Abstract
Vavilov's theory of plant immunity to harmful organisms has been recently branching out in the knowledge of the subtle mechanisms of interaction not only in the two-component system "plant-host - parasite", but also in the multidimensional metabiom - metaorganism, including, another of plant, viruses, bacteria, fungi and insects. The paper (article) discusses the participation in the protective reactions of plants as one of the components of this metaorganism - endophytic microorganisms, exhibiting, on the one hand, a direct protective effect - antibiotic, insecticidal, antiviral, and on the other - their mediated priming of resistance (immunity) in plant cells. According to the authors, the strategy for the development of new environmentally friendly drugs for plant protection should take into account the role of the mutualistic microbiome in host resistance to harmful organisms.