Molecular genetic and epigenetic mechanisms of regulation of meat productivity in chickens: recent findings on epigenetic, metabolic and breed features
https://doi.org/10.32634/0869-8155-2025-399-10-142-158
Abstract
The contemporary poultry production industry is confronted with the imperative to enhance meat productivity, a goal that necessitates a comprehensive grasp of the molecular, genetic, and epigenetic mechanisms governing growth regulation. This review analyzes current data on molecular genetic and epigenetic mechanisms regulating meat production in chickens. The study places particular emphasis on key genes (GHR, MSTN, GNPDA2, LDB2, KPNA3), exploring their roles in muscle tissue development, metabolism, and the influence of environmental factors. The results of transcriptomic studies demonstrating differences in gene expression between commercial broilers and local breeds, as well as the role of epigenetic modifications in adaptation to stressful conditions and nutrition, are summarized. The present study demonstrates that selection for accelerated growth is associated with the activation of anabolic pathways (IGF-1, PI3K/Akt), yet concomitantly increases the risk of developing muscular myopathies. As shown, the expression profiles observed in the pectoral and leg muscles, as well as in the hypothalamus, indicate the tissue-specific nature of growth regulation. The review emphasizes the necessity of considering genetic diversity and epigenetic plasticity in breeding programs and the potential of multi-omics approaches to enhance the efficiency of poultry production. The data reviewed here provide a basis for developing innovative strategies to optimize growth, meat quality, and bird adaptation to changing environmental conditions. Such strategies may include an in-depth study of gene interactions, the development of marker-assisted breeding programs, and the application of nutriepigenomics. This paper examines the molecular genetic and epigenetic mechanisms regulating meat productivity in chickens, focusing on current data concerning epigenetic, metabolic, and breed-specific factors.
Keywords
meat yield of poultry,
genetic regulation of growth,
epigenetic factors,
gene expression,
local and commercial chicken breeds
Supporting agencies: This research was funded by the Ministry of Science and Higher Education of the Russian Federation (No. Research and Development Programme 124020200114-7).
About the Authors
A. P. Dysin
Russian Research Institute of Farm Animal Genetics and Breeding — Branch of L.K. Ernst Federal Research Center for Animal Husbandry
Russian Federation
Russian Federation
Artyom Pavlovich Dysin - Junior Researcher,
55А Moskovskoe highway, Pushkin, St. Petersburg, 196625
O. Yu. Barkova
Russian Research Institute of Farm Animal Genetics and Breeding — Branch of L.K. Ernst Federal Research Center for Animal Husbandry
Russian Federation
Russian Federation
Olga Yurievna Barkova - Candidate of Biological Sciences, Senior Researcher,
55А Moskovskoe highway, Pushkin, St. Petersburg, 196625
References
1. Bist R.B. et al. Sustainable poultry farming practices: a critical review of current strategies and future prospects. Poultry Science. 2024; 103(12): 104295. https://doi.org/10.1016/j.psj.2024.104295
2. Yin Zh. et al. Cecal Microbial Succession and Its Apparent Association with Nutrient Metabolism in Broiler Chickens. mSphere. 2023; 8(3): e00614–е00622. https://doi.org/10.1128/msphere.00614-22
3. Vyayzenen G.N. et al. Biotechnical methods for increasing productivity and blood biochemical parameters of broiler chickens of the Ross 508 cross. Agrarian Science. 2022; 356(2): 47–53 (in Russian). https://doi.org/10.32634/0869-8155-2022-356-2-47-53
4. Topuria L.Yu., Topuria G.M. Digestibility of feed nutrients and metabolic status in ducklings using “Immunoflor”. Agrarian science. 2025; (2): 67–72 (in Russian). https://doi.org/10.32634/0869-8155-2025-391-02-67-72
5. Neverova O.P. et al. Influence of a biotechnological additive on the weight growth of broiler chickens. Agrarian science. 2023; (11): 70–75 (in Russian). https://doi.org/10.32634/0869-8155-2023-376-11-70-75
6. Fedorova Z.L., Vakhrameev A.B., Makarova A.V. The prospect of using chicken breeds of the combined type of productivity in organic poultry farming. Agrarian science. 2022; (12): 51–56 (in Russian). https://doi.org/10.32634/0869-8155-2022-365-12-51-56
7. Kolesnik E.A., Derkho M.A., Rebezov M.B., Mamylina N.V. Atherogenicity index, lipoprotein ratio, total cholesterol and protein of broiler chickens as a factor in health-saving technologies. Agrarian Bulletin of the Urals. 2024; 24(1): 1459‒1475 (in Russian). https://doi.org/10.32417/1997-4868-2024-24-11-1459-1475
8. Bagno O.A., Prokhorov O.N., Fedotov S.S., Rassolov S.N., Schmidt A.А. Efficiency of the use of extruded fir flour in feeding broiler chickens. Agrarian science. 2023; (11): 76–81 (in Russian). https://doi.org/10.32634/0869-8155-2023-376-11-76-81
9. Kolesnik E.A., Derkho M.A., Rebezov M.B. Atherogenicity index, “good” lipoproteins and the ratio of total cholesterol and protein of broiler chickens in the health system. Journal of Osh State University. Agriculture: Agronomy, Veterinary and Zootechnics. 2024; 4(9): 28–35. https://doi.org/10.52754/16948696_2024_4(9)_5
10. David S.-A., Mersch M., Foissac S., Collin A., Pitel F., Coustham V. Genome-Wide Epigenetic Studies in Chicken: A Review. Epigenomes. 2017; 1(3): 20. https://doi.org/10.3390/epigenomes1030020
11. Melnikov N.P. et al. Origin, genetics and evolutionary features of the genome of farm chickens. Scientific review. Biological sciences. 2024; (1): 71–78 (in Russian). https://doi.org/10.17513/srbs.1357.
12. Khvostyk V.P., Bondarenko Yu.V. Growth intensity of meat-laying chickens of different genetic origin. Bulletin of Sumy National Agrarian University. Series: Livestock. 2021; 3(46): 91–94 (in Ukrainian). https://doi.org/10.32845/bsnau.lvst.2021.3.12
13. Rotova A.Yu., Bagno O.A. Study of gene expression in assessing the influence of various factors in poultry farming. Current scientific and technical means and agricultural problems: Proceedings of the XI National scientific and practical conference with international participation. Kemerovo: Kuzbass State Agrarian University named after V.N. Poletskov. 2023; 144–147 (in Russian). https://elibrary.ru/pnhura
14. Yildirim E.A. et al. The effect of various forms of lysine and methionine in the broiler diet on the transcription profile of key genes. Agrarian science. 2025; 391(02): 87–94 (in Russian). https://doi.org/10.32634/0869-8155-2025-391-02-87-94
15. Titov V.Yu. et al. Genetic markers of meat productivity of poultry. Molecular genetic technologies for the analysis of gene expression of productivity and resistance to animal diseases: Proceedings of the 2nd International Scientific and Practical Conference. Moscow: Agricultural technologies. 2020; 136–150 (in Russian). https://elibrary.ru/kbcbhm.
16. Yildirim E.A. et al. Gene expression in farm poultry under the influence of T-2 toxin and the use of biological preparations. Acta biomedical scientifica. 2022; 7(3): 180–189 (in Russian). https://doi.org/10.29413/ABS.2022-7.3.19
17. Kim J.W. The Endocrine Regulation of Chicken Growth. Asian-Australasian Journal of Animal Sciences. 2010; 23(12): 1668–1676. https://doi.org/10.5713/ajas.2010.10329
18. Bhattacharya T.K., Chatterjee R.N. Polymorphism of the myostatin gene and its association with growth traits in chicken. Poultry Science. 2013; 92(4): 910–915. https://doi.org/10.3382/ps.2012-02736
19. Ouyang H. et al. Identification, expression and variation of the GNPDA2 gene, and its association with body weight and fatness traits in chicken. PeerJ. 2016; 4: e2129. https://doi.org/10.7717/peerj.2129
20. Wei C. et al. Molecular characterization and a duplicated 31- bp indel within the LDB2 gene and its associations with production performance in chickens. Gene. 2020; 761: 145046. https://doi.org/10.1016/j.gene.2020.145046
21. Hull K.L., Fraser R.A., Marsh J.A., Harvey S. Growth hormone receptor gene expression in sex-linked dwarf Leghorn chickens: evidence against a gene deletion. Journal of Endocrinology. 1993; 137(1): 91–98. https://doi.org/10.1677/joe.0.1370091
22. Khaerunnisa I., Jakaria J., Arief I.I., Budiman C., Sumantri C. The Associations of GH and GHR Genes with Carcass Components in Indonesian Kampung and Broiler Chicken Cross. Media Peternakan. 2017; 40(2): 78–87. https://doi.org/10.5398/medpet.2017.40.2.78
23. Xu H.D. et al. Roles of chicken growth hormone receptor antisense transcript in chicken muscle development and myoblast differentiation. Poultry Science. 2019; 98(12): 6980–6988. https://doi.org/10.3382/ps/pez416
24. Yenice E., Çenesiz A.A., Yavaş İ., Toprak N.N., Çiftci İ., Ceylan N. An investigation of the assumed efficacy of methionine hydroxy analogue compared to DL-methionine by measuring growth performance, carcass traits, and GHR and IGF-I expression in broilers. Italian Journal of Animal Science. 2023; 22(1): 1083–1094. https://doi.org/10.1080/1828051X.2023.2271056
25. Chen L. et al. Integrative Analyses of mRNA Expression Profile Reveal SOCS2 and CISH Play Important Roles in GHR Mutation-Induced Excessive Abdominal Fat Deposition in the Sex-Linked Dwarf Chicken. Front Genet. 2021; 11: 610605. https://doi.org/10.3389/fgene.2020.610605 PMID: 33519913 PMCID: PMC7841439
26. Yang C. et al. Effects of Growth-Related Genes on Body Measurement Traits in Wenshang Barred Chickens. The Journal of Poultry Science. 2022; 59(4): 323–327. https://doi.org/10.2141/jpsa.0210138
27. Kazemi H., Rezaei M., Hafezian H., Mianji G.R., Najafi M. Genetic Analysis of SNPs in GH, GHR, IGF-I and IGFBPII Genes and their Association with Some Productive and Reproductive Traits in Native Breeder Hens. Gene Technology. 2018; 7(1): 145. https://doi.org/10.4172/2329-6682.1000145
28. Fujita S., Honda K., Yamaguchi M., Fukuzo S., Saneyasu T., Kamisoyama H. Role of Insulin-like Growth Factor-1 in the Central Regulation of Feeding Behavior in Chicks. The Journal of Poultry Science. 2019; 56(4): 270–276. https://doi.org/10.2141/jpsa.0180127
29. Chen R., Zhuang S., Chen Y.P., Cheng Y.F., Wen C., Zhou Y.M. Betaine improves the growth performance and muscle growth of partridge shank broiler chickens via altering myogenic gene expression and insulin-like growth factor-1 signaling pathway. Poultry Science. 2018; 97(12): 4297–4305. https://doi.org/10.3382/ps/pey303
30. Wen C., Jiang X., Ding L., Wang T., Zhou Y. Effects of dietary methionine on breast muscle growth, myogenic gene expression and IGF-I signaling in fast- and slow-growing broilers. Scientific Reports. 2017; 7: 1924. https://doi.org/10.1038/s41598-017-02142-z
31. Salehizadeh M., Modarressi M.H., Mousavi S.N., Ebrahimi M.T. Effects of probiotic lactic acid bacteria on growth performance, carcass characteristics, hematological indices, humoral immunity, and IGF-I gene expression in broiler chicken. Tropical Animal Health and Production. 2019; 51(8): 2279–2286. https://doi.org/10.1007/s11250-019-01935-w
32. Sinpru P. et al. Association of growth hormone and insulin-like growth factor I genotype with body weight, dominance of body weight, and mRNA expression in Korat slow-growing chickens. Animal Bioscience. 2021; 34(12): 1886‒1894. https://doi.org/10.5713/ab.20.0729
33. Hosnedlova B. et al. Associations Between IGF1, IGFBP2 and TGFß3 Genes Polymorphisms and Growth Performance of Broiler Chicken Lines. Animals. 2020; 10(5): 800. https://doi.org/10.3390/ani10050800
34. Guo Y. et al. Evolutionary analysis and functional characterization reveal the role of the insulin-like growth factor system in a diversified selection of chickens (Gallus gallus). Poultry Science. 2023; 102(3): 102411. https://doi.org/10.1016/j.psj.2022.102411
35. El-Attrouny M.M., Iraqi M.M., Sabike I.I., Abdelatty A.M., Moustafa M.M., Badr O.A. Comparative evaluation of growth performance, carcass characteristics and timed series gene expression profile of GH and IGF-1 in two Egyptian indigenous chicken breeds versus Rhode Island Red. Journal of Animal Breeding and Genetics. 2021; 138(4): 463–473. https://doi.org/10.1111/jbg.12517
36. Nurcahya H., Sinaga E., Darwati S., Khaerunissa I. Relationship between of Insuline Like growth Factor-2 Gene and Growth Traits in Crosses of Indonesian Local Chicken. Journal of Physics: Conference Series. 2020; 1665: 012015. https://doi.org/10.1088/1742-6596/1665/1/012015
37. Yu M. et al. Insulin-like growth factor-1 (IGF-1) promotes myoblast proliferation and skeletal muscle growth of embryonic chickens via the PI3K/Akt signalling pathway. Cell Biology International. 2015; 39(8): 910–922. https://doi.org/10.1002/cbin.10466
38. Saneyasu T. et al. The IGF-1/Akt/S6 Signaling Pathway is Age-Dependently Downregulated in the Chicken Breast Muscle. The Journal of Poultry Science. 2016; 53(3): 213–219. https://doi.org/10.2141/jpsa.0150171
39. Abdalla B.A., Chen J., Nie Q., Zhang X. Genomic Insights Into the Multiple Factors Controlling Abdominal Fat Deposition in a Chicken Model. Frontiers in Genetics. 2018; 9: 262. https://doi.org/10.3389/fgene.2018.00262
40. McPherron A.C., Lee S.-J. Double muscling in cattle due to mutations in the myostatin gene. Proceedings of the National Academy of Sciences. 1997; 94(23): 12457–12461. https://doi.org/10.1073/pnas.94.23.12457
41. Kambadur R., Sharma M., Smith T.P.L., Bass J.J. Mutations in myostatin (GDF8) in Double-Muscled Belgian Blueand PiedmonteseCattle. Genome Research. 1997; 7(9): 910–915. https://doi.org/10.1101/gr.7.9.910
42. Kim D.-H. et al. Differential Expression of MSTN Isoforms in Muscle between Broiler and Layer Chickens. Animals. 2022; 12(5): 539. https://doi.org/10.3390/ani12050539
43. Lee J., Kim D.-H., Lee K. Myostatin gene role in regulating traits of poultry species for potential industrial applications. Journal of Animal Science and Biotechnology. 2024; 15: 82. https://doi.org/10.1186/s40104-024-01040-5
44. Xu K. et al. Transcriptomic Analysis of MSTN Knockout in the Early Differentiation of Chicken Fetal Myoblasts. Genes. 2022; 13(1): 58. https://doi.org/10.3390/genes13010058
45. Ren T., Xu M., Lin W., Luo W., Zhang X. Transcriptome sequencing reveals the potential mechanisms of dietary lutein regulation on chicken leg muscle development. Poultry Science. 2024; 103(12): 104265. https://doi.org/10.1016/j.psj.2024.104265
46. Yousefi K., Allymehr M., Talebi A., Tukmechi A. A comparative study on the expression of myogenic genes and their effects on performance and meat quality in broiler chicken strains. Veterinary Research Forum. 2024; 15(5): 243–250. https://doi.org/10.30466/vrf.2024.2014542.4046
47. Kumaravel V., Mohan B., Natarajan A., Murali N., Selvaraj P., Vasanthakumar P. Effect on growth performance, carcass traits, and myostatin gene expression in Aseel chicken fed varied levels of dietary protein in isocaloric energy diets. Tropical Animal Health and Production. 2023; 55(2): 82. https://doi.org/10.1007/s11250-023-03505-7
48. Malila Y. et al. Differential expression patterns of genes associated with metabolisms, muscle growth and repair in Pectoralis major muscles of fast- and medium-growing chickens. PLoS ONE. 2022; 17(10): e0275160. https://doi.org/10.1371/journal.pone.0275160
49. Mukhopadhyay M. et al. Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. Development. 2003; 130(3): 495–505. https://doi.org/10.1242/dev.00225
50. Yasuoka Y., Kobayashi M., Kurokawa D., Akasaka K., Saiga H., Taira M. Evolutionary origins of blastoporal expression and organizer activity of the vertebrate gastrula organizer gene lhx1 and its ancient metazoan paralog lhx3. Development. 2009; 136(12): 2005–2014. https://doi.org/10.1242/dev.028530
51. Wei C. et al. Divergent Regulatory Roles of Transcriptional Variants of the Chicken LDB3 Gene in Muscle Shaping. Journal of Agricultural and Food Chemistry. 2024; 72(21): 12240–12250. https://doi.org/10.1021/acs.jafc.4c00520
52. Guerrero-Bosagna C., Skinner M.K. Environmentally induced epigenetic transgenerational inheritance of phenotype and disease. Molecular and Cellular Endocrinology. 2012; 354(1–2): 3–8. https://doi.org/10.1016/j.mce.2011.10.004
53. Dunislawska A., Slawinska A., Siwek M. Hepatic DNA Methylation in Response to Early Stimulation of Microbiota with Lactobacillus Synbiotics in Broiler Chickens. Genes. 2020; 11(5): 579. https://doi.org/10.3390/genes11050579
54. Sikorska M., Siwek M., Slawinska A., Dunislawska A. miRNA Profiling in the Chicken Liver under the Influence of Early Microbiota Stimulation with Probiotic, Prebiotic, and Synbiotic. Genes. 2021; 12(5): 685. https://doi.org/10.3390/genes12050685
55. Dunislawska A., Gryzinska M., Siwek M. Changes in the gene expression and methylation in chicken cecal tonsils after in ovo administration of bioactive substances. Scientific Reports. 2023; 13: 19840. https://doi.org/10.1038/s41598-023-47080-1
56. Ibrahim M., Bednarczyk M., Stadnicka K., Grochowska E. Interand Transgenerational Effects of In Ovo Stimulation with Bioactive Compounds on Cecal Tonsils and Cecal Mucosa Transcriptomes in a Chicken Model. International Journal of Molecular Sciences. 2025; 26(3): 1174. https://doi.org/10.3390/ijms26031174
57. Alagawany M. et al. Betaine and related compounds: Chemistry, metabolism and role in mitigating heat stress in poultry. Journal of Thermal Biology. 2022; 104: 103168. https://doi.org/10.1016/j.jtherbio.2021.103168
58. Yu B. et al. Identification of key differentially methylated genes in regulating muscle development and intramuscular fat deposition in chickens. International Journal of Biological Macromolecules. 2024; 264(2): 130737. https://doi.org/10.1016/j.ijbiomac.2024.130737
59. Florini J.R., Ewton D.Z., Coolican S.A. Growth Hormone and the Insulin-Like Growth Factor System in Myogenesis. Endocrine Reviews. 1996; 17(5): 481–517. https://doi.org/10.1210/edrv-17-5-481
60. Li R., Hu Y., Ni Y., Xia D., Grossmann R., Zhao R. Leptin stimulates hepatic activation of thyroid hormones and promotes early posthatch growth in the chicken. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 2011; 160(2): 200–206. https://doi.org/10.1016/j.cbpa.2011.06.001
61. Wu H., Xu T., Yang N., Zhang J., Xu S. Low-Se Diet Increased Mitochondrial ROS to Suppress Myoblasts Proliferation and Promote Apoptosis in Broilers via miR-365-3p/SelT Signaling Axis. Journal of Agricultural and Food Chemistry. 2024; 72(1): 284–299. https://doi.org/10.1021/acs.jafc.3c04406
62. Kong B.-W. et al. RNA sequencing for global gene expression associated with muscle growth in a single male modern broiler line compared to a foundational Barred Plymouth Rock chicken line. BMC Genomics. 2017; 18: 82. https://doi.org/10.1186/s12864-016-3471-y
63. Mohammadabadi M., Bordbar F., Jensen J., Du M., Guo W. Key Genes Regulating Skeletal Muscle Development and Growth in Farm Animals. Animals. 2021; 11(3): 835. https://doi.org/10.3390/ani11030835
64. Jawasreh K., Al Athamneh S., Al-Zghoul M.B., Al Amareen A., Al Sukhni I., Aad P. Evaluation of growth performance and muscle marker genes expression in four different broiler strains in Jordan. Italian Journal of Animal Science. 2019; 18(1): 766–776. https://doi.org/10.1080/1828051X.2019.1573647
65. Lassiter K., Kong B.C., Piekarski-Welsher A., Dridi S., Bottje W.G. Gene Expression Essential for Myostatin Signaling and Skeletal Muscle Development Is Associated With Divergent Feed Efficiency in Pedigree Male Broilers. Frontiers in Physiology. 2019; 10: 126. https://doi.org/10.3389/fphys.2019.00126
66. Yalcin S., Ozkan S., Acar M.C., Meral O. The occurrence of deep pectoral myopathy in broilers and associated changes in breast meat quality. British Poultry Science. 2018; 59(1): 55–62. https://doi.org/10.1080/00071668.2017.1401214
67. Izadnia H.R., Tahmoorespur M., Bakhtiarizadeh M.R., Nassiri M., Esmaeilkhanien S. Gene expression profile analysis of residual feed intake for Isfahan native chickens using RNA-SEQ data. Italian Journal of Animal Science. 2019; 18(1): 246–260. https://doi.org/10.1080/1828051X.2018.1507625
68. Chen F. et al. Transcriptome Analysis of Differentially Expressed Genes Related to the Growth and Development of the Jinghai Yellow Chicken. Genes. 2019; 10(7): 539. https://doi.org/10.3390/genes10070539
69. Li Z. et al. Profiles of expression pattern and tissue distribution of host defense peptides genes in different chicken (Gallus gallus) breeds related to body weight. PLoS ONE. 2020; 15(12): e0238675. https://doi.org/10.1371/journal.pone.0238675
70. Kocamis H., McFarland D.C., Killefer J. Temporal expression of growth factor genes during myogenesis of satellite cells derived from the biceps femoris and pectoralis major muscles of the chicken. Journal of Cellular Physiology. 2001; 186(1): 146–152. https://doi.org/10.1002/1097-4652(200101)186:13.0.CO;2-Q
71. Zhang Z. et al. Small RNA sequencing of pectoral muscle tissue reveals microRNA-mediated gene modulation in chicken muscle growth. Journal of Animal Physiology and Animal Nutrition. 2020; 104(3): 867–875. https://doi.org/10.1111/jpn.13312
72. Zhang Y. et al. Transcriptome analysis of the pectoral muscles of local chickens and commercial broilers using Ribo-Zero ribonucleic acid sequencing. PLoS ONE. 2017; 12(9): e0184115. https://doi.org/10.1371/journal.pone.0184115
73. Bordini M., Soglia F., Davoli R., Zappaterra M., Petracci M., Meluzzi A. Molecular Pathways and Key Genes Associated With Breast Width and Protein Content in White Striping and Wooden Breast Chicken Pectoral Muscle. Frontiers in Physiology. 2022; 13: 936768. https://doi.org/10.3389/fphys.2022.936768
74. Mutryn M.F., Brannick E.M., Fu W., Lee W.R., Abasht B. Characterization of a novel chicken muscle disorder through differential gene expression and pathway analysis using RNAsequencing. BMC Genomics. 2015; 16: 399. https://doi.org/10.1186/s12864-015-1623-0
75. Hu Y., Su J., Cheng L., Lan D., Li D. Pectoral muscle transcriptome analyses reveal high-altitude adaptations in Tibetan chickens. Animal Biology. 2020; 70(4): 385‒400. https://doi.org/10.1163/15707563-bja10026
76. Du P. et al. FKBP5 as a key regulator of metabolic processes in birds: Insights from chicken pectoral muscle. Poultry Science. 2025; 104(1): 104657. https://doi.org/10.1016/j.psj.2024.104657
77. Torrella J.R., Fouces V., Fouces J., Viscor G. Capillarity and Fibre Types in Locomotory Muscles of Wild Yellow‐Legged Gulls (Larus cachinnans). Physiological Zoology. 1998; 71(4): 425–434. https://doi.org/10.1086/515425
78. Xue Q., Zhang G., Li T., Ling J., Zhang X., Wang J. Transcriptomic profile of leg muscle during early growth in chicken. PLoS ONE. 2017; 12(3): e0173824. https://doi.org/10.1371/journal.pone.0173824
79. Yin X., Wu Y., Zhang S., Zhang T., Zhang G., Wang J. Transcriptomic profile of leg muscle during early growth and development in Haiyang yellow chicken. Archives Animal Breeding. 2021; 64(2): 405–416. https://doi.org/10.5194/aab-64-405-2021
80. Wu P. et al. Transcriptome profile analysis of leg muscle tissues between slow- and fast-growing chickens. PLoS ONE. 2018; 13(11): e0206131. https://doi.org/10.1371/journal.pone.0206131
81. He M. et al. Transcriptome analysis of leg muscles in fast and slow growth Bian chickens. Animal Biotechnology. 2020; 31(4): 295–305. https://doi.org/10.1080/10495398.2019.1588129
82. Millington G.W.M. The role of proopiomelanocortin (POMC) neurones in feeding behaviour. Nutrition & Metabolism. 2007; 4: 18. https://doi.org/10.1186/1743-7075-4-18
83. Yuan L., Ni Y., Barth S., Wang Y., Grossmann R., Zhao R. Layer and broiler chicks exhibit similar hypothalamic expression of orexigenic neuropeptides but distinct expression of genes related to energy homeostasis and obesity. Brain Research. 2009; 1273: 18–28. https://doi.org/10.1016/j.brainres.2009.03.052
84. Piórkowska K. et al. Identification of candidate genes and regulatory factors related to growth rate through hypothalamus transcriptome analyses in broiler chickens. BMC Genomics. 2020; 21: 509. https://doi.org/10.1186/s12864-020-06884-5
85. Sun H. et al. Transcriptome responses to heat stress in hypothalamus of a meat-type chicken. Journal of Animal Science and Biotechnology. 2015; 6: 6. https://doi.org/10.1186/s40104-015-0003-6
86. Tu W.-L. et al. Profiling of differential gene expression in the hypothalamus of broiler-type Taiwan country chickens in response to acute heat stress. Theriogenology. 2016; 85(3): 483–494.e8. https://doi.org/10.1016/j.theriogenology.2015.09.028
87. Fang X.-L. et al. Differential gene expression pattern in hypothalamus of chickens during fasting-induced metabolic reprogramming: Functions of glucose and lipid metabolism in the feed intake of chickens. Poultry Science. 2014; 93(11): 2841–2854. https://doi.org/10.3382/ps.2014-04047
88. Badakhshan Y., Roudbari Z. The changes in hypothalamic mRNA transcription of genes related to behavior and feeding in incubating and laying hens: based on RNAseq Data. Journal of Epigenetics. 2024; 5(1): 32‒40. https://doi.org/10.22111/jep.2024.47868.1067
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For citations:
Dysin A.P., Barkova O.Yu. Molecular genetic and epigenetic mechanisms of regulation of meat productivity in chickens: recent findings on epigenetic, metabolic and breed features. Agrarian science. 2025;(10):142-158. (In Russ.) https://doi.org/10.32634/0869-8155-2025-399-10-142-158
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