Determination of acute toxicity of Tiacyclin solution for injection in laboratory animals

Abstract

The article presents the results of studies on the determination of the acute toxicity division of thiacycline injection lectures on laboratory animals. The LD50 value of the drug Thiacycline Oral Injection mice males is 2698 (2248 + 3464) mg/ kg, and males exceed 10,000 mg/kg, which, in accordance with hygienic classification according to state standard 12.1.007-76 allows attributing the drug to the 3 hazard class (according to toxicological parameters for mice that have a higher sensitivity to the drug, than rats). The value of the LD50 drug thiacycline solution for injection, subcutaneous administration to male rats is 6147(3933+8202) mg/kg, which, according to the Sidorova classification (1973) attributing the drug to 6 toxicity class (relatively harmless substances).