Генетическая архитектура признаков воспроизводства свиней породы ландрас российской репродукции
https://doi.org/10.32634/0869-8155-2023-372-7-31-39
Аннотация
Актуальность. В настоящее время развитие молекулярной и популяционной генетики является актуальной задачей. Необходимость выявления достоверных генов-кандидатов связано с увеличением поголовья свиней и увеличением качества выходной продукции — как племенной, так и мясной. В связи с этим метод полногеномного анализа решает вопросы генетической обусловленности количественных и хозяйственно полезных признаков.
Методы. В исследовании метод GWAS применялся по воспроизводительным показателям свиноматок породы ландрас.
Результаты. Были выявлены и описаны 35 достоверных и имеющих биологический функционал генов-кандидатов, расположенных вблизи или внутри идентифицированных значимых SNP, и отвечающих за различные воспроизводительные показатели организма свиноматок. Гены были отнесены к двум кластерам, из них 20 генов относились к 1-му кластеру, отвечавшему за митохондриальный и сопряженный транспорт электронов, синтез АТФ, а также связывание жирных кислот и триптофана (AFF4, IL13, IL4, IRF1, SHROOM1, IL-5, UQCRQ, MRPL13, TTR, ENPEP, NOL4, PCDH7, DSG3, RASSF6, ALB, AFP, ANKRD17, SOX9), и 15 — ко 2-му, связанному с ответом на бактериальную и вирусную инфекцию (YTHDC2, KIF3A, EYA1, DSG2, DSG4, PPIH, RNF125, TRAPPC8, PITX2, KIAA1462, MTPAP, JMJD6, METTL23, SRSF2 и U2AF1).
Об авторах
А. А. Белоус
Федеральный исследовательский центр животноводства — ВИЖ им. академика Л.К. Эрнста
Россия
Россия
Анна Александровна Белоус, кандидат биологических наук, лаборатория генетических технологий в агро- и аквахозяйстве,
Дубровицы, 60, Подольск, Московская обл., 142132
В. В. Волкова
Федеральный исследовательский центр животноводства — ВИЖ им. академика Л.К. Эрнста
Россия
Россия
Валерия Владимировна Волкова, кандидат биологических наук, лаборатория функциональной и эволюционной геномики животных,
Дубровицы, 60, Подольск, Московская обл., 142132
А. А. Решетникова
Федеральный исследовательский центр животноводства — ВИЖ им. академика Л.К. Эрнста
Россия
Россия
Анастасия Александровна Решетникова, младший научный сотрудник, лаборатория генетических технологий в агро- и аквахозяйстве,
Дубровицы, 60, Подольск, Московская обл., 142132
П. И. Отраднов
Федеральный исследовательский центр животноводства — ВИЖ им. академика Л.К. Эрнста
Россия
Россия
Петр Ильич Отраднов, младший научный сотрудник, лаборатория генетических технологий в агро- и аквахозяйстве, отдел популяционной генетики и генетических основ разведения животных,
Дубровицы, 60, Подольск, Московская обл., 142132
Н. А. Зиновьева
Федеральный исследовательский центр животноводства — ВИЖ им. академика Л.К. Эрнста
Россия
Россия
Наталия Анатольевна Зиновьева, доктор биологических наук, академик РАН, профессор, директор,
Дубровицы, 60, Подольск, Московская обл., 142132
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Рецензия
При поддержке: Исследование выполнено при финансовой поддержке Российского научного фонда (проект № 21-76-10038).
Для цитирования:
Белоус А.А., Волкова В.В., Решетникова А.А., Отраднов П.И., Зиновьева Н.А. Генетическая архитектура признаков воспроизводства свиней породы ландрас российской репродукции. Аграрная наука. 2023;(7):31-39. https://doi.org/10.32634/0869-8155-2023-372-7-31-39
For citation:
Belous A.A., Volkova V.V., Reshetnikova A.A., Otradnov P.I., Zinovyeva N.A. Genetic architecture of reproductive traits in Russian Landrace pigs. Agrarian science. 2023;(7):31-39. (In Russ.) https://doi.org/10.32634/0869-8155-2023-372-7-31-39
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