Effects of experimental infection with Trichinella spiralis larvae and Trichinella products on embryonic development of rats

Relevance. The aim of the research is to study the effect of experimental infection of T. spiralis and trichinella products on the embryonic development of rats.

Methods. The experiment was conducted on 3 experimental groups of rats with corresponding controls. The effect of chronic trichinella invasion of various durations (40–60 days and 6–8 months) on the embryonic development of rats was studied in rats of groups 1 and 2. The effect of T. spiralis protein extract on the embryonic development of fetuses from rats, which were intraperitoneally injected with the test product during the critical periods of embryogenesis (4th, 11th and 16th days), was studied on animals of the 3rd group.

Results. The negative effects of Trichinella infection on development of fetuses were detected only in rats on 40–60 days post infection. A statistically significant increase in average number of resorptions, postimplantation and total embryonic mortality were noted. The preimplantation mortality rates did not differ from the control value. Three fetuses with malformations as edema were detected. However, there were no internal anomalies. When assessing the development of fetuses from rats with Trichinella chronic infection with longer duration (6–8 months) the fetus death rates were comparable to the control ones. No fetuses with external or internal malformations were detected.

The tested protein preparation did not show negative effects on the development of embryos. In all variants of the experiment no pathology of skeletal system rudiments was noted.

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