The influence of adjuvants ISA 61 and ISA 50 on the antigenic activity, the ability to form colostral immunity and the effectiveness of experimental samples of the vaccine KOMBOVAC-A
https://doi.org/10.32634/0869-8155-2024-383-6-44-49
Abstract
The article provides a comparative assessment of two experimental samples of the seven-component vaccine KOMBOVAС-A, manufactured with adjuvants ISA 61 and ISA 50, in terms of: antigenic activity (in laboratory and naturally susceptible animals); influence on the formation of colostral immunity in calves when vaccinating pregnant cows, as well as effectiveness in livestock farming conditions unfavorable for the main respiratory and intestinal diseases of calves of viral etiology. It was found that the vaccine sample based on the ISA 61 adjuvant had a higher antigenic activity compared to a similar sample based on the ISA 50 adjuvant, inducing a higher level of synthesis of post-vaccination antibodies. The use of the vaccine in conditions of a dysfunctional livestock farm has reduced the morbidity and mortality of calves, while the vaccine sample made on the basis of ISA 61 oil proved to be more effective.
About the Authors
E. V. Shemelkov
LLC «Vetbiohim»
Russian Federation
Russian Federation
Evgeny Vladimirovich Shemelkov, Candidate of Veterinary Sciences, Deputy Director for Production and Innovation
42 Volgogradsky Prospekt, Moscow, 109316
G. O. Shemelkova
LLC «Vetbiohim»
Russian Federation
Russian Federation
Galina Olegovna Shemelkova, Candidate of Biology Sciences, Senior Microbiologist of the Quality Control Department
42 Volgogradsky Prospekt, Moscow, 109316
E. V. Ivanov
LLC «Vetbiohim»
Russian Federation
Russian Federation
Evgeny Valerievich Ivanov, Candidate of Biology Sciences, Leading Researcher
42 Volgogradsky Prospekt, Moscow, 109316
A. D. Bulgakov
LLC «Vetbiohim»
Russian Federation
Russian Federation
Alexander Dmitrievich Bulgakov, Candidate of Veterinary Sciences, Head of Department
42 Volgogradsky Prospekt, Moscow, 109316
O. A. Verkhovsky
LLC «Vetbiohim»
Russian Federation
Russian Federation
Oleg Anatolyevich Verkhovsky, Doctor of Biological Sciences, Professor, Head of the Department of Scientific Research
42 Volgogradsky Prospekt, Moscow, 109316
T. I. Aliper
LLC «Vetbiohim»
Russian Federation
Russian Federation
Taras Ivanovich Aliper, Doctor of Biological Sciences, Professor, Chairman of the Board of Directors
42 Volgogradsky Prospekt, Moscow, 109316
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Review
For citations:
Shemelkov E.V., Shemelkova G.O., Ivanov E.V., Bulgakov A.D., Verkhovsky O.A., Aliper T.I. The influence of adjuvants ISA 61 and ISA 50 on the antigenic activity, the ability to form colostral immunity and the effectiveness of experimental samples of the vaccine KOMBOVAC-A. Agrarian science. 2024;(6):44-49. (In Russ.) https://doi.org/10.32634/0869-8155-2024-383-6-44-49
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