinkling of the mesh «Titanovy Shelk» is 5.5 ± 0.8%, which is statistically significantly lower (p < 0.01) than that of the mesh «ESFIL» (22.1 ± 2.3%). On the 14th day, animals with a polypropylene mesh had higher levels of leukocytes and their subpopulations, indicating the continuation of the inflammatory process. Implant «Titanium Silk» demonstrated better biocompatibility, minimal contraction and faster recovery of laboratory animals, which allows recommending it for use in veterinary practice in the treatment of perineal hernias.

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