Relevance. The work is devoted to the results of studying of the antimicrobial and therapeutic efficacy of the drug thiacycline in subclinical mastitis in sheep. The aim of our research еsеwas to study the antimicrobial activity and therapeutic efficacy of thiacycline in subclinical mastitis in lactating ewes.

Methods. The study of antimicrobial activity was carried out by the method of serial dilutions in a liquid nutrient medium, on the basis of the Caspian zonal NIVI in the laboratory on the study of diseases of non-infectious etiology of farm animals. The therapeutic efficacy of thiacycline was studied in the SEC "Bukhti" of the Gunib district of Dagestan Republic on ewes of the Dagestan rock, aged from 3 to 5 years, with subclinical mastitis, in the amount of 51 heads. Animals on the basis of analogues were divided into two groups: experience (n = 26), control (n = 25). The animals of the experimental group were treated with thiacycline, the drug was administered intramuscularly, once a day, in dose 0.1 ml/kg. The test combination drug thiacycline developed by VIC. The control group was treated with bicillin-3, in dose 600,000 units per head, with an interval 72 hours.

Results. The complex antibacterial drug thiacycline has a wide spectrum and high antimicrobial effect against museum strains and potential causative agents of sheep mastitis. The therapeutic efficacy of thiacycline in the treatment of subclinical mastitis in sheep – 97.0%, which is on 13.0% higher compared to bicillin-3. On the 7th day after the last administratin of preparation all the physicochemical parameters of milk corresponded to the physiological norm.

Relevance. Currently, poultry farming is one of the stressful branches of agriculture, which is associated with a high intensity of both poultry growth and technological processes. In this regard, the urgent task of the industry is to optimize metabolic processes and prevent stress by introducing effective nutrients with high bioavailability into the diet.

Material and methods. The studies were carried out in the conditions of a poultry enterprise in the Central region, as well as in the vivarium and at the department of parasitology and veterinary-sanitary examination of the Federal State Budget Educational Institution of Higher Education of the Moscow State Medical Aviation and Biological Institute named after K.I. Scriabin on broilers of the cross "Cobb-500". All studies were conducted according to generally accepted methods.

Results. The use of feed additives of the Prodaktiv line allowed improving the main production indicators of broiler chickens, such as meat productivity and safety, as well as a number of other indicators in all experiments.

Relevance. Currently, the market for acaricidal drugs is very diverse. In this regard, the problem of finding effective drugs for the treatment of animal acaroses is of no small importance for practicing veterinary specialists.

Methods and results. The paper deals with the issues of comparative acaricidal efficacy of aversectin ointment and amitrazine solution in cats notothedrosis. The studies were carried out on the basis of the veterinary clinic "Doctor Zoo" in Ulyanovsk. To achieve this goal, three groups of cats with notoedrosis were formed. For the treatment of animals of the first experimental group, aversectin ointment was used. Cats of the second experimental group were treated by treating the affected areas of the skin with amitrazine solution. The third group was not treated and served as a control. In the course of the study, the authors came to the conclu-sion that the amitrazine solution has a greater acaricidal activity in cat noothedrosis.

Relevance. Currently, BVD is widespread in almost all countries of the world with intensive livestock farming. The special relevance of the problem lies in the large economic damage that consists of a decrease in milk yield during the disease, the death of young animals from serous pneumonia, the loss of live weight gain in young animals, the loss of productivity and reproduction of animals and, as a result, abortions and stillbirths, the birth of non-viable calves, as well as preventive, quarantine and liquidation measures. An important link in preventing the spread of viral diarrhea in cattle remains the rapid conduct of laboratory research. One of the most technologically advanced diagnostic methods is real-time polymerase chain reaction.

Methods. The diagnostic significance of the VetMAX BVDV Screening (Thermo Fisher) RT-PCR test system was assessed by sensitivity, specificity, and precision in conditions of repeatability and reproducibility. To determine repeatability, 5 samples of PT-80 cell culture infected with the reference strain "Oregon 24" and 7 samples of PT-80 cell culture infected with Ressa isolate were studied in tenfold dilutions from 10^-1 to 10^-7, by one operator in three parallel studies on the same equipment. To determine reproducibility and sensitivity, 5 samples of PT-80 cell culture infected with the reference strain "Oregon 24" and 7 samples of PT-80 cell culture infected with «Ressa» isolate were studied in ten-fold dilutions from 10^-1 to 10^-7 , by three operators on different days on the same equipment.

To determine the specificity, studies were conducted on 3 samples that did not contain the virus of viral diarrhea — bovine adenovirus type 1 strain Bovina — 10, rhinotracheitis virus of cattle strain "Orenburg" and parainfluenza virus 3 strain ZKSM.

Results. After mathematical processing of the results of PCR formulation for the assessment of reproducibility, the following results were obtained: the coefficient of variation (CV) for the VetMAX BVDV Screening (Thermo Fisher) test system was from 1.0–4.0 %; the Coefficient of variation (CV) for the assessment of repeatability was 1–3 %. The specificity of the test systems VetMAX BVDV Screening (Thermo Fisher) was 100%. The VetMAX BVDV Screening (Thermo Fisher) test system is sensitive to detecting the genome of the bovine viral diarrhea virus. So when setting up PCR samples of the Ressa isolate in the 10^-7 dilution, the CT values were determined at 38.18–39.24 cycles, and the reference VD virus "Oregon 24" in the 10^–5 dilution at 37.85–39.45 amplification cycles.

Relevance. The article presents data on the influence of unconventional feed additives of the Suntar zeolite on growth and development, physiological parameters, as well as meat productivity of fattening pigs in Yakutia.

Methods. For the experiments, 3 groups of animals were formed with 15 animals each. The rations of the experimental animals were identical, except for additional feeding of unconventional feed additives in the experimental groups.

Results. The use of Suntar zeolite in experimental groups of pigs allowed to improve the growth and development of animals by 3.02% and 6.68%, respectively. At the same time, in terms of average daily growth, the control group of pigs yielded to experimental groups of animals by 7.42% and 15.17%. During the experiments, a difference was found in the indices of the morphological composition of fattening young pigs. The control group of young animals by the number of red blood cells yielded to experimental groups of pigs by 2.00% and 4.00%. By the number of leukocytes, the control group of the group lost 1.02% and 1.16% to the experimental groups of animals. At the end of the experiment, a control slaughter of animals was carried out. Qualitative differences were established between the superiority of the experimental groups over the control group in terms of carcass weight by 5.25% and 1.98%, by internal fat yield by 0.71% and 0.64%, slaughter yield by 0.71% and 0.64 %, according to the meat content by 0.9% and 2.97%, as well as the share of fat 0.54% and 0.74%. Thus, the use of unconventional feed additives of the Suntar zeolite in the fattening of young pigs has shown effectiveness.

Relevance. According to the results of numerous scientific and laboratory studies, both lack of fatness and excessive obesity of livestock reduce the quality of meat and are the result of imperfect technology of growing and fattening animals or a low level of breeding and irrational use of feed.

Methods. Scientific and production experiments were carried out in the Tau Samal LTD Company LLP and the Plemzavod Almaty SEC Almaty region. The dynamics of live weight, fattening and slaughter qualities of young dairy and dairy and beef cattle during the periods of growing and fattening were studied.

Results. Gobies of experimental groups of different genotypes, which received feed additives in addition to the main diet, in terms of live weight, fattening qualities, growth and development rates, total and average daily gains, morphological and chemical compositions and energy value of meat favorably differed from uniform age counterparts from the control groups.

Relevance and methods. The article presents experimental data on the selection and genetic parameters of the productive qualities of young specialized meat breeds (Hereford and Kalmyk) in Yakutia.

Results. Musculature in animals of Hereford breed remained well developed, the animals remained well-fed. The skeleton is strong, in general, have strong and correctly set legs. The indices of elongation in bulls of Hereford breed were 114.5, the indices of incidence were 129.6, the index of chest was 56.6, and the index of pelvic was 87.1. In heifers of Hereford breed, the indices of elongation were 116.9, overgrowth 110.3, and bones 19.6. The dynamics of the live weight of young specialized meat breeds in the conditions of the farms of Central Yakutia shows that heifers and calves of the Kalmyk breed live birth weight was 19.2–20.8 kg, at 3 months of age 53.3–55.5 kg, at 5 months of age, 109.7–117 kg, respectively. In the period from birth to 3 months, the absolute increase was 34.1–34.7 kg with an average daily gain of 378–385 g.

Relevance. Merino sheep have horns, their uterus is hornless. In recent years, for practical reasons, many countries are breeding for hornless.

Methods. The article gives the results based on many years of observations and analysis on the phenomenon of hornless in the new meat breed “Etti Merino” created in southeastern Kazakhstan, the connection of hornless with productivity and the positive effect of selection on hornlessness on the breed.

Results. The use of hornless sheep-producers gave a positive result, live weight increased, slaughter indicators, and wool productivity improved.

Relevance and methods. During 2010–2017 in conditions of large pig-breeding complexes of Open Joint Stock Company Smolmyaso – Smolensk Region, limited liability company “Stupinsky Meat Processing Plant” and agricultural production cooperative Mashkino – Moscow Region a research and production experiment was conducted to determine the intravital productivity and slaughter indicators of young pigs of Russian, Canadian and French breeding. Experimental youngsters from 2 month age to a live weight of 100 kg were contained under conditions of control growing. The conditions of keeping, feeding and slaughter of young pigs were identical.

Results. When pigs reached a live weight of 95–105 kg they were evaluated on their own productivity and slaughter indicators.

Relevance. The basis for increasing livestock production is a solid food base. Therefore, it is important to increase production and improve the quality of all types of feed, primarily by expanding mixed crops, improving the technology of their cultivation and harvesting.

Methods. The aim of the research is the comparative productivity and nutritional value of annual forage crops for the production of haylage in Central Yakutia.

Results. Carry out the selection of promising annual crops for the production of haylage; establish the optimum time of sowing of annual crops and their mixtures on silage; study the features of growth, development and formation of yield and nutritional value of annual crops. According to the results of studies on the yield of green mass of forage crops were allocated in 1 sowing period two — component options-Vico-oat and pea – oat mixture (19.9–19.0 t/ha).

Relevance. The current paper has presented the study results of the effect of arid growing conditions on water deficit and foliage pigment (chlorophyll) of winter wheat varieties with various productivity.

Methods. The study was conducted in 2017–2019. The objects of study were the winter durum wheat varieties ‘Eyrena’, ‘Yubilyarka’, ‘Yakhont’, ‘Yantarina’, ‘Oniks’, ‘Lazurit’ developed in the FSBSI “Agricultural Research Center “Donskoy”. There have been used such methods in the current study as the testing of varieties on drought tolerance in conditions of simulated drought (“zasushnik”) proposed by V.V. Maimistov (1988); the method of identification of chlorophyll content in winter wheat leaves proposed by I.G. Shmatko (1976); the method of identification of residual water deficit proposed by L.S. Litvinov (1988).

Results. According to the study results there have been identified the most stable, productive winter wheat varieties ‘Yantarina’ and ‘Lazurit’, which possess mechanisms of adaptation to the water stress conditions. The varieties ‘Yantarina’ and ‘Lazurit’ also possess large productivity and chlorophyll content, as well as the smallest rise of residual water deficit in the increasing aridity with 169.7 and 159.5 g/m², 1.4 and 1.9 mg/100 g of raw weight, 24.6 and 25.7%, respectively.

Relevance. Processing of poultry farm waste makes it possible to obtain highly effective organic fertilizers that can replace mineral fertilizers, while significantly improving the environmental indicators of the region, the composition of the soil, crop fertility, and the quality of agricultural products.

Materials and results. The article discusses the advantages and disadvantages of using mineral and organic fertilizers. The negative impact of nitrogen, potash and phosphorus fertilizers on soil, hydrosphere and atmosphere pollution by various harmful elements is given. Their negative impact on agricultural products and public health is analyzed. At the same time, it is shown that the use of organic fertilizers improves the composition and properties of soils, increases crop yields, while growing environmentally friendly crops, which ensures food security of the country, improves people's health and increases their life expectancy. The use of organic fertilizers improves the composition and properties of soils, significantly increases the yield of agricultural crops, while growing environmentally friendly crops, which ensures food security of the country, improves people's health and increases their life expectancy. Organic fertilizers obtained from poultry farm waste significantly reduce the amount of emissions into the environment, increase environmental safety, and improve the quality of life of people living in the region.

Relevance and methods. The article considers the possibility of using the analysis of digital images for a comprehensive assessment of the physical characteristics of grain: vitreous and linear dimensions.

Results. A comparative characteristic of instrumental and organoleptic methods for determining these indicators by the following criteria is given: stability of results, speed of measurements and data processing. An algorithm has been developed that combines the ability to programmatically determine glassiness and linear dimensions of wheat grains based on their digital images. A relationship was found between an increase in the vitreous nature of the sample and an increase in the stability of the results.

Methods. A method of evaluating the influence of the duration of the winter period on the significance of regions from the beekeeping perspective is suggested. The method is an important addition to the development of digital approach in beekeeping based on the objective data: temperature, honey productivity of the crops, and other physical, chemical and biological factors.

Results. Using this method, the regions of the Russian Federation are ranked in the order of its significance for beekeeping.

Relevance and methods. The article addresses the issue of cleaning and disposal of an ever-increasing amount of waste from the milk processing industry. As a result of evaporation, air pollution occurs, and as a result of filtration into the soil — pollution of groundwater and nearby water bodies. Harmful gases emitted by sewage sludge exceed the maximum permissible concentrations, their smell is 4 — 5 points on the scale of organoleptic indicators. Gas generation is not controlled. They constantly enter the atmosphere. The most dangerous of them are sulfur and greenhouse (carbon dioxide, methane, nitrous oxide) gases. The composition of wastewater sludge is significantly affected by the quality of effluents discharged by the enterprise, which, as a rule, consist of: industrial, domestic and water from heat exchange and cooling systems.

Results. According to the analysis, the moisture content of bottom sediments was — 29.3–36.4%, inert substances became the main macrocomponents of sediments. They are also part of the mineral part of the soil. Based on the data of a model experiment, it was revealed that the second prototype showed the best results. So, in comparison with the control group in the second prototype, the content of organic matter decreased by 2.14%, while the reaction of the medium became more acidic, the difference was 1.3. There was also a decrease in the concentration of mobile forms of elements: phosphorus by 76.4 and potassium by 4.5 mg / kg, which in percentage terms was 26.6% and 0.6%, respectively. And the content of calcium and magnesium in sludge deposits increased by 14.2% and 10.5%, respectively.