Identification of genes associated with color characteristics of meat and fat tissue of aberdeen-angus cattle
https://doi.org/10.32634/0869-8155-2024-383-6-68-76
Abstract
Currently, full genome association studies and identification of candidate genes for economically useful traits in farm animals are topical, scientifically sound and practice-oriented, and fulfill one of the objectives of the Strategy for Scientific and Technical Development of the Russian Federation. This article presents the results of GWAS on color spectral values of meat and fat tissue of Aberdeen-Angus cattle, known for its meat characteristics of high grade. The animals were genotyped on high-density BovineHD Genotyping BeadChip chips containing ≈53,000 SNPs. After quality control, 39,928 remained. By analysis and structural annotation, 25 and 26 candidate genes for meat and fat color were identified, respectively. According to functional annotation, the genes were categorized into 6 groups: nervous system functions, organ development, vascular, joints, metabolic processes and biosynthesis, cellular processes, muscle, tissue and bone, reproduction and embryonic development. The obtained genes were checked through the Animal QTL database, as a result of which 13 genes were confirmed, of which 3 were localized SNPs, in connection with which the LRP2, SCIN and ANTXR1 genes have advantages for their further application in the molecular diagnostics of cattle not only meat, but also dairy productivity.
Keywords
GWAS,
meat and fat color characteristics,
structural annotation of genes,
functional annotation of genes,
QTL base,
beef cattle
Supporting agencies: The research was carried out with the support of the Ministry of Science and Higher Education of the Russian Federation (registration № FGGN-2022-0011 topics of the state assignment).
About the Authors
A. A. Belous
L.K. Ernst Federal Research Center for Animal Husbandry
Russian Federation
Russian Federation
Anna Alexandrovna Belous, Candidate of Biological Sciences, Docent
60 Dubrovitsy, Podolsk Municipal District, Moscow Region, 142132
A. A. Sermyagin
L.K. Ernst Federal Research Center for Animal Husbandry
Russian Federation
Russian Federation
Alexander Alexandrovich Sermyagin, Candidate of Agricultural Sciences, Head of the Department of Population Genetics and Genetic Basis of Animal Breeding
60 Dubrovitsy, Podolsk Municipal District, Moscow Region, 142132
N. P. Elatkin
LLC «Miratorg-Genetika»
Russian Federation
Russian Federation
Nikolay Pavlovich Elatkin, Candidate of Biological Sciences, General Manager
5 Nobel Street, 2 floor, 7 room, 3 room, territory of the Skolkovo Innovation Center, Moscow, 121205
N. A. Zinovieva
L.K. Ernst Federal Research Center for Animal Husbandry
Russian Federation
Russian Federation
Nataliya Anatolyevna Zinovieva, Doctor of Biological Sciences, Russian Academy of Sciences Academy Member, Professor, Director
60 Dubrovitsy, Podolsk Municipal District, Moscow Region, 142132
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Review
For citations:
Belous A.A., Sermyagin A.A., Elatkin N.P., Zinovieva N.A. Identification of genes associated with color characteristics of meat and fat tissue of aberdeen-angus cattle. Agrarian science. 2024;(6):68-76. (In Russ.) https://doi.org/10.32634/0869-8155-2024-383-6-68-76
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