Pharmacokinetics of tiamulin and doxycicline in the blood plasma of piglets following single intramuscular administration of Tiacyclin solution for injection

Abstract

Pharmacokinetics of tiamulin and doxycicline in the blood plasma of piglets was investigated following single intramuscular administration of Tiacyclin solution for injection as a part of the preclinical studies. Tiacyclin solution for injection, was administered to 6 piglets once intramuscularly in the neck area at the dose of 1 ml/12,5 kg. In 0; 0,5; 1,0; 1,5; 3,0; 6,0; 12,0; 18,0; 24,0; 48,0 and 96,0 hours following Tiacyclin administration blood samples were collected and tiamulin and doxycicline concentrations in blood plasma were analyzed by high performance liquid chromatography using a fluorescent detection. The pharmacokinetic profile of tiamulin and doxycicline in blood plasma of piglets was established.