The influence of the anti-stress pharmacological complex “SPAO” on the effectiveness of preventive immunization of chickens against Newcastle disease

Abstract

Methodology. The assessment of the appropriateness of using the anti-stress pharmacological complex of SPAO for prophylactic immunization of hens with egg productivity against Newcastle disease was started at 45 days old before intramuscular vaccination against Newcastle disease with Gallimune ND vaccine at 47–48 days old. SPAO-complex — stress protector antioxidant — pharmacological complex for birds was developed at the Department of Morphology, Physiology and Pharmacology of the South Ural State Agrarian University, which was used at a dose of 185 mg/kg of body weight according to the scheme with water through a system of medications two days before, on the day of exposure and within two days after exposure to stress factors. Antibodies to the Newcastle disease virus were tested by hem agglutination inhibition test.

Results. As a result, it was proved that vaccinations by parenteral administration of vaccines cause the development of non-specific adaptive reactions in chickens. The level of development of reactions corresponds to the formation of stress. The use of the SPAO-complex reduces the immunosuppressive effect of the hypothalamic-pituitaryadrenal system during the development of adaptive reactions in birds under industrial stresses. In the prophylaxis of Newcastle disease chickens of the egg productivity direction on the background of stress prevention by the pharmacological complex of SPAO antibody production is more uniform throughout the herd. In the experimental group, titers are in the range of 9.40–13.40 log2, in the control group — 8.52–12.36. The level of statistical differences in the intensity of antibody production log2 is at the level of P = 0.0277. After transferring the hens to the production shop in the experimental group a higher level of productivity is noted compared to the control: egg production in the experimental group is 2.04% higher, the livestock safety over the period from 105 to 250 days of life of hens reached the highest values in the experimental group and amounted to 99.72%, in the control group — 99.44%.