Vaccination activity against avian influenza subtype H9 and Newcastle disease during immunization of egg-laying chickens
https://doi.org/10.32634/0869-8155-2025-393-04-34-39
Abstract
Relevance. The basis of protection against clinical expression of avian influenza subtype H9 (hereafter referred to as H9) is the level of immunity to this infection. The consequences of post-infection immunity do not exclude a decrease in production performance. It is therefore a priority to ensure post-vaccination immunity in birds. In the pathology of birds, the relationship between the epizootic situation of Newcastle disease (hereinafter — ND) and AI (H9) is important. Significant differences in the development of post-vaccination immunity against AI (H9) in replacement chickens may be due to the vaccines used in farms.
The aim of the work is to compare the effectiveness of both monovaccines against HP (H9) and bivalent vaccines against this infection and NB, taking into account the differences in adjuvants in these drugs.
Methods. Four experimental (20 heads each) and one control (10 heads each) group of chickens were formed for research. The experiment used birds that are not immune to HP (H9). In the experimental groups, chickens were vaccinated with inactivated vaccines at the age of 30 days. followed by their revaccination with a monthly interval. Blood serum sampling was performed every two weeks from the moment of initial immunization of chickens. The assessment of the level of immunity tension against GP (H9) and NB was carried out when RTGA was administered with specific antigens.
Results. The dependence of the intensity and level of post-vaccination immunity on the difference in valence of the vaccines and adjuvants used was established. The use of monovaccines against AI (H9) did not provide a fundamental advantage over the use of bivalent vaccines against AI (H9) and ND, taking into account the adjuvants used.
About the Authors
A. V. Frolov
Scientific-production enterprise «AVIVAC» ; Federal Scientific Centre VIEV
Russian Federation
Russian Federation
Alexey Viktorovich Frolov, Leading Specialist
21A Orlinskaya zone, Gorbunki, Lomonosov district, Leningrad region, 188502
24/1 Ryazansky prospect, Moscow, 109428
A. V. Ruzina
Scientific-production enterprise «AVIVAC» ; Federal Scientific Centre VIEV
Russian Federation
Russian Federation
Anna Vladimirovna Ruzina, Deputy Director of the Central Branch
21A Orlinskaya zone, Gorbunki, Lomonosov district, Leningrad region, 188502
24/1 Ryazansky prospect, Moscow, 109428
N. V. Vasyukov
Scientific-production enterprise «AVIVAC» ; Federal Scientific Centre VIEV
Russian Federation
Russian Federation
Nikolay Vadimovich Vasyukov, Leading Specialist
21A Orlinskaya zone, Gorbunki, Lomonosov district, Leningrad region, 188502
24/1 Ryazansky prospect, Moscow, 109428
T. N. Rozhdestvenskaya
Scientific-production enterprise «AVIVAC» ; Federal Scientific Centre VIEV
Russian Federation
Russian Federation
Tatiana Nikolaevna Rozhdestvenskaya, Doctor of Veterinary Sciences Director of Science; Head of the Laboratory of Avian Diseases
21A Orlinskaya zone, Gorbunki, Lomonosov district, Leningrad region, 188502
24/1 Ryazansky prospect, Moscow, 109428
References
1. Lupiani B., Reddy S.M. The history of avian influenza. Comparative Immunology, Microbiology and Infectious Diseases. 2009; 32(4): 311-323. https://doi.org/10.1016/j.cimid.2008.01.004
2. Varkentin A.V., Volkov M.S., Irza VN. Low pathogenic avian influenza induced with subtype H9 virus. Review of published literature. Proceedings of the Federal Centre for Animal Health Protection. 2014; 12: 41-53 (in Russian). https://elibrary.ru/sysydr
3. Marchenko V.Yu., Sharshov K.A., Shestopalov A.M. Ecology of influenza virus in wild bird populations in Central Asia. Bulletin of Eastern-Siberian scientific center. 2012; (5-1): 271-275 (in Russian). https://elibrary.ru/piwebj
4. Volkov M. High and low pathogenic avian flu. Animal Husbandry of Russia. 2021; (S3): 50-54 (in Russian). https://elibrary.ru/jktony
5. Volkov M.S., Varkentin A.V., Irza V.N. Spread of low pathogenic avian influenza А/Н9^ in the world and Russian Federation. Challenges of disease eradication. Veterinary Science Today. 2019; (3): 51-56. https://doi.org/10.29326/2304-196X-2019-3-30-51-56
6. Homme P.J., Easterday B.C. Avian influenza virus infections. I. Characteristics of influenza A-turkey-Wisconsin-1966 virus. Avian Diseases. 1970; 14(1): 66-74. https://doi.org/10.2307/1588557
7. Alexander D.J., Allan W.H., Parsons G. Characterization of influenza viruses isolated from turkeys in Great Britain during 1963-1977. Research in Veterinary Science. 1979; 26(1): 17-20. https://doi.org/10.1016/S0034-5288(20)30934-6
8. Alexander D.J. Summary of Avian Influenza Activity in Europe, Asia, Africa, and Australasia, 2002-2006. Avian Diseases. 2007; 51(S1): 161-166. https://doi.org/10.1637/7602-041306R.1
9. Senne D.A. Avian influenza in North and South America, 2002-2005. Avian Diseases. 2007; 51(S1): 167-173. https://doi.org/10.1637/7621-042606R1.1
10. Wright P.F., Neumann G., Kawaoka Y Orthomyxoviruses. D.M. Knipe et al. (eds.). Fields Virology. Sixth ed. Philadelphia, PA, USA: Lippincott Williams & Wilkins. 2013; 1: 1186-1243.
11. Zhou J.-P. et al. Epidemiological survey and genetic evolution of H9 subtype influenza viruses in Shanghai, China, from 2006 to 2010. Archives of Virology. 2012; 157(6): 1193-1198. https://doi.org/10.1007/s00705-012-1266-2
12. Guan Y, Shortridge K.F., Krauss S., Webster R.G. Molecular characterization of H9N2 influenza viruses: Were they the donors of the “internal” genes of H5N1 viruses in Hong Kong?. Proceedings of the National Academy of Sciences. 1999; 96(16): 9363-9367. https://doi.org/10.1073/pnas.96.16.9363
13. Frolov A.V., Pankratov S.V., Rozhdestvenskaya T.N., Norkina S.N., Shestopalov A.M. Avian influenza. Specific prevention. Veterinaria i kormlenie. 2020; (7): 64-66 (in Russian). https://doi.org/10.30917/ATT-VK-1814-9588-2020-7-17
14. Kostina L.V., Zaberezhny A.D., Grebennikova T.V., Antipova N.V., Aliper T.I., Nepoklonov E.A. Vaccines against avian influenza in poultry. Problems of Virology. 2017; 62(2): 53-60 (in Russian). https://doi.org/10.18821/0507-4088-2017-62-2-53-60
15. Shulgin V.V., Khoshafyan L.S., Anosov D.E. Evolution of Low Pathogenic Avian Influenza (H9) Vaccine Selection in Industrial Poultry Farming. Agrarian science. 2024; (12): 22-24 (in Russian). https://elibrary.ru/igyhjj
Review
For citations:
Frolov A.V., Ruzina A.V., Vasyukov N.V., Rozhdestvenskaya T.N. Vaccination activity against avian influenza subtype H9 and Newcastle disease during immunization of egg-laying chickens. Agrarian science. 2025;1(4):34-39. (In Russ.) https://doi.org/10.32634/0869-8155-2025-393-04-34-39
Views:
89
Email this article 