Pharmacokinetics of doxycycline and tiamulin in calves body after using the injection form of Tiacycline®
https://doi.org/10.32634/0869-8155-2020-341-9-12-14
Abstract
Pharmacokinetics of tiamulin and doxycicline in the blood plasma of calves was investigated following single intramuscular administration of Tiacyclin solution for injection as a part of the preclinical studies. Tiacyclin® solution for injection, was administered to 6 calves once intramuscularly in the neck area at the dose of 1 ml/12,5 kg. In 0; 0,5; 1,0; 1,5; 3,0; 6,0; 12,0; 18,0; 24,0; 48,0 and 96,0 hours following Tiacyclin administration blood samples were collected and tiamulin and doxycicline concentrations in blood plasma were analyzed by high performance liquid chromatography using a fluorescent detection. The pharmacokinetic profile of tiamulin and doxycicline in blood plasma of calves was established.
About the Authors
S. I. Avchuk
LLC SBC «Pharmbiomed»
Russian Federation
candidate of chemical sciences
Russian Federation
candidate of chemical sciences
S. I. Chukina
LLC SBC «Pharmbiomed»
Russian Federation
candidate of biological sciences
Russian Federation
candidate of biological sciences
N. Y. Morozov
Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K.I. Skryabin
Russian Federation
postgraduate student
Russian Federation
postgraduate student
E. M. Sazonova
LLC «VIC – animal health»
Russian Federation
Russian Federation
candidate of biological sciences
Moscow
B. V. Violin
All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology – a branch of the FSBSI "Federal Scientific Center – AllRussian Research Institute of Experimental Veterinary Medicine of the Russian Academy of Sciences
Russian Federation
candidate of veterinary sciences
Russian Federation
candidate of veterinary sciences
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Review
For citations:
Avchuk S.I., Chukina S.I., Morozov N.Y., Sazonova E.M., Violin B.V. Pharmacokinetics of doxycycline and tiamulin in calves body after using the injection form of Tiacycline®. Agrarian science. 2020;(9):12-14. (In Russ.) https://doi.org/10.32634/0869-8155-2020-341-9-12-14
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