Pharmacokinetics of azitromycin in the blood plasma of pigs following single intramuscular administration of Zitrex

Abstract

Pharmacokinetics of azithromycin in the blood plasma of pigs was investigated following single intramuscular administration of Zitrex as a part of the preclinical studies. Zitrex, containing 100 mg/ml of azithromycin as the active substance, was administered to 6 piglets once intramuscularly in the neck area at the dose of 1 ml/20 kg, which corresponds to 5 mg/kg of azithromycin. In 1; 3; 6; 9; 12; 18; 24; 36; 48; 60; 72; 84 and 96 hours following Zitrex administration blood samples were collected and azithromycin concentrations in blood plasma were analyzed by high performance liquid chromatography using a fluorescent detection. The pharmacokinetic profile of azitromicin in blood plasma of pigs was established. The data obtained allow designating the tested substance as a «long-lived» compound.