Pharmacokinetics of azithromycin in the blood plasma of pigs was investigated following single intramuscular administration of Zitrex as a part of the preclinical studies. Zitrex, containing 100 mg/ml of azithromycin as the active substance, was administered to 6 piglets once intramuscularly in the neck area at the dose of 1 ml/20 kg, which corresponds to 5 mg/kg of azithromycin. In 1; 3; 6; 9; 12; 18; 24; 36; 48; 60; 72; 84 and 96 hours following Zitrex administration blood samples were collected and azithromycin concentrations in blood plasma were analyzed by high performance liquid chromatography using a fluorescent detection. The pharmacokinetic profile of azitromicin in blood plasma of pigs was established. The data obtained allow designating the tested substance as a «long-lived» compound.

The article presents the results of two production inspections on young cattle with an initial live weight of 73.8 kg in the summer period. and in the winter period, 71.9 kg, by feeding the two most effective doses of a natural mineral additive as part of the feed mixture. In the summer, the young cattle in the diet received30.25 mJ exchange energy and407.2g digestible protein, in winter, respectively, 30.67mJ and225.0g digestible protein. The average daily gain in the experimental group in the summer, which in the feed mixture was fed 20 g per day, the head of the natural mineral additive was 4.6% more, and in the winter period, where 30 g was added to the diet. mineral supplement was 2.59% more compared to control animals. The recoupment of additional expenses per one ruble in the summer period was 21.3 and in the winter period 8.28 rubles. The content of chemical elements in hair samples of withers, back and tail, it turned out that the content of cadmium in the summer period in all hair samples in young cattle was lower in the experimental groups who received the natural mineral supplement.

Scientific and economic experience on the effectiveness of feeding different forms and levels of selenium was carried out on suckling pigs of a large white breed, formed on the principle of analogues in three groups of 30 heads, each 60 days long. The suckling sows were together with the piglets for 28 days (before weaning the pigs) and received compound feed SK-2 according to the feeding scheme adopted at the enterprise. Suckling piglets were fed CK-3 before weaning, and CK-3 and CK-4 after the detachable (29-60 days). Piglets of the 2 nd and 3rd experimental groups received 0.15 and 0.20 mg of B-Traxim Selenium per 1 kg of compound feed. Piglets of the control group were fed in the composition of SC-3 and SC-4 inorganic selenium (sodium selenite) in an amount of 0.3 mg per 1 kg of feed, whereas the young of the 2nd and 3 experimental groups received 0.15 and 0.20 mg V-Traxim Selene. The use of growing pigs of various levels of B-Traxim Selenium as part of mixed feeds by 1 kg contributed to an increase in the average daily increase in the intensity of the increase in live weight of the young at 28 and 60 days of age, respectively 2.8; 2.4; 3.1; 2.7% and 6.2; 3.6; 14.0; 11.4% compared with control animals. The feeding of different levels of B-Traxim Selenium contributed to the reduction in the cost of ECE by 6.95-4.23%, crude protein 6.7-3.9% and feed 6.7-3.8%. Inclusion in the diet of the experimental groups of piglets of various levels of B-Traxim Selenium contributed to an increase in the digestibility of all nutrients compared to the control. The use of different levels of B-Traxim Selenium in the diets of rearing young pigs contributed to an increase in the content of morphological, biochemical, and immunological blood parameters. The greatest economic effect was obtained in the 2 nd experimental group of piglets who received 0.15 mg of B-Traxim Selenium per 1 kg of feed and amounted to 340 rubles per head.

The article presents the results of studies on the comparative characteristics of the milk productivity of the Tuvan mares bred in different ecological zones of the Republic of Tuva. It reveals the nature of the relationship between milk components and body weight with milk productivity. It was found out the milkiness superiority of the mountain zone’s mares above the steppe zone’s mares on the main indicators characterizing the animal milkiness. Also it was dicovered the different correlation between the components of milk and the average milkiness of compared animal groups, i.e from low negative till nigh positive. There is direct positive correlation between the body weight and the average milkiness of compared mares.

The article presents experimental data on the study of constitutional features and body weight of crossbred calves from birth to the beating. A comparative analysis of measurements and body build indices of young genes of different genotypes is given. The most effective crossing variant has been established, which allows improving the meat qualities of sheep bred in the republic. Lambs derived from cross-haired coarse queens of the 1st group are more knocked down and massive, they had more pronounced meat forms. The average daily weight gain in this group from birth and before beating at the Yarochek ranged from 132.3 to 183.6 g., From the rams from 172.1 to 190.0 g.

The effect of microbiological preparations Gribophyt and Imunazot on microbiological activity of typical chernozem, winter wheat straw destruction and the yield of the succeeding crop of the crop rotation, i.e. sugar beet, was studied. It is found out that the treatment of straw with a bacterial-fungi complex (Gribophyt, 7 L/ha+Imunazot, 3 L/ha) after 90 days of exposing (August-October) increased microbiological activity of the soil by 16.4 %, facilitated 30.6 % of wheat straw destruction, or by 9.8 % higher than that in the control variant. The application of the bacterial-fungi complex (Gribophyt, 7 L/ha+Imunazot, 3 L/ha) for the straw treatment, and also for two-fold treatment of sugar beet in the phase of filling rows and in the phase of filling interrow spaces (Gribophyt, 3 L/ha+Imunazot, 3 L/ha) increased sugar beet yield by 4.3 t/ha in comparison with the yield in the control variant equal to 51.6 t/ha. The application of the bacterial-fungi complex Gribophyt+Imunazot when treating winter wheat straw and two-fold sugar beet treating was economically profitable and ecologically reasonable.

This article presents the results of a study of the influence of liquid microfertilizer Izagri on the yield and grain quality of winter wheat of the Khasyr soft variety, joint selection of the Kalmyk and Krasnodar Research Institute of Agriculture, on a natural agrochemical background and on the background of the use of mineral fertilizers in a dose of N₄₄P₆₀. The results showed that the use of mineral fertilizers and Isagri liquid microfertilizers contributed to obtaining significant yield increases not only under the favorable conditions observed in the 2016-2017 agricultural year, but also against the background of the almost complete absence of precipitation. So, in 2018, in the variants using Izagri, an increase of 21-26% was obtained on the natural agrochemical background and by 31-35% on the background of the use of mineral fertilizers in the dose of N₄₄P₆₀.

The article presents the results of studies on the effectiveness of methods for creating sown grass stands on the estuarine meadows in 2013-2017. In Yakutia, zoned perennial grasses and varieties of herbs, allow you to create grasses from early-maturing grasses that can quickly grow in the spring, and withstand repeated grazing. Therefore, it is important to study the effectiveness of methods for creating sown grass stands on the estuarine meadows for the uniform supply of green fodder during the grazing period. The studies on effective methods of creating a seeded grassland in estuary meadows in Central Yakutia were conducted in the research and production station "Liman" FGBN YANIISKH state University named after M.G. Safronov. To create cereals seeded grassland used cultivars of perennial grasses: smooth brome-grass variety Amacan, Siberian wildrye variety of Nyurbinskaya, lakokraski Sitnikova variety Manchaary. Sowing was carried out in the first decade of June, the method of sowing is bloodless, ordinary with rows of 15 cm. Records and observations were carried out according to the generally accepted methods of the Institute of feed. Statistical processing of the data on the productivity was carried out by the method of dispersion analysis of the yield. The highest yield of sown grasses in hay used on estuary grassland in the conditions of the alas formed the cereal mixture from the rump (20 kg/ha) + wildrye (16 kg/ha) and 2.6 t/ha SV, which is higher than the control at 1.5 t/ha. a Based mixtures to Lyman meadows made awnless brome (90,0%) SV, introduced the types of natural herbs (8,0%) ST.

The article presents the research data on the effect of harvesting time on the productivity and feed value of the Sudanese grass in the conditions of the 1st zone of the West Kazakhstan region. The purpose and objectives of the research are to study the elements of adaptive technology of cultivation of Sudanese grass, to provide livestock with complete feed. The result of these tests the productivity and feeding value of Sudan grass depending on the time of harvesting hay mass. According to the research data, the yield and fodder value of Sudanese grass in the 1st zone of West Kazakhstan region depended on the terms of harvesting. At the same time, the highest productivity of Sudanese grass for the collection of green, dry mass and yield of feed units, protein, and exchange energy was established when harvesting the mowing mass in the flowering phase. The research results are relevant and find their practical application in the organization of modern feed production.

Studies aimed at studying the fertility indicators of the arable layer of the soil depending on the use of green manure fumes in potato cultivation were carried out in a stationary experiment (2014-2016) based on the Yakutsk Research Institute of Agriculture. Three types of sideral vapors were taken as objects of study: oats for plowing - potatoes - potatoes, sweet clover - clover for plowing-potatoes, peaoats mixture for plowing - potatoes - potatoes, potatoes for potatoes, and two layers of soil: 0-10 cm and 10-20 cm. As a control option was used in the cultivation of potatoes in monoculture. It was revealed that the inclusion of green manure crops in the crop rotation link has a positive effect on the phosphate and potash regimes of the soil. The content of humus in a layer of 0-10 cm of soil increases with the cultivation of potatoes after green manure crops, both in a layer of 0-10 cm and in a layer of 10-20 cm. When growing potatoes in a monoculture, the difference is 0.16% in a layer of 0-10 cm and 0.27% in a layer of 10-20 cm. Thus, cultivation of potatoes with the inclusion of green manure crops forms an arable layer with an upper location of the fertile horizon. In the layer of 10-20 cm, there is a decrease in the content of mobile phosphorus and exchangeable potassium and their degree of mobility, as well as the content of humic substances and the biological activity of the soil.

Manganese fertilizers increase the yield and quality of many crops in black soil conditions. As evidenced by the results of agrochemical soil survey of the arable layer of reference areas, the content of mobile manganese in the acetate-buffer solution pH 4.8 is characterized as average. However, the content of manganese in the last (studied) period (20012003, 2005-2012) has undergone significant changes. These changes differ not only in individual areas of the economy, but also depending on the geographical location (Northern or southern natural area). If the provision of manganese in the Northern region in 2012 the average was 19.0 mg/kg of soil, in the South-18.6 mg/kg. moreover, in the southern region, on average, all sites showed a decrease in content from 18.5 to 17.5 mg/kg. A significant decrease in the content of manganese in 2007, it was noted SHP "the dawn" Dolgorukovsky district, "five-year plan", terbunskiy district, respectively, and 20.4 to 10.1 and 17.2 in 14.0. However, in the Northern region from 2005 to 2012 there was an increase in Mn content by 4.0 mg/kg (from 15.0 to 19.0 mg). The structure of sown areas had a significant impact on the change of manganese content in the soils of the studied farms and areas. Thus, the sugar beet in recent years (2014-2015) in Dobrinska area was 30 024 ha, in Lebedyanskiy - 10 282, in Gryazinskiy - 7000, in Lipetsk-6 622 hectares of Sugar beet is characterized by high consumption and removal of manganese with the harvest. In a complete soil survey of the region of the CA "Lipetsk" there is a gradual decrease in manganese content (1987-2012). If in the fifth cycle of the survey was 6% of the areas with low security, 74% of the average and 20% of the high, in the tenth cycle, respectively, was: 35.1; 58.9; 6.0% of the area.

Salts in the composition of the soil, especially soluble, have a serious impact on the development of crops, can dramatically reduce their yield.The results of leaching on salty soil in Bukhara oasis with the help of chemical component Biosolvent (ChCB) and its effect on effectiveness of leaching is given in this article.As a result of the analysis, the degree of soil salinity was determined: the soil is moderately saline, refers to chloride-sulfate salinization.Washing works on the experimental field were performed on January 9-24, 2017. In the experimental field, the highest leaching rate was registered in the traditional method used in the farm, with this option the seasonal leaching rate was 3,986 cbm/ha, 2 washes were performed during the season. In the 2nd option, the washing work was carried out using ChCB, and tested in accordance with their recommendations, in which the leachingrate was reduced by 30%, which amounted to 2447 cbm/ha, while washing was performed 1 time. In option-1 of the experiment, the leaching rate was calculated according to the formula by V.R. Volobuev and amounted to 3492 cbm/ha, and this rate was fed in 2 steps.

The scientific article presents the results of a study on the influence of seed and vegetatively propagated, different in strength, growths of apple rootstocks on the nature of the development of the habitat of the aerial part and generative shoots of shoots in the crown of grafted plants. In the study, four types of low-growing vegetatively propagated and one seed stock of the Sivers apple tree, as well as regionalized varieties of the apple tree, were used as the object of the study of the rootstocks. The results of the study showed that the power of rootstocks growth has a significant impact not only on the parameters of the overall development of the aerial part of grafted varietal plants, but also on the character of the generative shoots formed in the crown, the thickness of the assimilation surface of the leaves formed, the time of plant entry into fruiting, overall productivity, size and a lot of fruits. In particular, at the age of three, the tallest varieties, as expected, turned out to be 2.7-2.8 meters grafted on the seed stock of the Sievers apple tree. The trees grown on the MIX rootstock were limited in growth - 1.9-2.2 meters. Intermediate position was occupied by varieties grafting on dusen MXII - 2.4 2.5 meters. In the development of bole the best development at the age of three, the plants grafted on the rootstock dusen MII and MIV - 3.9-5.0 cm/tree. Of the studied rootstocks and varieties of apple trees, the early deliberation of the variety was Golden Deliciously grafted on the MIX stock, which in the third year after planting provided a yield of 7.0 t/ha. The lowest yield for the years of research on this variety was obtained using seedlings of the seed stock of the Sievers apple tree.

The results of a comprehensive assessment of the varieties and hybrids of plums of domestic domestic breeding (FGBSI “North Caucasus Federal Scientific Center for Horticulture, Viticulture, Winemaking”) obtained from the directed crosses in the south of Russia are presented in the article. According to the results of the research, it was established that the taste qualities of plum fruits and the content of biochemical substances are determined by the biological characteristics of varieties, hybrids, and the conditions of the year. On the basis of a comparative analysis of the biochemical composition of fruits of different varieties and promising hybrid forms, the best domestic varieties Krasotka, Podruga, Herzog and hybrid form 17-2-64 were identified.

This scientific article presents the results of a study on the growth and development of collection varieties of currants in order to identify the most promising for cultivation in Uzbekistan. Research has shown that the control variety Uzbekistan large-fruited and Elixir differ in hardness in the development of shoots in the above-ground part. 96,5-97.5 cm. Of the tested varieties of currant, the earliest onset of the flowering phase was observed in the Herod variety - March 23; in the others, somewhat later. The late start of flowering was possessed by the Siyuma variety, in which this phase began on March 27, that is, four days later. The mass flowering phase (75%), as well as its onset, occurred most early and more intensively in the Herod variety, 10 days later in the Uzbek sweet variety. The control variant, the Uzbekistan large-fruited variety, ended this phase five days later than the Uzbek sweet variety. Of the studied collection varieties of currants, the phase of the full set of berries most intensively for 30 days, as expected, was observed in the Herod variety. In the Elixir variety, the complete set of berries ended two days later, in the rest within 34-36 days.

The article presents the results of environmental testing on the experimental field of the Federal State Scientific Institution RosNIISK “Rossorgo” of sunflower varieties and hybrids approved for use in the Russian Federation. The experiment was carried out in accordance with the plan of two-factor experiment: factor A is the variety sample, factor B is the year of testing. The study included 16 varieties. The experiments were carried out in 2015-2017. Observations, measurements and counts were performed according to generally accepted methods. The manifestation of the actual values of variety samples by the morphological features and biochemical composition of sunflower seeds is caused by the influence of the variety (A) factor, the factor of the year (B) and their interaction (AB). The grouping of variety samples into three classes was determined by the calculation of average values by experience. Then the high value was considered as a larger value of x than X + NDS, and a low value - less X- NDS. The middle class was calculated - X ± NDS. According to plant height, the contribution of factors to the total variability was: A = 57.96%, B = 22.06%, AB = 17.57%, residual = 2.41%. The variability of 1000 seeds is determined by the genotype of two variety samples: factor A - 24.91%, factor B - 50.38%, interaction of AB - 22.02%, unrecorded factors - 2.69%. The influence of factor A on seed yield was 13.83%, factor B - 54.24%, AB interaction - 28.56%, residual - 3.37%. The following samples are referred to the high-diner: Oligarch, Starbella, Bella, Jupiter, Armoni, Tutti. In the experiment it was found that under the influence of weather conditions, the biochemical composition of sunflower seeds significantly changes. The effect of factors of the oil contented in sunflower seeds was: A - 47.18%, B - 16.28%, AB interaction - 26.84%, residual - 9.70%. The influence of the protein contents differs: A-20.90%, B - 36.50%, interaction of AB - 30.61%, residual - 10.99%. More than 49.7% of the oil in the seeds was found in the following variety samples: Voronezhskiy 638, Isabella, Starbella, Bella, Continent, Fortimi, Armoni, Tutti. The protein content more than 14.10% was found in the seeds of Jupiter, Kharkiv 49.

The article proves the need of carrying out researches on the adaptability of potatoes grades in the conditions of gray forest soils in the Kaluga region. It is shown that efficiently it is possible to use a grade, only having information on its adaptive ability - the major property which accounting has to cause the greatest compliance between a genotype and environmental conditions. Development of scientifically based recommendations about perfecting of elements of technology of cultivation by a path of rational selection of the grades of potatoes combining high efficiency with ecological adaptability and resistance to adverse factors of the external environment was the purpose of researches. A method of scientific work - field experiment. Researches are conducted in 2014-2018 on the FGBNU field base "Kaluga NISH". Work is carried out according to "A technique of researches on the culture of potatoes (M., 1967). Technology of cultivation of culture - traditional with row-spacings of 70 cm. The coefficient of adaptability (KA) determined by the attitude of efficiency of a grade towards "srednesortovy efficiency of year" was carried out by L.A. Zhivotkov's technique, etc. Data on efficiency and adaptability of 25 grades of potatoes of domestic and foreign selection of early, sredneranny and mid-season groups of ripeness are provided in article. The obtained data allowed to reveal the high-yielding grades which are characterized the external environment raised by resistance to various adverse factors that finds the expression in adaptability coefficient higher than unit. On coefficient of adaptability of a grade were located in the following order: early ripe - Good luck (1.27), Kaluga (1.26), Aroza (1.02); sredneranny-the Madam (1.26), Ryabinushka (1.1), the Joy (1.08), Ilyinsky, Santa (1.02), Gala (1.0); mid-season - Kolobok (1.21), Irbitsky (1.15), the Miracle (1.02). The listed set of grades is relevant for cultivation in the conditions of gray forest the srednesuglinistykh of soils of the Kaluga region.