Cytoarchitectonics and morphofunctional parameters of dermal mastocytomas in the area of the facial skeleton in dogs
https://doi.org/10.32634/0869-8155-2025-390-01-50-56
Abstract
The results of the analysis of the prevalence of primary spontaneous dermal mast cell tumors in dogs in the facial skeleton area study was conducted in 2021–2024. The object of the study were 63 dogs with primary spontaneous dermal mast cell tumors, confirmed histologically.
The purpose of the work is to study the morphofunctional indicators of dermal mast cell tumors in the facial skeleton area in dogs and to assess their degree of malignancy.
During the study, the degree of malignancy was determined according to two generally accepted classifications, according to Kupel and Patnaik — an important prognostic criterion for assessing primary spontaneous mast cell tumors in the facial skeleton area in dogs.
According to the results of histological examination of primary spontaneous mast cell tumors in the facial skeleton area in dogs according to the Kupel classification, it was revealed that less aggressive tumors are more common and account for 65.08%, while highly aggressive mast cell tumors occur in 34.92% of cases according to our data, while according to the Patnaik classification, highly differentiated mast cell tumors were detected in 20.63% of cases, moderately differentiated were observed in 49.21% of cases, and poorly differentiated — in 30.16% of cases. From the obtained information on the classification of dermal mast cell tumors, it follows that the majority of moderately differentiated mast cell tumors according to Patnaik (G2) are highly differentiated according to Kupel (G1), which affects the prognostic assessment and choice of treatment tactics for sick dogs.
Supporting agencies: The research was carried out with the support of the Ministry of Science and Higher Education of the Russian Federation (registration No. FSMF-2022-0003 topics of the state assignment).
About the Authors
Ju. N. Melikova
Russian Biotechnological University
Russian Federation
Russian Federation
Julia Nikolaevna Melikova, Candidate of Veterinary Sciences, Associate Professor of the Department of Diseases of Small Domestic, Laboratory and Exotic Animals
11 Volokolamskoye highway, Moscow, 125080
A. V. Chechneva
Russian Biotechnological University
Russian Federation
Russian Federation
Anastasia Vyacheslavovna Chechneva, Candidate of Veterinary Sciences, Associate Professor of the Department of Diseases of Small Domestic, Laboratory and Exotic Animals
11 Volokolamskoye highway, Moscow, 125080
L. A. Vernitskaya
Russian Biotechnological University
Russian Federation
Russian Federation
Liudmila Andreevna Vernitskaya, Postgraduate Student of the Department of Diseases of Small Domestic, Laboratory and Exotic Animals
11 Volokolamskoye highway, Moscow, 125080
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Review
For citations:
Melikova J.N., Chechneva A.V., Vernitskaya L.A. Cytoarchitectonics and morphofunctional parameters of dermal mastocytomas in the area of the facial skeleton in dogs. Agrarian science. 2025;1(1):50-56. (In Russ.) https://doi.org/10.32634/0869-8155-2025-390-01-50-56
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