Identification of SNPs and candidate genes associated with first egg weight in laying hens based on whole-genome genotyping data
https://doi.org/10.32634/0869-8155-2025-400-11-68-75
Abstract
The search for genetic markers and their identification that determine the formation and degree of manifestation of promising phenotypes for economically important traits in chickens is one of the priority tasks of genomic selection.
The research objectives are to search for and identify single nucleotide polymorphisms (SNPs) and candidate genes associated with the weight of the first egg in laying hens based on genome—wide genotyping data.
The object of the study was F2 hens of the resource population obtained by interbreeding two breeds with contrasting egg productivity — Russian White and Cornish (n = 94). F2 individuals were assessed by the weight of the first egg at the beginning of laying. For whole-genome genotyping of F2 hens, the Illumina Chicken 60K SNP iSelect BeadChip DNA chip was used.
Based on the obtained phenotype and genotype data, whole-genome association studies were performed. Seven significant SNPs (p < 1.06 x 10-5) associated with the first egg weight in F2 resource population hens were identified. The 26 genes were identified in the SNP data area, including 3 genes in SNP positions (MPP7, SNTG1, SEPTIN11). It was established that genotypes GG at the Gga_rs15141739 locus (SNTG1) and AA at the GGaluGA162050 locus cause a high weight of the first egg (p < 0.01).
Supporting agencies: This research was supported financially by the Ministry of Science and Higher Education of the Russian Federation (subject No. FGGN-2024-0015).
About the Authors
N. A. Volkova
L.K. Ernst Federal Research Center for Animal Husbandry
Russian Federation
Russian Federation
Natalia Alexandrovna Volkova, Doctor of Biological Sciences, Chief Researcher, Head of the Cryobiology Laboratory
60 Dubrovitsy, Podolsk Municipal District, Moscow Region,142132
A. N. Vetokh
L.K. Ernst Federal Research Center for Animal Husbandry
Russian Federation
Russian Federation
Anastasia Nikolaevna Vetokh, Reasearcher at the Cryobiology Laboratory
60 Dubrovitsy, Podolsk Municipal District, Moscow Region,142132
L. A. Volkova
L.K. Ernst Federal Research Center for Animal Husbandry
Russian Federation
Russian Federation
Ludmila Alexandrovna Volkova, Candidate of Biological Sciences, Researcher of the Microbiology Laboratory
60 Dubrovitsy, Podolsk Municipal District, Moscow Region,142132
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Review
For citations:
Volkova N.A., Vetokh A.N., Volkova L.A. Identification of SNPs and candidate genes associated with first egg weight in laying hens based on whole-genome genotyping data. Agrarian science. 2025;(11):68-75. (In Russ.) https://doi.org/10.32634/0869-8155-2025-400-11-68-75
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